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At the European Society for the Study of Diabetes (EASD) Annual Meeting in Barcelona, Steve Bain discusses the major challenges in developing an oral GLP-1 receptor agonist and how was this overcome with semaglutide. 1. What were the major challenges in developing an oral GLP-1 receptor agonist and how was this overcome with semaglutide? (0:05) 2. Is the oral formulation likely to replace other injectable GLP-1 receptor agonists? (2:12) 3. What have been the key take home messages from the PIONEER clinical trial programme? (3:02) 4. How does oral semaglutide compare with other oral agents such as empagliflozin and sitagliptin? (4:44) 5. Which patients are most likely to benefit from oral semaglutide? (5:37) Steve Bain has no conflicts of interest to declare in relation to this video. Filmed at the Annual Meeting of the European Association of the Study of Diabetes (EASD) Barcelona, Spain 2019.

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