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Incidence of Obesity & Type 2 diabetes is increasing more than ever! The current set of interventions are restricted to tracking blood sugar level using CGM, fad diets, high protein diets & pharmaceutical drugs.No wonder the therapeutic success is dismal! Now India is experiencing another wave of synthetic compound approach- GLP-1 receptor Agonists with a hope to control glycemic control, trigger weight loss & improve cardiovascular health. While at macro level this synthetic compound looks like a effective solution, if we dug deeper it may be starting point of metabolic disaster What exactly is GLP-1? GLP-1 is an incretin hormone naturally produced inside our body. Our gut microbiome could synthesise fibre, polyphenols & even N-oleoyl serinol in olive oil into GLP-1. This incretin hormone promotes satiety regulation, blood sugar control & even regulates heart health If the body is not able to produce GLP-1, then it is a biochemistry problem & the body is not at ease. Since there has been no tech that could measure GLP-1 levels( we the only company in India that can measure & quantify this incretin hormone), it is assumed that people suffering from obesity or type 2 diabetes suffer from GLP-1 deficiency. However no one actually measures specific inflammatory factors causing obesity. Is it really a GLP-1 deficiency? Or high P-cresol production? Low Butyrate Production? Elevated TMAO or high LPS? Until you know the source code for obesity how can you even prescribe interventions to address the disease. GLP-1 receptor Agonists may work for some people who actually have GLP-1 deficiency. However, the effectiveness of this drug depends upon: 1.Functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs 2.Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help 3.GLP-1 drugs also activates endothelial nitric oxide synthase which could potentiate nitric oxide signalling that could dilate blood vessels, regulate glucose uptake & have anti-obesity impact. However for this to function, this enzyme should be coupled with endothelial cells. If it is uncoupled due to systemic inflammation or oxidative stress, it cannot trigger production of nitric oxide & these GLP-1 drugs will not work 4. These drugs act as an artificial break on your satiety paddle & slow down movement along your digestive tract & would cause constipation, bloating & other digestive troubles. 5. Even for people this drug works, they need to take this continuously as withdrawal from these drugs would lead to weight gain Citations https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC8793908/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8833664/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 #glp1medication #glpromaxindonesia #glp1forweightloss #glp1weightloss #glpromax #weightloss #obesityepidemic #obesity #obesitymedicine #obesityprevention #obesitycontrol #obesityawareness

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How does fat get burned? Watch this video to find out. Timestamps 0:00 How fat gets burned 1:17 What triggers fat burning? 3:14 Insulin resistance and fat burning 3:57 Low-calorie diets don’t induce fat burning 5:06 Key takeaways In this video, we’re going to talk about how fat gets burned in your body. When you think about fat burning, you may picture a fire or heat burning or melting away fat—it doesn’t quite work like that. Fat is actually released from fat cells and then used for energy. Your fat cells are primarily storing triglycerides. These are fats in a liquid state. An enzyme called hormone-sensitive lipase then helps release and break down these fats so they can be used for energy. Lipase is triggered by certain hormones. There are several ways to trigger lipase: 1. Absent insulin (insulin inhibits lipase) 2. Fasting 3. Adrenaline 4. Growth hormone 5. Thyroid hormone When insulin is not available, you stop storing fat and start burning it. The absence of insulin is the ultimate trigger for lipase. Insulin resistance sends signals to the pancreas, which makes it pump out 5-7 times more insulin. Keep in mind that insulin resistance is a situation of too much insulin—not too little. A low-calorie diet does not trigger lipase. Why? Because if you still have carbs, then you’re still triggering insulin, which blocks lipase. However, a healthy ketogenic diet does kickstart the fat-burning process by lowering insulin production. This allows your cells to become sensitive to insulin again. Dr. Eric Berg DC Bio: Dr. Berg, age 57, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. Follow Me On Social Media: Facebook: https://bit.ly/FB-DrBerg Instagram: https://bit.ly/IG-DrBerg TikTok: https://bit.ly/TikTok-DrBerg ABOUT DR. BERG: https://www.drberg.com/dr-eric-berg/bio Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients so he can focus on educating people as a full time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Thanks for watching. I hope this video helped clear up how fat gets burned. See you in the next video.