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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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When it comes to the ketogenic diet, finding delicious snacks that fit within the guidelines can be a challenge. That’s where Kiss My Keto’s Keto Gummies come in. These gummies are marketed as a keto-friendly snack that satisfies your sweet cravings without kicking you out of ketosis. But are they really as good as they sound? In this article, we’ll take a closer look at Kiss My Keto Keto Gummies to see if they live up to the hype.

What are Kiss My Keto Keto Gummies?

Kiss My Keto Keto Gummies are a convenient and tasty snack option for those following a ketogenic diet. Each gummy is packed with collagen protein and MCT oil to help support your keto lifestyle. These gummies are sweetened with stevia and erythritol, making them a guilt-free treat that won’t spike your blood sugar levels. With flavors like raspberry and lemon, these gummies are sure to satisfy your sweet tooth.

One of the main selling points of Kiss My Keto Keto Gummies is their convenience. These gummies are individually wrapped, making them easy to grab on the go. Whether you’re heading to work or hitting the gym, these gummies are the perfect snack to have on hand. Plus, with only 3g of net carbs per serving, you can enjoy these gummies without worrying about sabotaging your ketosis.

Do Kiss My Keto Keto Gummies Taste Good?

When it comes to keto snacks, taste is key. Fortunately, Kiss My Keto Keto Gummies deliver on flavor. The raspberry and lemon flavors are bright and refreshing, making them a tasty treat any time of day. The texture of these gummies is soft and chewy, just like traditional gummies. Whether you’re a fan of fruity candies or just looking for a quick snack, Kiss My Keto Keto Gummies are sure to satisfy your cravings.

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Many people find that following a ketogenic diet can be challenging when it comes to finding satisfying snacks. Kiss My Keto Keto Gummies offer a delicious solution that won’t derail your progress. With their tasty flavors and convenient packaging, these gummies are a must-have for anyone following a keto lifestyle.

Are Kiss My Keto Keto Gummies Worth the Price?

While Kiss My Keto Keto Gummies are tasty and convenient, some may be hesitant to try them due to their price. These gummies can be more expensive than traditional gummy candies, but the quality ingredients and keto-friendly formula make them worth the investment. For those looking for a guilt-free snack that fits within their keto diet, Kiss My Keto Keto Gummies are a great option.

Overall, Kiss My Keto Keto Gummies are a delicious and convenient snack option for anyone following a ketogenic diet. With their tasty flavors, quality ingredients, and low net carb count, these gummies are sure to become a staple in your keto pantry. Give them a try and see for yourself why Kiss My Keto Keto Gummies are as good as they sound.

Conclusion

In conclusion, Kiss My Keto Keto Gummies are a delicious and convenient snack option for anyone following a ketogenic diet. With their tasty flavors, quality ingredients, and low net carb count, these gummies are sure to satisfy your sweet cravings without derailing your progress. If you’re looking for a guilt-free treat that fits within your keto lifestyle, give Kiss My Keto Keto Gummies a try.

Remember, it’s essential to listen to your body and find snacks that work for you. While Kiss My Keto Keto Gummies may be a great option for some, others may prefer different snacks or flavors. Experiment with different options and find what works best for your taste buds and your keto goals. Happy snacking!

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Weight loss is a common goal for many people, but finding the right products and programs to help achieve that goal can be overwhelming. Shark Tank, the popular TV show where entrepreneurs pitch their business ideas to a panel of investors, has seen its fair share of weight loss products over the years. Some of these products have gone on to become huge successes, while others have flopped. In this article, we will take a comprehensive look at some of the weight loss wins on Shark Tank, exploring the innovative products and strategies that have helped people shed pounds and improve their health.

The Skinny Mirror: A Reflection of Success

One weight loss product that made a splash on Shark Tank is The Skinny Mirror. This innovative mirror is designed to make users appear slimmer than they actually are, providing a boost of confidence and motivation to stick to their weight loss goals. The creators of The Skinny Mirror pitched their product on the show and garnered interest from several of the investors. Since appearing on Shark Tank, The Skinny Mirror has seen a surge in sales and positive reviews, with many customers crediting it with helping them stay on track with their weight loss journey.

One of the reasons why The Skinny Mirror has been so successful is its focus on the psychological aspects of weight loss. By providing users with a positive self-image, the mirror serves as a powerful tool for boosting confidence and self-esteem. This can be especially helpful for individuals who have struggled with their weight in the past and may have low self-confidence as a result. The Skinny Mirror shows that sometimes a simple change in perspective can make a big difference when it comes to weight loss success.

In addition to its psychological benefits, The Skinny Mirror also offers practical advantages for users. By seeing a slimmer version of themselves in the mirror, individuals are motivated to continue making healthy choices and working towards their weight loss goals. This visual feedback can be a powerful motivator, helping users stay committed to their health and wellness journey. The Skinny Mirror is a shining example of how a small change in daily habits, like looking in a different mirror, can lead to big results in the long run.

