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Semaglutide is an exciting new drug that has been gaining attention for its potential to aid in weight loss. Approved by the FDA for weight management in adults with obesity or overweight, semaglutide works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1). This hormone helps regulate blood sugar levels, but it also plays a role in appetite control and weight management. Understanding how semaglutide works can help us appreciate its potential benefits for those struggling with weight issues.

Signaling Pathways Activation

One of the key mechanisms of action of semaglutide is the activation of certain signaling pathways in the body. When semaglutide binds to GLP-1 receptors in the brain, it triggers a cascade of events that result in reduced appetite and increased feelings of fullness. This can lead to reduced food intake and ultimately, weight loss. By targeting specific pathways related to appetite regulation, semaglutide offers a targeted approach to weight management.

Slowing Gastric Emptying

Another way semaglutide helps with weight loss is by slowing down the rate at which food moves through the stomach. This delay in gastric emptying can help control blood sugar levels and reduce spikes in insulin, which are common in people with obesity or diabetes. By slowing gastric emptying, semaglutide can help regulate appetite and food intake, leading to gradual weight loss over time.

Impact on Energy Expenditure

Semaglutide has also been shown to have an impact on energy expenditure, or the number of calories the body burns at rest. Studies have suggested that semaglutide may increase energy expenditure, helping individuals burn more calories even when they are not active. This can further contribute to weight loss by creating a calorie deficit, where the body burns more calories than it consumes.

Improvement in Insulin Sensitivity

Insulin sensitivity plays a crucial role in weight management and overall metabolic health. Semaglutide has been found to improve insulin sensitivity in individuals with obesity or diabetes, leading to better blood sugar control and reduced risk of weight gain. By enhancing insulin sensitivity, semaglutide can help the body utilize glucose more effectively and prevent excess fat storage, ultimately supporting weight loss goals.

Long-Term Effects on Weight Maintenance

Research has shown that semaglutide can have long-term effects on weight maintenance, even after the drug is discontinued. This sustained weight loss may be due to the lasting changes in appetite regulation, energy expenditure, and metabolic function that semaglutide helps facilitate. By addressing multiple aspects of weight management, semaglutide offers a comprehensive approach to achieving and maintaining a healthy weight in the long run.

In conclusion, the mechanism of action of semaglutide for weight loss involves targeting specific pathways related to appetite regulation, gastric emptying, energy expenditure, and insulin sensitivity. By understanding how semaglutide works at a molecular level, we can appreciate its potential to help individuals struggling with weight issues achieve their goals in a safe and effective manner.

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The Next Gen Pharmacy Conference, ATRIUMX February 27 – March 1, 2025 The conference that puts you in control— you create the content. Thank you Independent Pharmacy Cooperative (IPC) for sponsoring this episode of TWIRx! Check out the iCare+ digital health platform: https://myicareplus.com/ 2-Part Special: FIRST -- Special guests: Atrium24 founder, Dr. Nicolette Mathey PharmD, ATRIUMX organizers Kelley Babcock, and Jen Diehl, and Pharmacy Busienss Consultant and owner Donnie Jordan Vice President Pharmacy Strategy at Health Growth Pharmacy Solutions. NEXT -- on the second half of TWIRx, we talk with Dr. Julie Schulz, MD, MPH and Dr. Michael Dovidio, PharmD from Avalon Health talk about the challenges of 'quick fix' treatments and weight management plans with the inclusion of GLP-1s. From the article titled: "How to Maximize the Value of GLP-1 Drugs While Improving Health Equity" --Julie and Mike talk about the real world needs of people who want to lose weight, doing it the right way for long term benefit. Due to the continued high cost, only patients with greater financial resources or those with generous employer-sponsored drug benefits will be able to afford the medications for obesity. This can exacerbate health inequities, likely driving significantly higher costs for public and commercial health plans, intensified by the new financial strain from weight loss medications. Rather than denying coverage for GLP-1s for obesity, health plans could modify eligibility policies to require data from a standardized set of laboratory tests and other biometrics to identify patients in most need of GLP-1s and verify medical necessity. This approach would reduce inappropriate prescribing while ensuring that patients who are most likely to benefit from the drugs have access to them. ATRIUMX Pharmacy Conference and the Truth about GLP-1 Drugs | TWIRx