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♦️Epidiolex contains 99% CBD and no other cannabinoids. ♦️OTC CBD oils : add adatives including other cannabinoids to enhance ♦️significantly reduced seizures in LGS, Dravet syndrome, or TSC who failed multiple previous antiseizure medicines in pts older than 1yr. ♦️ contraindicated in people sensitive to sesame oil seeds, pregnancy, suicidal, Hepato-toxic medication‘s ♦️ check LFTs; symptoms of liver problems during treatment with EPIDIOLEX: ♦️Talk to Dr. : Increase asleep, behavioral changes. anxiety, suicidal thoughts or self-harm, agitation, restlessness, aggression, irritability. ♦️ mostly fecal excretion, minimally in urine ♦️ Half life is 56 to 60 hours ♦️SE: increase in liver enzymes, sleepiness, decreased appetite, diarrhea, fever, vomiting, feeling very tired / weak, rash, sleep problems, infections. ♦️Oral solution: 100 mg/mL ♦️Start: 2.5 mg/kg/dose PO bid x1wk, Then prn 5 mg/kg/day qwk; titerate slowly. To max : 20 mg/kg/day; ♦️w/ or w/o food; ♦️taper dose gradually to D/C

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