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The psychiatric events associated with GLP1 receptor agonist medications are likely driven by low nutrient levels as is seen with overtraining and rapid weight loss since GLP1 by themselves are beneficial for the brain: https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2020.01270/full

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Can the Microbiome Replace Ozempic? Two Experts Weigh In on a Radical Theory with Dr. Gary Pepper & Mary Gocke, RDN, CDN, CHT Are we overlooking the natural power of the gut microbiome in managing weight and metabolism? In this eye-opening conversation, Dr. Gary Pepper — a seasoned endocrinologist — teams up with renowned nutritionist and functional medicine expert Mary Gocke to explore whether the body’s own microbiome might one day rival pharmaceutical GLP-1 drugs like Ozempic and Wegovy. From nutritional strategies to protect muscle and bone during weight loss, to the role of akkermansia and polyphenols in boosting natural GLP-1 production, this discussion offers a radically fresh perspective on sustainable metabolic health. Topics covered in this episode include: What GLP-1 medications like Ozempic actually do — and what they don’t Why weight loss can lead to malnutrition, muscle loss, and even bone density decline How the gut microbiome — especially Akkermansia muciniphila — may support natural GLP-1 production The critical importance of dietary fiber, polyphenols, and prebiotics in metabolic health How protein needs shift during rapid weight loss and how to calculate your target intake Early evidence for and against the long-term use of GLP-1 drugs The promising but controversial concept of microdosing and tapering off GLP-1s Simple strategies to protect your body from the side effects of medical weight loss Why resistant starches (like cooled potatoes and rice) might actually help your microbiome The silent risk of osteoporosis from poorly managed weight loss Whether you're currently on a GLP-1 medication, considering one, or exploring natural alternatives, this candid and science-based conversation will equip you with insights not found in mainstream media. 👉 Visit semagludiet.com to try the free Protein Intake Calculator tailored to your age, weight, activity level, and dietary needs. 📌 For educational purposes only. Always consult your healthcare provider before making changes to your medical or nutritional plan.
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