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In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Jens Juul Holst, a renowned Danish physician and physiologist, to discuss GLP-1, a hormone transforming our understanding of metabolic health. Dr. Holst, who discovered and described GLP-1, explains its role as a gut-derived hormone that regulates appetite, insulin secretion, and digestion, offering a groundbreaking approach to managing obesity and type 2 diabetes. The conversation explores how GLP-1 receptor agonists, have evolved into powerful medications. These drugs help patients achieve significant weight loss, reverse diabetes, improve cardiovascular health, reduce inflammation, and potentially enhance cognitive function. Dr. Holst delves into their long-term implications for preventing diabetes, extending health spans, and even reducing the risks of obesity-related cancers and improving fertility. Dr. Holst emphasizes that while GLP-1 offers life-changing benefits, sustainable health still hinges on balanced diets and regular physical activity. This episode provides a fascinating look at the intersection of science, medicine, and lifestyle in promoting longevity. Sign up for updates about each new episode: https://info.insidetracker.com/longevitybydesign View show notes here: https://blog.insidetracker.com/longevity-by-design-podcast-jens-juul-holst Episode highlights: Introduction: 00:00:00 What is GLP-1: 00:03:00 what is a GLP-1 agonist: 00:04:15 what are the target organs of the GLP-1 agonist?: 00:06:30 what is the effect of the GLP-1 agonist on a diabetic patient? : 00:10:00 What percentage of a diabetic patient on GLP-1 have complete remission: 00:11:30 How long did it take to bring a drug to market from the moment you first discovered it: 00:23:30 What is the GLP-1 effect on cognition and dementia: 00:29:00 GLP-1 effect on kidney diseases: 00:32:00 GLP-1 positive effect on fertility: 00:35:00 GLP-1 positive effect on cancer: 00:37:30 Should a patient be on GLP-1 for life: 00:41:00 GLP-1 related side effects: 00:48:00 GLP-1 effect on resting heart rate: 00:52:30 GLP-1 related side effects: 00:48:00 GLP-1 from Lilly vs novo nordisk: 00:55:00 GLP-1 oral versus the injectable: 00:58:00 GLP-1 effect on lifespan: 01:00:30 GLP-1 effect on lifespan: 01:00:30 What led you to become a scientist: 01:03:00 The story of discovering the GLP-1: 01:04:30 How did you successfully extend the half-life of the GLP-1 agonist: 01:09:00 GLP-1 moving from once a day to once a week: 01:16:00 Top tip to improve healthspan: 01:18:00 GLP-1 Agonists: A Game-Changer for Diabetes and Obesity Dr. Jens Juul Holst explores the revolutionary impact of GLP-1 agonists in treating diabetes and obesity. These medications mimic a natural gut hormone to regulate insulin secretion, appetite, and weight. Through their ability to normalize blood glucose levels and promote significant weight loss, GLP-1 agonists have transformed the lives of patients with type 2 diabetes and obesity. Holst highlights their success in enabling over 50% of diabetes patients to achieve normal glucose levels while addressing the systemic health risks tied to obesity. This innovation represents a monumental leap in metabolic disease management. Beyond Weight Loss: Cardiovascular and Inflammatory Benefits of GLP-1 Dr. Holst emphasizes the additional health advantages of GLP-1 agonists, beyond their effects on diabetes and obesity. These drugs improve cardiovascular outcomes by reducing major adverse events such as heart attacks and strokes. They also decrease systemic inflammation, a common issue in metabolic diseases. Holst points out that GLP-1 therapy’s dual action on vascular health and inflammation positions it as a comprehensive solution for improving long-term health outcomes in patients with diabetes or obesity. The Impact of GLP-1 on Fertility Dr. Holst explores GLP-1’s surprising potential in fertility treatments, particularly for individuals with metabolic-related infertility issues, such as polycystic ovary syndrome (PCOS). He explains that improving metabolism and reducing insulin resistance with GLP-1 therapy can enhance fertility outcomes for both men and women. Although he urges caution due to limited long-term data, Holst notes the promising effects observed in clinical experiences. “If you can ameliorate the metabolism of these individuals, they will immediately become pregnant. And we knew that already. You can even do it with metformin…Once GLP-1s were introduced, it turned out that yes, these people became pregnant.” We Appreciate You! As a token of our gratitude, we’re excited to offer you 15% off your next purchase. Simply click the link below to redeem your discount: https://info.insidetracker.com/podcast For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast
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Shark Tank Tru Bio Keto Gummies have been gaining popularity in the weight loss industry as a natural and effective way to shed pounds. These gummies are said to help curb cravings, boost metabolism, and promote fat burning, making them a promising option for those looking to slim down. But are they truly as effective as they claim to be?
