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Hey guys, I'm back with another video! This time, we will cover the basics of cannabinoids. We'll discuss the history, biochemistry, pharmacology and total synthesis of these highly useful natural products. Recent research is used as an example of the importance and potential of cannabinoids in medicine. https://www.instagram.com/totalsynthesis_official/ https://www.patreon.com/totalsynthesis https://www.total-synthesis.com This video does not endorse the preparation of illegal substances. No detailed steps or procedures for syntheses of illegal drugs are discussed. I hope it's clear that here we focus on fascinating aspects of science and on the potential that compounds have in improving the lives of patients. 00:00 Introduction of medical cannabinoids; Applications of cannabidiol (CBD) and tetrahydrocannabinol (THC) for treatment of epilepsy and other conditions; Introduction of legal high of liverwort 04:35 History and Isolation of THC; Discovery of the endocannabinoid system, endocannabinoid receptors (CB1 and CB2) and endocannabinoids anandamide and arachidonylglyceride; CB1 antagonists as anti-obesity drugs; Total synthesis of THC and CBD by Raphael Mechoulam at the Weizmann Institute 15:18 Can you get legally high from moss or liverwort? Summary of pharmacological results from the key paper, based on work of Professor Gertsch and co-workers at the University of Bern; Tetrad test, Prostaglandins; Implications for medicinal applications 21:32 Organic synthesis and two total syntheses of cis-perrottetine by Professor Carreira at ETH Zürich (2018) and Professor Kim at Seoul University (2008); Discussion of key steps and synthetic strategies and reaction mechanisms 28:17 Closing remarks Mechoulam interview/documentary: - The Scientist (2015): https://www.youtube.com/watch?v=fu6FhJIyTEc Liverwort paper: - Uncovering the psychoactivity of a cannabinoid from liverworts associated with a legal high (Science Advances 2018, 4, 2166): http://advances.sciencemag.org/content/4/10/eaat2166 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of reactions and applications thereof with common conditions) - Nicolaou et al; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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Cookies is 3x more expensive but is there REALLY a difference between Cookies, and some cheap 'budget buds'? We are about to find out. IF YOU DIG THIS VIDEO 👍LIKE, 💬 COMMENT, 🔔 SUBSCRIBE https://goo.gl/brHuxL ______________________________________________________________ ⭐BECOME A MEMBER OF THE STRAIN GANG 👉👉https://www.patreon.com/StrainShow (get exclusive access to behind the scenes, bonus videos & live stream chat perks) 🔔GET THE STRAIN SHOW NEWSLETTER (get special offers and news) https://bit.ly/3w8ln5P 👕FRESH STRAIN SHOW MERCH https://strain-show-store.creator-spring.com/ 🙏THANK YOU FOR SUPPORTING THE CHANNEL AND HELPING ME SPREAD NUGGETS OF KNOWLEDGE! IT IS HIGH-LY APPRECIATED! ______________________________________________________________ STRAIN SHOW PODCAST 👉👉👉 https://apple.co/2ScF6PS ______________________________________________________________ 🔹Facebook : https://www.facebook.com/StrainShow/ 🔸Instagram: https://www.instagram.com/strainshow/ 🔹Twitter : https://twitter.com/StrainShow 🔸Email : [email protected] ______________________________________________________________ *** These videos are filmed legally in Denver, Colorado where Amendment 64 allows for medical and recreational cannabis use for adults. Any information presented on this channel is in an objective, informative, educational and non-glorified manner. This channel will never show or discuss the abuse, purchase, manufacture, sale or discovery of drugs or drug-related implements, and intends to fully comply with all youtube community guidelines. No sales / No links. Video Chapters 0:00 - Cookies is Super expensive 0:28 - How we are going to compare 1:08 - The Cookies Empire 1:49 - The price of Cookies 3:17 - The strains we are comparing 3:34 - What LOOKS better? 4:16 - What SMELLS better? 5:17 - A/B smell test 6:05 - What TASTE better? 7:09 - Effects comparison 7:44 - Microscope comparison 8:59 - Is it worth it? #StrainShow #Cookies #NuggetsOfKnowledge

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