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CardioNerds (Drs. Gurleen Kaur and Richard Ferraro) and episode FIT Lead Dr. Spencer Carter (Cardiology Fellow at UT Southwestern) discuss the clinical implementation of GLP-1 receptor agonists with Dr. Neha Pagidapati (Faculty at Duke University School of Medicine). In this episode of the CardioNerds Cardiovascular Prevention Series, we discuss the clinical implementation of glucagon-like peptide-1 (GLP-1) receptor agonists. We cover the clinical indications, metabolic and cardiovascular benefits, and potential limitations of these emerging and exciting therapies. Show notes were drafted by Dr. Spencer Carter. Audio editing was performed by CardioNerds Academy Intern, student Dr. Pacey Wetstein. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - Clinical Implementation of GLP-1 Receptor Agonists GLP-1 agonists work through a variety of mechanisms to counteract metabolic disease. They increase insulin secretion, inhibit glucagon secretion, slow gastric motility, and increase satiety to limit excess energy intake. Patients with type II diabetes and an elevated risk for atherosclerotic cardiovascular disease should be considered for GLP-1 agonist therapy regardless of hemoglobin A1c. GLP-1 agonists offer significant ASCVD risk reduction even in the absence of diabetes. Newer data suggest a significant reduction in cardiovascular events with GLP-1 agonist therapy in patients who are overweight or obese and have a prior history of heart disease. GLP-1 agonists should generally be avoided in patients with a history of medullary thyroid cancer or MEN2. As these medications slow gastric emptying, relative contraindications include history of recurrent pancreatitis and gastroparesis. GLP-1 agonists should be initially prescribed at the lowest dose and slowly uptitrated to avoid gastrointestinal side effects. Show notes - Clinical Implementation of GLP-1 Receptor Agonists What were the groundbreaking findings of the STEP1 and SURMOUNT-1 trials and how these impact cardiovascular wellness? The STEP1 and SURMOUNT trials demonstrated sustained clinically relevant reduction in body weight with semaglutide and tripeptide, respectively, in patients with overweight and obesity. As obesity is an important risk factor for the development of cardiovascular disease, weight reduction meaningfully contributes to cardiovascular wellness. What were the findings of the LEADER trial and their implications for patients with type II diabetes and high cardiovascular risk? The LEADER trial demonstrated a significant reduction in the rate of cardiovascular death, nonfatal MI, or nonfatal stroke in patients with type II diabetes treated with liraglutide. GLP-1 receptor agonist therapy should be considered in all patients with type II diabetes and elevated ASCVD risk regardless of A1c or current hyperglycemic therapy. What are current indications for GLP1 agonists in the context of cardiometabolic disease. GLP-1 receptor agonists should be considered in patients with type II diabetes and high ASCVD risk OR patients without diabetes who are overweight/obese and have a history of cardiovascular disease. What are important side effects or contraindications to GLP1 agents when used for cardiovascular risk reduction and wellness? GLP-1 receptor agonists should be avoided in patients with a history of medullary thyroid cancer or MEN2. Relative contraindications include recurrent pancreatitis, gastroparesis,

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Welcome back to my channel! In this video, I take you through my transformative GLP-1 weight loss journey. I’ll share the ups and downs, the challenges I faced, and the incredible results I achieved using GLP-1 medications. Learn about the science behind how these medications work, my tips for integrating them into a healthy lifestyle, and what you can expect if you decide to take this path. Whether you're struggling with weight loss or just curious about GLP-1, this video is packed with valuable information and personal anecdotes. Don’t forget to like, subscribe, and leave a comment with your thoughts or questions! #GLP1 #WeightLossJourney #HealthyLiving #Inspiration

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Magnesium is involved in hundreds of biochemical reactions that help prevent common problems such as atrial fibrillation, high blood pressure, insomnia, heart disease, leg cramps, and fatigue. Many people are magnesium deficient, but it’s almost impossible to test! Only 1% of your magnesium is in the blood—the rest is inside the cells. Some common causes of magnesium deficiency include: •Genetic weakness •Low stomach acid •Prediabetes or diabetes Magnesium depends on vitamin D, which many people have a genetic problem with. Vitamin D deficiency inhibits the proper function of magnesium in the body. You need a minimum of 10,000 IU of vitamin D daily. Magnesium glycinate has an 80% absorption rate and also helps with sleep. Magnesium controls calcium, so you likely have excess calcium if you're magnesium deficient. Too much calcium causes cramping in the calves, high blood pressure, and arrhythmias. Smoking, alcohol, soda, refined sugars, starches, and certain medications can all contribute to a magnesium deficiency. Leafy greens, pumpkin seeds, chocolate, and nuts are the best food sources of magnesium. You won't see results if you don’t give magnesium enough time to work. It takes at least 1 to 3 months to see results from magnesium. Digestive issues like constipation or diarrhea can greatly affect your ability to absorb magnesium. Chronic stress and exercise can increase your magnesium requirements. You can increase magnesium absorption by spreading your doses throughout the day rather than taking it all at once. Try drinking apple cider vinegar mixed with water to acidify the stomach and increase magnesium absorption. Dr. Eric Berg DC Bio: Dr. Berg, age 59, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. #Keto #ketodiet #weightloss #ketolifestyle Thanks for watching! Try to avoid these mistakes when taking magnesium supplements. I’ll see you in the next video. Transkript Du kannst im Transkript mitlesen.

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