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Shark Tank Tru Bio Keto Gummies are a dietary supplement that combines the power of keto with the convenience of a gummy. Keto, short for ketogenic, is a high-fat, low-carb diet that has been shown to help people lose weight by forcing the body to burn fat for fuel instead of carbohydrates. These gummies are designed to support the body in entering and maintaining a state of ketosis, where fat burning is optimized.
The ingredients in Shark Tank Tru Bio Keto Gummies are carefully chosen to help boost energy, suppress appetite, and enhance fat burning. Some of the key ingredients include BHB (Beta-Hydroxybutyrate) salts, Garcinia Cambogia extract, green tea extract, and MCT oil. These ingredients work together to help the body stay in ketosis, even when carbohydrates are consumed, making weight loss easier and more sustainable.
Users of Shark Tank Tru Bio Keto Gummies have reported experiencing increased energy levels, reduced cravings, and faster weight loss results. These gummies are easy to incorporate into a daily routine and can be taken anywhere, making them a convenient option for those with busy lifestyles. However, like any weight loss supplement, results may vary from person to person.
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One of the potential benefits of Shark Tank Tru Bio Keto Gummies is their ability to help suppress appetite and curb cravings. By reducing the urge to snack and overeat, these gummies may help users consume fewer calories overall, leading to weight loss. Additionally, the ingredients in these gummies are thought to help boost metabolism, which can further aid in burning fat and shedding pounds.
Another potential benefit of Shark Tank Tru Bio Keto Gummies is their convenience and ease of use. Unlike traditional weight loss supplements that come in pill form, these gummies are tasty and enjoyable to take. This can make sticking to a weight loss regimen more manageable and enjoyable, leading to better adherence and potentially better results.
Lastly, Shark Tank Tru Bio Keto Gummies may help users achieve and maintain ketosis more easily. The BHB salts in these gummies can help the body produce ketones, which are molecules that the body uses for energy when glucose levels are low. By supporting the body in entering ketosis, these gummies may help enhance fat burning and promote weight loss.
Potential Side Effects and Safety Concerns
While Shark Tank Tru Bio Keto Gummies are generally considered safe for most people, there are some potential side effects and safety concerns to be aware of. Some users may experience digestive issues such as stomach discomfort, bloating, or diarrhea when first starting these gummies. These side effects are typically mild and temporary, but if they persist, it’s advised to discontinue use and consult a healthcare professional.
Additionally, since these gummies contain caffeine from green tea extract, some users may experience jitteriness, insomnia, or rapid heartbeat. It’s important to monitor your caffeine intake from other sources and be mindful of any adverse reactions when taking these gummies. Pregnant or nursing women, as well as individuals with underlying health conditions, should consult with their healthcare provider before using Shark Tank Tru Bio Keto Gummies.
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As with any weight loss supplement, it’s essential to follow the recommended dosage and use these gummies as part of a healthy lifestyle that includes a balanced diet and regular exercise. While these gummies can be a helpful tool for weight loss, they are not a magic solution and should be used in conjunction with other healthy habits for best results.
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Shark Tank Tru Bio Keto Gummies offer a convenient and tasty way to support weight loss efforts through the power of keto. By helping the body enter and maintain ketosis, these gummies may aid in suppressing appetite, boosting metabolism, and promoting fat burning. However, results may vary, and it’s important to use these gummies as part of a comprehensive weight loss plan that includes healthy eating and regular exercise.
If you’re considering trying Shark Tank Tru Bio Keto Gummies, it’s essential to consult with your healthcare provider to ensure they are safe for you. By being mindful of potential side effects, following the recommended dosage, and incorporating these gummies into a healthy lifestyle, you may experience the benefits of enhanced weight loss support that these gummies have to offer.
Ultimately, while Shark Tank Tru Bio Keto Gummies may be a promising option for those looking to lose weight, it’s essential to approach them with realistic expectations and a commitment to making lasting changes for overall health and wellness.
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