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Today I received a box full of CBD products from Grass & Co and in this video I share my unboxing and the start of my CBD journey. CBD has become one of the biggest wellness products in recent years and I recently decided to try it for myself. If you too are interested in trying CBD but don't know where to start, then this video is perfect for you. Do subscribe to my channel and turn on notifications so you don't miss any of my progress videos. Live yourself young the Rae way 💜 Subscribe for more ♡ http://www.youtube.com/c/LiveYourselfYoung Let’s Connect... Instagram ♡ https://www.instagram.com/the_raeway/ Facebook ♡ hhttps://www.facebook.com/LIVEYOURSELFYOUNG/ Blog ♡ https://liveyourselfyoung.com/ Look & Feel Great With Health Supplements By Rejuvenated. https://rejuvenated.com/my/Liveyourselfyoung/ *Affiliate link. If you use my link to shop for your supplements or Youth plan book, I make a small commission and it doesn't cost you any more! USEFUL LINKS: Grass & Co https://grassandco.com/ HOW CAN CBD HELP YOU? https://lizearlewellbeing.com/healthy-living/health/can-cbd-help/ A beginner’s guide to CBD oil https://metro.co.uk/2020/01/31/beginners-guide-cbd-oil-12020552/

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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity

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After hearing him speak at CannMed2018 at UCLA and reading his incredible review article in Frontiers in Integrative Neuroscience, I knew we had to sit down and chat with Dr. Russo at The Emerald Cup about how #CannabisHelpsDementia. The quote of the interview: "It is the combination of THC, CBD and other components that presents the best promise for really making a meaningful difference in treating Alzheimer's Disease clinically." Ethan B. Russo, MD International Cannabis & Cannabinoids Institute You can read the article that inspired the quest here. https://www.frontiersin.org/articles/10.3389/fnint.2018.00051/full More than anything we need to get cannabis OFF the Controlled Substances Act Schedule I of Drugs so studies can be done, doctors and nurses can talk about it without fear of their licenses being revoked, and patients can have access to this ‘medicinal agricultural product’ that seems to be really great for the brain! The WHO agrees in RE-Scheduling internationally and Newsweek asked Dr. Russo for a comment: WHO RECOMMENDS RESCHEDULING CANNABIS IN INTERNATIONAL LAW FOR FIRST TIME IN HISTORY https://www.newsweek.com/who-recommends-rescheduling-cannabis-international-law-first-time-history-1324613 "Ethan Russo of the International Cannabis and Cannabinoids Institute told Newsweek that the WHO’s latest proposals were very significant given the organization's historical stance on cannabis. “These recommendations are of monumental importance as they may lead to the overcoming of barriers to research, enhance access of patients to cannabis-based medicine, and allow free commerce of cannabis products internationally,” he said." Thank you @AlexisBortell & @BryanTerry4TN for the excellent terminology on this healing plant and Dr. Ethan Russo for leading the way in cannabis and cannabinoid research. #KnowBrainer #CannabisHelpsDementia #AlzSucks #BeBold #EndAlz #CannabisCommunity #CannMed2018 #CannabisEducation Join Dave & Chela for Reefer Revolution LIVE! Sundays at 4:20 Pacific Blunt Commentary on the week's Cannabis News, Pot Politics & Marijuana Media. Covering the fastest growing business in California and the US - but can still get you locked up for life in some states. Maybe everywhere! #ReeferRevolution #Cannabis #CannabisCommunity YouTube: http://www.youtube.com/c/CannabisSavesTheWorld Facebook: https://www.facebook.com/ReeferRevShow/ Twitch: https://www.twitch.tv/ReeferRevolution Periscope: https://www.pscp.tv/DC420LA DLive: https://dlive.tv/ReeferRevolution WeedTV: https://watch.weedtv.com/store/channels/90 This is a medical and a recreational cannabis show originating from California designed to inform and educate people 18 and older about the benefits of the cannabis plant and to do our part to normalize the use of cannabis as a medicine and for recreation. Follow Reefer Revolution LIVE! Twitter: https://twitter.com/ReeferRevShow Facebook: https://www.facebook.com/ReeferRevShow Instagram: https://www.instagram.com/reeferrevshow DC on Twitter: https://twitter.com/DC420LA DC on Instagram: https://www.instagram.com/dc420la/ Coach Chela: https://twitter.com/AlzNotes https://www.instagram.com/alznotes/ https://www.facebook.com/AlzNotes/ We make no money on YouTube. YouTube finds my original content on cannabis "Not suitable for all advertisers" and DE-monetizes them despite allowing corporate media to profit on the topic. If you find our efforts worthy and want to see more, you can SUPPORT DC 420 here: BECOME A PATRON FOR AS LITTLE AS $1 A MONTH ON PATREON https://www.patreon.com/ReeferRevolution MAKE A CONTRIBUTE WITH PAYPAL OR A CREDIT CARD ON STREAMLABS: https://streamlabs.com/davecoennen Or with Bitcoin: https://greenaddress.it/pay/GA3XPNPWM2dvY6wiHJjXcWGUUD8Es9/ Cannabis products have intoxicating effects and may be habit forming; it can impair concentration, coordination and judgement. Do not operate a vehicle or machinery under the influence of this drug. There may be health risks associated with consumption of this product. For use only by Adults twenty-one (21) and older or medicinal patients with a recommendation over the age of eighteen (18). Keep out of the reach of children.