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Yuanyuan Zhang, Alexei Kharitonenkov, and colleagues have developed QL1005, a GLP-1/GDF15 hybrid molecule with balanced pathway activation, which can effectively lower body weight via reductions in caloric intake in multiple animal models. In a non-human primate model of obesity, QL1005’s safety and tolerability are similar to that of incretin-based therapies. Check out the paper at http://www.cell.com/cell-metabolism/fulltext/S1550-4131(23)00001-3. Y. Zhang, X. Zhao, X. Dong, Y. Zhang, H. Zou, Y. Jin, W. Guo, P. Zhai, X. Chen, and A. Kharitonenkov (2023). Activity-balanced GLP-1/GDF15 dual agonist reduces body weight and metabolic disorder in mice and non-human primates. Cell Metab. 35. And read more great research at http://www.cell.com/cell-metabolism/home.

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