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With obesity becoming a growing concern worldwide, researchers are constantly seeking new ways to help individuals lose weight and improve their overall health. One potential solution that has been gaining attention in recent years is the use of semaglutide for weight loss. Semaglutide is a medication originally developed to treat type 2 diabetes but has shown promise in helping individuals shed excess pounds. In this article, we will explore the potential benefits of using semaglutide for weight loss, how it works, its effectiveness, potential side effects, and more.

How Semaglutide Works

Semaglutide belongs to a class of medications known as GLP-1 receptor agonists. These drugs work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) that is naturally produced in the body. GLP-1 helps regulate blood sugar levels by stimulating insulin production and reducing the secretion of glucagon, another hormone involved in blood sugar control. In addition to its effects on blood sugar, GLP-1 also plays a role in regulating appetite and food intake. By activating GLP-1 receptors in the brain, semaglutide can help individuals feel fuller sooner and eat less, leading to weight loss.

In addition to its effects on appetite and food intake, semaglutide also works to slow down the emptying of the stomach, which can further contribute to feelings of fullness and satiety. This can help individuals consume fewer calories overall, leading to weight loss over time. Semaglutide may also have other metabolic benefits, such as improving insulin sensitivity and promoting the breakdown of stored fat for energy.

Overall, the mechanism of action of semaglutide makes it a promising option for individuals who struggle with obesity and have been unsuccessful with traditional weight loss methods such as diet and exercise. By targeting multiple aspects of weight regulation, semaglutide may offer a more comprehensive approach to weight management for those in need.

Effectiveness of Semaglutide for Weight Loss

Several clinical trials have been conducted to evaluate the effectiveness of semaglutide for weight loss, and the results have been promising. In a study involving over 4,500 participants with obesity or overweight, semaglutide was found to lead to significantly greater weight loss compared to a placebo. Participants who received semaglutide lost an average of 15-20% of their body weight over the course of the study, which is a substantial amount compared to traditional weight loss interventions.

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Another study compared the weight loss effects of semaglutide to liraglutide, another GLP-1 receptor agonist commonly used for weight management. The results showed that semaglutide was more effective at promoting weight loss compared to liraglutide, further highlighting the potential of semaglutide as a powerful weight loss tool. These findings have led to the approval of semaglutide for weight management in some countries, providing individuals with a new option for achieving their weight loss goals.

It is important to note that while semaglutide can be effective for weight loss, it is not a magic bullet and should be used in conjunction with a healthy diet and regular exercise for optimal results. Additionally, individual responses to semaglutide may vary, and some individuals may not experience significant weight loss or may experience side effects that outweigh the benefits. Consulting with a healthcare provider is essential before starting any new weight loss medication, including semaglutide.

Potential Side Effects and Considerations

As with any medication, semaglutide comes with potential side effects and considerations that individuals should be aware of before starting treatment. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, which may improve over time as the body adjusts to the medication. These gastrointestinal side effects can be managed with dose adjustments or other interventions, so it is important to communicate any issues with your healthcare provider.

In rare cases, semaglutide has been associated with more serious side effects such as pancreatitis, gallbladder problems, and kidney damage. It is essential to monitor for any symptoms of these complications and seek medical attention if they occur. Individuals with a history of pancreatitis, gallbladder disease, or kidney problems may not be suitable candidates for semaglutide treatment, so a thorough medical evaluation is necessary before starting this medication.

Another consideration when using semaglutide for weight loss is the cost of the medication, as it can be expensive and may not be covered by all insurance plans. It is important to discuss the financial implications of semaglutide treatment with your healthcare provider and explore potential alternatives if cost is a barrier to access. Additionally, adherence to the prescribed dosing regimen is crucial for achieving the desired weight loss outcomes, so following your healthcare provider’s recommendations is key.

