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📢 Dr. Bikman’s Community & Coaching Site, Insulin IQ: https://insuliniq.com and/or 📢 Become an Insider, Ben’s website: https://www.benbikman.com In this Metabolic Classroom lecture, Ben challenges the conventional insulin-centric model of type 1 diabetes by introducing the “bi-hormonal hypothesis” proposed by Dr. Roger Unger. While insulin deficiency is a defining feature of T1DM, Dr. Bikman emphasizes the overlooked role of glucagon in driving hyperglycemia, ketone production, and muscle wasting. In normal physiology, insulin from beta cells locally suppresses glucagon from alpha cells. But in type 1 diabetes, this local regulation is lost, allowing glucagon to run unchecked—even when blood glucose is high. Ben explains how injected insulin, although lifesaving, can’t mimic the precise intra-islet insulin levels needed to suppress glucagon secretion. This mismatch helps explain why blood sugar control can remain elusive despite appropriate insulin use. Excess glucagon ramps up liver glucose output and ketogenesis, creating a more complex hormonal storm than insulin alone can calm. The lecture also explores new therapeutic strategies—including glucagon receptor blockers and GLP-1 agonists—that may help suppress glucagon more effectively. Dr. Bikman urges a shift in perspective: instead of seeing diabetes as just a disease of insulin, it’s time to recognize its bi-hormonal nature and tailor treatment accordingly. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, ad-free podcast episodes, show notes and references, online Office Hours access, Ben’s Research Review Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. #Type1Diabetes, #T1DM, #InsulinResistance, #Glucagon, #RogerUnger, #DiabetesScience, #MetabolicHealth, #BloodSugar, #Ketones, #DiabetesEducation, #InsulinTherapy, #Endocrinology, #DiabeticKetoacidosis, #DiabetesTreatment, #DiabetesResearch, #MetabolicDisorders, #GlucoseControl, #BetaCells, #AlphaCells, #PancreaticHealth #keto #metabolicclassroom #benbikman #drbenbikman Timestamps (approximate): 00:01 – Rethinking the Insulin-Centric Model 01:04 – Dr. Roger Unger and the Bi-Hormonal Hypothesis 03:15 – Glucagon: The Forgotten Hormone 05:17 – Glucagon Physiology and Liver Function 08:23 – Pericrine Regulation in Pancreatic Islets 10:36 – What Goes Wrong in Type 1 Diabetes 12:45 – Glucagon Secretion Without Insulin 13:50 – Glucagon’s Role in Ketogenesis and Protein Breakdown 15:54 – The Limits of Injected Insulin 17:58 – Why Systemic Insulin Misses the Mark 19:10 – Explaining Glucose Variability and High Insulin Needs 21:34 – Clinical Implications of Hyperglucagonemia 23:32 – Muscle Wasting and Amino Acid Shuttling 24:29 – Blocking Glucagon: A Therapeutic Strategy 25:29 – Type 2 Diabetes and Glucagon Resistance 26:21 – Drug Therapies Targeting Glucagon 28:31 – GLP-1 Drugs as Glucagon Suppressors 29:37 – Final Thoughts: A Paradigm Shift in Diabetes Treatment Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd

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Join Inshapefam on Youtube: https://www.youtube.com/channel/UC3imX_9eaMl6-NuokFyHH0w/join ______ D I S C L A I M E R “How long does it take to see results?” Just because one member sees results in 10 to 30 days doesn't mean you will experience the same outcome. This is because your body is different and unique (whether you have a smaller build or your starting size is bigger). There are many factors at play: how often you work out, the types of workouts, body type, weight, genetics, age, food choices, meal portions, daily habits, lifestyle, environment, whether you're in a calorie deficit or surplus, etc. This means that how quickly you see results does not solely depend on my workouts; it's a team effort between YOU and me. Beginners (those new to exercise or who rarely exercise) and members with an average level of fitness often see results faster because their bodies adapt more easily to new changes. If you're not a beginner (even if you've taken a long break), your body may need more time to adjust from old routines to new ones. Due to the differences among us (fitness goals, body size, shape, age, health, and physical conditions…), my workouts should not be relied upon as a substitute for, nor do they replace, professional medical advice, diagnosis, or treatment. Start at your level, stay consistent with the programs or weekly plans on my website, build healthy eating habits, limit unhealthy foods, and surround yourself with motivation. You will see results like many Inshape members have. Remember to take your "Before and After" photos, share your progress to inspire us! ♡ _____ Guys don’t forget: You cannot choose where you want to lose fat on your body, but you can decide where to focus and which part of your body to target and train more. You will eventually lose fat all around, and adding the RIGHT exercises will help you reach your goals faster. To really see fat loss results, you need to be in a slight calorie deficit and well-balanced diet, incorporate cardio, add weight training to strengthen your muscles and tighten loose skin. Cheers! ______ #hiitworkout #hiitforbeginners #fatlossfast

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Lizzo, the Grammy-winning artist known for 'Truth Hurts,' shares her weight loss journey, including her experience with Ozempic and GLP-1 drugs. She discusses why she chose to focus on dietary changes, particularly incorporating meat, to achieve her goals. Lizzo emphasizes the importance of finding what works for you and encourages understanding for those using medication to manage weight. This video explores her transformation and offers insights into her approach to health and wellness.

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How to Measure Body Fat Percentage for Overweight Children. Part of the series: How to Treat Various Child Ailments. The best way to the measure body fat percentage for an overweight child is to use a tool called the Body Mass Index. Learn how this tool is used to measure body fat with guidance from a doctor in this free video on child health treatments. Read more: http://www.ehow.com/video_5574567_measure-fat-percentage-overweight-children.html

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Former FDA Commissioner Dr. David Kessler drops truth bombs about GLP-1 drugs that 4% of Americans are taking! He reveals the shocking reality: people are micro-dosing these powerful medications to lose those last few pounds, but 20% go back on after stopping. The real problem? There's no nutritional therapy around these prescriptions, and when you go off, the weight comes back because the food addiction circuits in your brain are still there. Ready to create compelling health content that cuts through the noise? DM us to collaborate on video marketing that educates and engages your audience! 📱✨ #GLP1 #Ozempic #WeightLoss #FoodAddiction #HealthContent #VideoMarketing #ContentCreation #HealthEducation #FDA #DrDavidKessler #WeightLossJourney #HealthyLifestyle #MedicalContent #WellnessInfluencer #HealthInfluencer

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Curious about the keto diet? Find out how it can transform your energy, help with weight loss, and boost mental clarity. Is it the secret to a healthier you? For more tips, recipes, and honest insights, subscribe to Confessions of A Nutrition Freak! 🥑🔥

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Want to know the keto diet secrets? 🥑 This quick video reveals how keto helps you lose weight, boost energy, and improve health. Learn the basics, debunk myths, and start your journey to a healthier lifestyle today! Watch the full video here: https://www.youtube.com/watch?v=cUb4UKBL_aQ #KetoDiet #burnfat #HealthTips #weightloss #Ketosis #HealthyEating #Nutrition #DietTips #BoostEnergy #KetoForBeginners #HealthyLifestyle #Health #shorts #viralvideo #foryou

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