MealEnders: The Sweet Solution to Overeating

Another weight loss success story from Shark Tank is MealEnders, a unique product designed to help individuals curb overeating and make healthier food choices. MealEnders are lozenges that combine sweet flavors with a cooling sensation, providing a sensory cue that signals the brain that the meal is over. By engaging both the taste buds and the trigeminal nerve, MealEnders help users avoid the temptation to overeat and stay on track with their weight loss goals.

The creators of MealEnders appeared on Shark Tank to pitch their product and received a positive response from the investors. Since then, MealEnders has gained a loyal following of customers who swear by its ability to prevent mindless snacking and reduce cravings for unhealthy foods. With flavors like Chocolate Mint and Cinnamon, MealEnders offer a tasty and convenient way to curb overeating and break the cycle of emotional eating.

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One of the reasons why MealEnders has been so successful is its focus on the science of satiety. By providing a sensory cue that the meal is over, MealEnders help users feel satisfied and content after eating, reducing the urge to reach for seconds or snacks. This can be especially helpful for individuals who struggle with portion control or emotional eating, as MealEnders provide a simple and effective way to stay in control of their eating habits. MealEnders is a sweet solution to overeating that has helped many people achieve their weight loss goals.

PlateJoy: Personalized Nutrition for Weight Loss

PlateJoy is a meal planning service that provides personalized nutrition plans to help individuals achieve their weight loss goals. By taking into account dietary preferences, health goals, and lifestyle factors, PlateJoy creates customized meal plans and grocery lists to make healthy eating easy and convenient. The creators of PlateJoy pitched their service on Shark Tank and attracted the interest of the investors, who saw the potential for a personalized nutrition solution in the weight loss market.

Since appearing on Shark Tank, PlateJoy has become a go-to resource for individuals looking to lose weight and improve their health through personalized nutrition. With features like recipe customization, online grocery shopping, and virtual coaching, PlateJoy offers a comprehensive approach to healthy eating that is tailored to each user’s unique needs. By taking the guesswork out of meal planning and providing ongoing support, PlateJoy helps users stay motivated and committed to their weight loss journey.

One of the key benefits of PlateJoy is its focus on sustainability and long-term success. By creating personalized meal plans that fit into each user’s lifestyle, PlateJoy helps individuals develop healthy eating habits that they can maintain for the long haul. This approach sets PlateJoy apart from other meal planning services and fad diets, as it prioritizes sustainable changes that promote lasting weight loss results. PlateJoy is a proven solution for individuals looking to lose weight and improve their health through personalized nutrition.

Bala Bangles: Stylish Strength Training for Weight Loss

Bala Bangles are wearable weights that add resistance to workouts and everyday activities, helping users burn more calories and build strength. These stylish bracelets are designed to fit comfortably on the wrists or ankles, making them a perfect accessory for any workout or daily routine. The creators of Bala Bangles appeared on Shark Tank to pitch their product and garnered interest from the investors, who saw the potential for a fashionable and functional fitness accessory.

Since debuting on Shark Tank, Bala Bangles have become a must-have item for fitness enthusiasts looking to amp up their workouts and slim down. With options for different weights and colors, Bala Bangles offer a customizable and convenient way to add resistance training to any exercise routine. By wearing Bala Bangles during activities like yoga, Pilates, or walking, users can increase the intensity of their workouts and burn more calories, leading to faster weight loss and toning results.

One of the key benefits of Bala Bangles is their versatility and ease of use. Unlike traditional dumbbells or weight machines, Bala Bangles are compact, portable, and stylish, making them perfect for on-the-go workouts or at-home exercises. Whether worn during a workout class or while running errands, Bala Bangles provide a subtle but effective way to incorporate strength training into daily life. Bala Bangles are a stylish and functional solution for individuals looking to enhance their workouts and achieve their weight loss goals.

FitBod: Personalized Fitness for Weight Loss Success

FitBod is a fitness app that provides personalized workout plans based on each user’s fitness level, goals, and preferences. By using advanced algorithms and artificial intelligence, FitBod creates customized strength training and cardio routines to help individuals reach their weight loss goals and build muscle. The creators of FitBod presented their app on Shark Tank and received positive feedback from the investors, who recognized the potential for a personalized fitness solution in the weight loss market.

Since its appearance on Shark Tank, FitBod has become a top-rated fitness app for individuals looking to lose weight, build muscle, and improve their overall health. With features like workout tracking, progress monitoring, and exercise recommendations, FitBod offers a comprehensive approach to fitness that adapts to each user’s changing needs and abilities. By taking the guesswork out of workout planning and providing expert guidance, FitBod helps users stay motivated and committed to their weight loss journey.