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Holly Lofton, MD, an obesity expert at NYU Langone Health, discusses the differences between GLP-1 agonists for weight loss and glycemic control. https://www.medscape.com/viewarticle/995911?src=soc_yt -TRANSCRIPT- I'm Dr Holly Lofton, clinical associate professor of surgery and medicine at NYU Langone Health, and I direct the medical weight management program. My practice is solely based on chronic weight management for adults. Today I'll talk about the various doses of GLP-1 agonists that you may prescribe to your patients. Being that this is based around weight management, I'll start with the weight management medications, the first of which is Saxenda. This is liraglutide 3 mg for chronic weight management. The studies that were done with this medication were intended to get the patient to the 3-mg dosing, which is what's prescribed for weight management, and not the 1.8-mg dosing which is prescribed for type 2 diabetes. However, you may deliver different doses to your patients depending on your goal. You see that this makes a lot of clicking noise. When the patient starts Saxenda and has their pen, there will be this clear fluid. It's important to remind them that this is a multiuse pen and that they should use it over and over again until it's empty. This medication has various doses in the same pen. You want to increase weekly as long as the patient is tolerating it. And by that, I mean not having significant side effects such as nausea, constipation, or other stool changes. When a patient receives the pen, it will start with 0. In the first week, we do 0.6 mg daily. The next week we do 1.2 mg daily. The third week we do 1.8 mg daily. The next week we do 2.4 mg daily, and then the goal is to get the patient to 3 mg, which is the maintenance dose. Ideally, the patient would stay there for their chronic weight management. However, if a patient can't tolerate the dose, you can also have them go to a lower dose for 7 more days and try again. Wegovy, which is semaglutide 2.4 mg, is also prescribed for chronic weight management. This is a single-use cartridge, so the pen will deliver only the dose that you prescribe to the patient. This as well is intended to increase monthly as long as the patient is tolerating it and not having too many significant GI side effects such as nausea, constipation, or loose stool. With this pen, the doses are 0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg. You increase it monthly or every 4 weeks, depending on the patient tolerance. However, if a patient is not able to tolerate the highest dose, you can prescribe the maximally tolerated dose for that patient. The next new GLP-1 I'll talk about is Ozempic [semaglutide] prescribed for type 2 diabetes. The goals of titrating this medication really depend more on your patient's glycemic control, as this is used for glycemic management. Here we have the red labels and big pen, and this delivers either 0.25 mg or 0.5 mg. The recommendation for this medication is to use 0.25 mg for 4 weeks. Assess the patient's glycemic control, and if needed, increase to 0.5 mg after 4 weeks. Again, this pen delivers either 0.25 mg or 0.5 mg only. This blue-green–label Ozempic [semaglutide] delivers 1-mg dosing, so when your patient turns this one all the way to the end, the only number they will see will be 1. If your patient does not have optimal glycemic control with the lower doses, a 1-mg pen can be prescribed and the patient can continue on that, optimizing their glucose, or you can increase to a 2-mg pen [yellow label], which delivers only 2 mg. This is a single-use cartridge for Trulicity [dulaglutide]. The various doses of Trulicity are 0.75 mg, 1.5 mg, 3 mg, and 4.5 mg. This pen will deliver only the dose that's prescribed, and you can titrate up to optimize glycemic control for your patient. The higher the dose, the better the improvement in glucose and hemoglobin A1c. This is the pen for Mounjaro, which is tirzepatide. At the time of this recording, this medication is intended for type 2 diabetes management. It's a single-use cartridge, and the different doses vary from 2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, to the highest dose, 15 mg. Again, this should be titrated to optimize glycemic control for your patient, and you can increase or decrease the dose based on the patient's tolerance. https://www.medscape.com/viewarticle/995911?src=soc_yt

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In episode 32 of The Functional Code, Dr. Addy and Dr. Jace delve into GLP-1 agonists like semaglutide and terzepatide, exploring their roles in weight loss and diabetes management. They discuss the mounting reliance on these medications, citing real-life examples and addressing societal and cultural impacts on health. The podcast also covers the historical adjustments to hypertension markers, the projected rise in obesity and diabetes by 2050, pharmaceutical influences, and strategies for utilizing GLP-1 agonists effectively. Listeners are encouraged to take a proactive role in their health, with insights into potential side effects, complementary strategies like resistance training and adequate protein intake, and the importance of building healthy habits. Dr. Jace Nybo D.C. Dr. Addy Knutson D.C. Guide: 00:00 The Hunger Zombie Incident Intro 01:08 Welcome to the Functional Code 01:37 Introduction to GLP-1 and Weight Loss 03:33 The Obesity Epidemic 06:34 Pharmaceutical Influence and Misleading Practices 09:07 Childhood Obesity and Long-Term Health Risks 17:34 Traditional and Surgical Interventions for Obesity 21:06 The History of Diabetes and Weight Loss Medications 28:31 Understanding GLP-1 Mechanisms 36:11 The Impact of GLP-1 on Health 39:30 Misguided Medical Advice and Patient Preparation 40:42 The Hunger Zombie Phenomenon 41:28 Advancements in Weight Loss Medications 44:07 Long-Term Use and Side Effects 59:27 The Importance of Resistance Training and Protein Intake 01:02:44 Proper Management and Use of Weight Loss Medications 01:06:47 Future Developments and Final Thoughts 01:11:54 Conclusion and Final Remarks Resources: doi.org/10.1136/bmj-2023-078225 doi.org/10.1186/s12933-023-01765-z doi.org/10.1016j.molmet.2020.101102 Instagram: instagram.com/thefunctionalcode/ TicTock: @thefunctionalcode Apple Podcast: podcasts.apple.com/us/podcast/the-functional-code-podcast/id1754585557