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Revolutionizing Weight Loss: Eli Lilly's Promising Oral Pill, Orforglipron In this episode, Laraine and Christopher Durham discuss the breakthrough results of Eli Lilly's Orforglipron, a once-daily oral GLP-1 weight loss medication. The phase three trial results show comparable weight loss and diabetes control to injectable counterparts like Ozempic and Wegovy but with greater convenience and accessibility. This promising treatment does not require special timing or dietary restrictions, distinguishing it from other existing oral GLP-1s. Eli Lilly's success is heightened by the absence of liver toxicity, manageable side effects, and significant interest from both the medical community and investors. The episode also touches on competition in the oral GLP-1 market, including Novo Nordisk's advancements and the potential for new treatments that may reshape obesity management and healthcare practices. The hosts discuss the impact this could have on reducing long-term reliance on expensive injectables, emphasizing the potential for broader access and cost-effectiveness in weight management. TIME ARTICLE: https://time.com/7278429/weight-loss-obesity-pill-eli-lilly/ DOWNSIZED WEBSITE: https://thedownsized.org/ DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store JOIN CLUB DOWNSIZED: @thedownsized FOR SPONSORSHIPS, BRAND DEALS & COLLABS: https://thedownsized.org/contact/ 00:00 Introduction to Orforglipron: A New Weight Loss Pill 01:10 Phase Three Trial Results 02:16 Comparison with Other GLP-1 Treatments 03:36 Market Implications and Investor Reactions 05:06 Future of Oral GLP-1s and Competing Drugs 06:22 Impact on Patients and Healthcare 07:50 Discussion and Final Thoughts

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