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Click Here to Subscribe: http://Bit.ly/ThomasVid Website: http://ThomasDeLauer.com Massive Discount on Locally Sourced Grassfed Beef Right to Your Door: https://www.farmfoodsmarket.com/discount/THOMAS2018 How Fasting Burns Fat: Activate Fat Burning Enzymes- Thomas DeLauer… Norepinephrine and Epinephrine: Adrenaline is released from the adrenal cortex & goes through the bloodstream to affect numerous tissues in the body. Noradrenaline is released from the nerve terminals and is the main neurotransmitter of the sympathetic nerves in the cardiovascular system. These two play a primary role in the breakdown of fat by binding to the beta-1 and 2 receptors in the body, which increases cAMP levels which in turn increases fat breakdown. The nervous system sends norepinephrine to the fat cells, making them break down body fat into free fatty acids that can be burned for energy (1,2) Hormone Sensitive Lipase: Fasting increases the activation of hormone sensitive lipase Activating hormone sensitive lipase initiates lipolysis, the breaking down of triacylglycerols into free fatty acids and glycerol (3) Glucagon: Fasting also increases glucagon levels, which breaks down fat - glucagon is a hormone that acts directly opposite to insulin (the pancreas secretes it in an effort to raise blood sugar levels) While insulin stores carbs and builds fat, glucagon is responsible for breaking down stored carbs and fats and releasing them so your body can use them for energy (4) How They All Work Together: The only site for regulation of fatty acid oxidation is at the level of hormone-sensitive lipase in adipose tissue. Under fasting conditions, with minimal insulin in the blood, glucagon promotes formation of the active form of hormone-sensitive lipase. When epinephrine is present, it further actives hormone-sensitive lipase, increasing the hydrolysis of triglycerides to produce free fatty acids (FFA) and glycerol. The glycerol is carried to the liver, where it enters gluconeogenesis, while the FFA are carried on serum albumin to the tissues where they are catabolized for energy. The liver uses some of the energy from fat mobilization to support gluconeogenesis (5) Additional: Ketone Production: Burn Fat Instead of Sugar- Fasting shifts your metabolism from burning sugar to burning fat - begins to break down triglycerides in the form of ketones. References: 1) Zauner C , et al. (n.d.). Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/10837292 2) Jensen MD , et al. (n.d.). Lipolysis during fasting. Decreased suppression by insulin and increased stimulation by epinephrine. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/3540009 3) Sztalryd C and Kraemer FB. (n.d.). Regulation of hormone-sensitive lipase during fasting. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/8141275 4) Marliss EB , et al. (n.d.). Glucagon levels and metabolic effects in fasting man. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/5480852 5) Hormone-sensitive lipase - an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/neuroscience/hormone-sensitive-lipase 6) Adrenalin and Noradrenalin The 'Dynamic Duo? (2015, April 9). Retrieved from https://thefatlossmanifesto.com/adrenalin-and-noradrenalin-the-dynamic-duo/

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Curious about GLP-1 medications? Dr. Chhaya Makhija, MD, Endocrinologist and Diabetes Specialist, breaks down what GLP-1 (glucagon-like peptide-1) is, how it works in the body, and what side effects you should really expect. GLP-1 medications aren’t new—they’ve been helping patients since the late 2000s! In this video, Dr. Makhija explains how GLP-1 slows down stomach contractions to help you feel fuller, changes appetite signaling, and even impacts metabolism and visceral fat. Wondering about side effects? Dr. Makhija shares the real-world experience: nausea is common at first, but usually fades after a few weeks. Vomiting is rare, especially when starting at low doses, and constipation is more likely than diarrhea due to the way GLP-1 slows gut movement. Get clear, expert advice on what to expect and how to manage these medications safely. Subscribe for more endocrinology insights and upcoming webinars! #GLP1 #DiabetesCare #Endocrinology #WeightLossMedications #DrChhayaMakhija #HealthEducation

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