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Tune into the Heady Vermont facebook page each Monday at 8:45pm where we’ll start with an update and recap of the week in cannabis, then sit down for our featured interview. In this episode, recorded on Monday, February 19, 2018 , special guest Kathryn Blume of Heady Vermont joined us for a full recap of last weekend's Mary Janes: Women of Weed event as well as a preview of our first Heady Vermont #CBD Yoga, happening in Winooski on Sunday, March 4, 2018 starting at 4:00pm - more details tba

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#ASMR #Mukbang #GummyEyeballs Dive into a world of delightful sounds and mouthwatering treats with my latest ASMR Mukbang video! Join me as I indulge in giant gummy eyeballs, colorful candies, and refreshing drinks, all while capturing the satisfying crunch and squishy textures that make eating such a sensory experience. Perfect for ASMR lovers and food enthusiasts alike, this video promises to tickle your taste buds and soothe your mind. Don't forget to like, subscribe, and hit the bell for more delicious content!

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Nebraska Attorney General Mike Hilgers announced new enforcement efforts against Delta-8 THC retailers in Omaha during a Thursday morning press conference. For more Local News from KOLN: https://www.1011now.com/ For more YouTube Content: https://www.youtube.com/channel/UCsLNLP6umQ2n20sdjYfsvpA

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Scientists have shown that an active ingredient of cannabis significantly upregulates autophagy, extending both lifespan and healthspan in C. elegans nematode worms and demonstrating benefits to mouse neurons. Two of the most well-known components of marijuana are tetrahydrocannabinol, or THC, and cannabidiol, or CBD. They have the same atomic composition, but differ in structure. THC provides the high that is often associated with marijuana use. CBD, on the other hand, is considered benign and seems to possess antipsychotic, pro-cognitive, anti-inflammatory, anti-seizure, and antioxidant properties. In June 2018, the FDA approved Epidiolex, the first CBD-based prescription medication, for rare forms of epilepsy, and later for the treatment of some seizures. However, the research into both compounds is still in its infancy. In this new study, scientists dived deeper into the workings of CBD using C. elegans nematode worms, which is considered a good model for initial studies, including in geroscience. Previous research has shown that CBD can increase lifespan in C. elegans and zebrafish, but the mechanism had remained unknown. Another study found that CBD induces autophagy in cultured neuronal cells. In this new study, the researchers attempted to investigate the relationship between these two effects. Autophagy is the process of clearing away various cellular debris, such as misfolded proteins and dysfunctional organelles. Unsurprisingly, this maintenance system appears to be very important for health and longevity in numerous model organisms and in humans. The CBD treatment greatly increased autophagic activity in several tissues and cell types, most drastically by 78% in neurons. The researchers then validated those findings in vitro on several types of cells, including mouse primary hippocampal neurons. Importantly, impaired autophagy in the brain is considered a major cause of Alzheimer’s disease. Worms on CBD lived significantly longer than controls. The researchers also measured the worms’ healthspan. Many interventions that prolong lifespan in C. elegans often lead to functional impairment, such as decreased motility. Three popular health metrics in C. elegans that decline with age are pharyngeal pumping rate, reproductive capacity, and locomotion, and all three were significantly restored, rather than impaired, by CBD treatment. The gene SIRT1 has been a popular object of study in geroscience. One of its roles is a mediator of autophagy. By knocking out SIRT1 in mouse neurons, researchers were able to obliterate many of the benefits of CBD, pointing at a crucial role of SIRT1 in mediating CBD-induced effects. This study expands our understanding of CBD's effects, linking them to autophagy, an important process that keeps popping up on geroscientists' radars. It is encouraging that CBD demonstrates the strongest pro-autophagy effect in neurons, making it a potential anti-Alzheimer’s drug. Obviously, the fact that CBD increases autophagy in worms does not mean that using marijuana makes humans healthier, and we’ll need to see human trials on CBD and other compounds. SOURCES AND FURTHER READING ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Cannabidiol induces autophagy and improves neuronal health associated with SIRT1 mediated longevity - https://pubmed.ncbi.nlm.nih.gov/35445360/ Effect of Cannabidiol on the Long-Term Toxicity and Lifespan in the Preclinical Model Caenorhabditis elegans - https://pubmed.ncbi.nlm.nih.gov/33998871/ Developmental exposure to cannabidiol (CBD) alters longevity and health span of zebrafish (Danio rerio) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7205952/ Cannabidiol induces autophagy via ERK1/2 activation in neural cells - https://www.nature.com/articles/s41598-021-84879-2 EPIDIOLEX - https://youtu.be/zepKBzlKzdY FOOTAGE, IMAGES, AND MUSIC CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Stock footage & Images : Videoblocks.com, Shutterstock.com Music: "Elastic Vibe" by Ziv Moran PRODUCTION CREDITS ⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺⎺ Host, Producer, & Editor - Ryan O’Shea Writer - Arkadi Mazin Art - Mattijs Vonk, Tim Maupin Executive Producer - Keith Comito #CBD #Science #Longevity

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CBD Rich Cannabis Oil Extracted from Durga Matta II CBD Cannabis by Cold Acetone 12grams of oil extracted from 75grams of bud + 75 grams of stalk & trim (150g) Durga Mata II is a CBD rich strain of cannabis that has been bred specifically for medical users. Durga Mata II is the result of an ongoing project between Paradise Seeds and the CBD Crew to release more CBD rich strains onto the market. CBD is not a psychoactive compound but is known to be one of the leading medicinal components of marijuana. Plants with a roughly equal THC:CBD ratio can give the best medical relief to conditions such as inflammation, joint pain, spasticity, nausea and anxiety. Durga Matta II delivers a CBD content of 8.5% and THC of 7% from it's dried & cured flowers (extracts about 5X stronger) therefore this strain of cannabis is better suited for medicinal users. Durga Mata II CBD by Paradise Seeds https://www.paradise-seeds.com/en/durga-mata-ii-cbd