One of the advantages of FitBod is its adaptability and scalability. Whether users are beginners or seasoned athletes, FitBod can create personalized workout plans that challenge and support them at every stage of their fitness journey. By incorporating data-driven insights and user feedback, FitBod continuously refines and improves its algorithms to provide the most effective and efficient workouts for each individual. FitBod is a powerful tool for individuals looking to achieve their weight loss goals and stay in shape for life.

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Looking for a natural way to combat cravings and lose weight—without GLP-1 injections? Sarah Kennedy, founder and CEO of Calocurb, shares how she and a group of scientists brought their revolutionary product to market, and how it’s taking the world by storm. Sarah recognized Calocurb as a strategic tool to support healthier choices and built the company around that principle. A life-long struggle with weight and love-hate relationship with food made this a passion project. When the product delivered for her where nothing else had, making sure others had access to it became her mission. She takes inside the science that makes Calocurb uniquely effective. Inspired by ancient practices—from Scots chewing bitter berries during famines and Kalahari tribesmen chewing bitter roots before hunts—scientists theorized that bitter compounds might suppress appetite today. And they were right. A variety of hops grown in New Zealand triggers the greatest response. After years of testing and clinical trials with both men and women, Calocurb has been proven to reduce hunger, food cravings and calorie intake to help people lose weight without the adverse side effects of Ozempic or other GLP-1 injectables. Sarah lays out why this product differs from synthetic injectables, and how practitioners are using it in conjunction with injectables, as a natural way to titrate off them, and as an alternative to them. People are also using Calocurb selectively in a variety of ways. Acknowledging that appetite and weight loss have nothing to do with willpower, and that women are more responsive to GLP-1 than men, Sarah shares how women are using Calocurb during their monthly cycles with great success. This isn’t another dodgy supplement. Tune in to get this game-changing information. COUPON CODE: Use code TM10 to get 10% OFF for a limited time. TESS’S TAKEAWAYS: An alternative to GLP-1 injectables, Calocurb is a natural appetite suppressant. Calocurb contains three ingredients only: All natural and plant-based. Unlike synthetic injectables, Calocurb stimulates natural GLP-1 production. Calocurb is used to titrate off GLP-1 injectables to maintain results. This supplement can be used selectively to curb food cravings and calorie intake. Ingested rather than injected, Calocurb doesn't interfere with the liver and kidneys. Calocurb can be taken with other medications. By reinstating hunger and satiety cues, Calocurb supports the gut-brain connection. SARAH KENNEDY BIO Founder and CEO of Calocurb, Sarah Kennedy shepherded years of scientific research and clinical trials to bring a revolutionary product to market. A veterinarian by training, with more than 20 years’ experience in dietary and animal nutrition, Sarah has held a number of CEO and senior executive positions in food and agriculture industries, at companies including Fonterra and Healtheries/Vitaco NZ. In 2010, at Massachusetts Institute of Technology, Sarah completed a Sloan Fellowship Program in Global Leadership and Innovation. She has held a number of board positions with government, private, and philanthropic organizations. CONNECT WITH CALOCURB Website: https://www.calocurb.com/ Facebook: https://www.facebook.com/calocurbGLOBAL/ Instagram: https://www.instagram.com/calocurb LinkedIn: https://www.linkedin.com/company/calocurb/ Meet Tess Masters: Tess Masters is an actor, presenter, health coach, cook, and author of The Blender Girl, The Blender Girl Smoothies, and The Perfect Blend, published by Penguin Random House. She is also the creator of The Decadent Detox® and Skinny60® health programs. Connect With Tess: Website: https://tessmasters.com/ Podcast Website: https://ithastobeme.com/  Facebook: https://www.facebook.com/theblendergirl/ Instagram: https://www.instagram.com/theblendergirl/ Twitter: https://twitter.com/theblendergirl YouTube: https://www.youtube.com/user/theblendergirl LinkedIn: https://www.linkedin.com/in/tessmasters/ Get Healthy With Tess Skinny60®: https://www.skinny60.com/ Join the 60-Day Reset: https://www.skinny60.com/60-day-reset/ The Decadent Detox®: https://www.thedecadentdetox.com/ Join the 14-Day Cleanse: https://www.thedecadentdetox.com/14-day-guided-cleanses/ The Blender Girl: https://www.theblendergirl.com/ Thanks for listening! If you enjoyed this conversation and think others would benefit from listening, share this episode. And, please post your comments or questions below. I’d love to hear what you think. Subscribe to the podcast. Get automatic updates so you never miss an episode. Subscribe to this show on Apple Podcasts, Stitcher, or your favorite podcast app. Leave a review on Apple podcasts. Ratings and reviews from listeners help our podcast rank higher so it can reach more people. Please leave a review on Apple Podcasts.

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