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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity

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When it comes to CBD products, consumers are always on the lookout for the next big thing. One product that has been generating a lot of buzz lately is BioLyfe CBD Gummies. These gummies claim to offer all the benefits of CBD in a delicious and convenient form. But with so many CBD products on the market, it can be hard to separate the hype from the truth. In this article, we will take a closer look at BioLyfe CBD Gummies to see if they live up to the hype.

The Taste Test: Are BioLyfe CBD Gummies as Delicious as They Claim?

One of the first things that consumers notice about BioLyfe CBD Gummies is the taste. These gummies come in a variety of flavors, including strawberry, orange, and lemon. Many users have reported that these gummies are surprisingly tasty and enjoyable to eat. The fruity flavors help mask the natural taste of CBD, making it easier for users to incorporate these gummies into their daily routine.

But taste is subjective, and not everyone may enjoy the flavor of these gummies. Some users have reported that the taste is too artificial or that the aftertaste is unpleasant. It ultimately comes down to personal preference, so it’s worth trying a sample pack to see if these gummies are right for you.

Overall, the taste test for BioLyfe CBD Gummies is a mixed bag. While many users find them delicious and enjoyable, others may not be as impressed. It’s essential to consider your taste preferences before investing in a large supply of these gummies.

The Effectiveness of BioLyfe CBD Gummies: Do They Deliver Results?

Aside from taste, the most crucial factor when it comes to CBD products is their effectiveness. BioLyfe CBD Gummies are marketed as a natural way to alleviate stress, anxiety, and pain. Many users have reported positive results after incorporating these gummies into their daily routine.

Some users have found that BioLyfe CBD Gummies help them relax and unwind after a long day. Others have reported relief from chronic pain and inflammation. These gummies are also said to help improve sleep quality and reduce anxiety levels. However, it’s essential to note that individual results may vary, and not everyone may experience the same benefits.

Overall, the effectiveness of BioLyfe CBD Gummies is promising. Many users have reported positive results, making these gummies a popular choice for those looking to incorporate CBD into their wellness routine.

The Ingredients: What Makes BioLyfe CBD Gummies Stand Out?

One of the key selling points of BioLyfe CBD Gummies is their all-natural ingredients. These gummies are made with organic hemp extract, which is known for its high-quality CBD content. The use of organic ingredients sets BioLyfe CBD Gummies apart from other CBD products on the market.

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In addition to organic hemp extract, these gummies also contain other natural ingredients, such as fruit juice and pectin. These ingredients are not only delicious but also provide additional health benefits. The absence of artificial flavors, colors, and preservatives makes BioLyfe CBD Gummies a healthier alternative to traditional gummy candies.

Overall, the ingredients in BioLyfe CBD Gummies are of high quality and can contribute to their effectiveness. By using natural ingredients, these gummies offer a safer and more holistic approach to wellness.

Potential Side Effects: What to Consider Before Trying BioLyfe CBD Gummies

While CBD is generally considered safe for most people, it’s essential to be aware of potential side effects before trying BioLyfe CBD Gummies. Some users may experience mild side effects, such as drowsiness, dry mouth, or changes in appetite. These side effects are usually temporary and can be managed by adjusting the dosage or frequency of use.

It’s also crucial to consult with a healthcare professional before incorporating CBD products into your routine, especially if you are pregnant, nursing, or taking medication. CBD can interact with certain medications, so it’s essential to seek professional advice to ensure your safety.

Overall, the potential side effects of BioLyfe CBD Gummies are minimal and manageable for most users. By being informed and cautious, you can enjoy the benefits of CBD without experiencing any adverse effects.

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Florence Comite, M.D. interviewing Dr. Eric Mitchell about CBD for Reversing Osteoperosis and Pain Management at the 24th Clinical Applications for Age Management Medicine CME Conference. Eric I. Mitchell, M.D., MA, FACPE, CPE President/CEO, TelMed Group, Bangor, ME Clinical Director, Pine Tree Alternative Pain Clinic, Bangor, ME Medical Director, AGRiMed Industries, LLC Medical Director, Hemp Commodity Industries, LLC Dr. Eric Mitchell is a practicing orthopedic surgeon and sports medicine doctor specializing in pain management. Upon completion of a premed program, he deferred the NBA for entry into medical school. Dr. Mitchell maintained a 30+year private practice in Orthopaedic Surgery and Sports Medicine, with a specialization in Arthroscopic Surgery. He was denoted ‘Outstanding Orthopaedic Resident’ by the Pennsylvania Orthopedic Society with his creation of the ‘E-M Angle of Blount’s Disease’. He also has a 10-year history as team physician for four US Olympic Teams covering two Olympics. He is also a certified physician executive. Dr. Mitchell was Senior Vice President of Medical Affairs for the inner city three-hospital network of North Philadelphia Health System. He initiated quality assurance programs of prevention, education and treatment (Q-PET) to provide a more equitable healthcare system for all citizens. He has traveled and lectured nationally and internationally. Dr. Mitchell's military career spanned 23 years and moved from Captain to the highest field grade officer position of Colonel in the United States Army Reserve and also served as a Deputy Inspector General at the Pentagon. The colonel (ret.) commanded two combat support hospitals. He was called to active-duty three times. Dr. Mitchell has been featured in numerous newspapers and magazines, including Ebony magazine, Physician Executive magazine, and the Philadelphia Daily News, is a published coauthor in major medical journals, and the author of "The Flow of Life: Keeping the Dream Alive." What is Age Management Medicine? A profound, meaningful, proven medical approach that’s setting the standard for 21st-century healthcare in all medical disciplines. It’s a progressive, preventative, proactive specialty focused on health, not disease. Age management medicine delivers measurable, life-changing patient outcomes—optimizing health and delaying or removing degenerative aging—using precision medicine, breakthrough technologies, evidence-based/customized modalities, and solid science. About AMMG CME-accredited Conferences. Physician Education. Age Management Medicine Certification. At the heart of AMMG is a passion—producing educational events that go well beyond the status quo. Balanced, diversified, inspirational, invigorating, interactive, challenging. For more information visit our website https://www.agemed.org

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