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Altimmune’s experimental weight loss drug pemvidutide minimized the loss of muscle mass while losing weight, mimicking the effects of diet and exercise, according to the results of a small trial by the company, amid efforts by biotech firms to study how increasingly popular weight-loss drugs can maintain muscle mass. Other popular weight-loss drugs have been studied for their ability to maintain muscle mass while helping patients lose weight. During a 68-week trial of semaglutide, the active ingredient in Ozempic and Wegovy, over 1,300 participants using the drug lost an average of nearly 15 pounds of lean muscle and 23 pounds of fat. BioAge Labs announced last year it would be testing its muscle loss drug azelaprag with Mounjaro to treat obesity, after an early trial indicated azelaprag could help prevent muscle atrophy. Additional data from Altimmune’s mid-stage trial will be presented at an unspecified upcoming event, the company said. Results from a study involving pemvidutide’s treatment of MASH are expected in the first quarter of 2025. All data is taken from the source: http://forbes.com Article Link: https://www.forbes.com/sites/tylerroush/2024/03/27/what-to-know-about-permvidutide-altimmune-says-weight-loss-drug-minimized-muscle-mass-loss-in-trial/ #newscnn #newstodayupdate #newstodayabc #bbcworldnewstoday #usanewstoday #newsworldtoday #

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Tirzepatide and semaglutide are two medications that have gained significant attention in the medical community for their potential weight loss benefits. Both drugs are classified as glucagon-like peptide-1 receptor agonists, which work by mimicking the action of a hormone called GLP-1. This hormone helps regulate blood sugar levels, and it also plays a role in appetite control and satiety. As a result, medications that target the GLP-1 receptor have shown promise in helping individuals achieve weight loss.

Comparing Tirzepatide and Semaglutide

When it comes to weight loss, tirzepatide and semaglutide are often compared to each other due to their similar mechanisms of action. However, there are some key differences between the two medications that are important to consider when deciding which one may be more suitable for an individual’s weight loss goals. In this article, we will explore the differences between tirzepatide and semaglutide in terms of their efficacy, safety profile, dosing regimens, and side effects.

Efficacy

One of the most important factors to consider when comparing tirzepatide and semaglutide is their efficacy in promoting weight loss. Both medications have been shown to be effective in helping individuals lose weight, but the degree of weight loss may vary between the two drugs. Clinical trials have demonstrated that tirzepatide may lead to greater weight loss compared to semaglutide. In a phase 2 trial involving individuals with obesity, those who received tirzepatide experienced significantly more weight loss than those who received semaglutide.

Safety Profile

Another important consideration when comparing tirzepatide and semaglutide is their safety profile. Both medications are generally well-tolerated, but they may have different side effect profiles that could impact tolerability and adherence. Common side effects of both drugs include nausea, vomiting, diarrhea, and dizziness. However, tirzepatide may be associated with a lower incidence of gastrointestinal side effects compared to semaglutide. Additionally, semaglutide has been linked to a rare but serious side effect known as pancreatitis, which is important to consider when weighing the risks and benefits of treatment.

Dosing Regimens

The dosing regimens of tirzepatide and semaglutide also differ, which can impact convenience and adherence to treatment. Semaglutide is typically administered once weekly via subcutaneous injection, while tirzepatide is given once weekly or once every two weeks. Some individuals may find the less frequent dosing of tirzepatide more convenient, while others may prefer the simplicity of once-weekly dosing with semaglutide. It is important to consider individual preferences and lifestyles when choosing between the two medications.

Side Effects

In addition to gastrointestinal side effects, both tirzepatide and semaglutide may have other potential side effects that need to be considered. For example, both drugs have been associated with an increased risk of hypoglycemia, which can be a concern for individuals with diabetes or those taking other medications that lower blood sugar levels. Other potential side effects of tirzepatide and semaglutide include injection site reactions, allergic reactions, and changes in kidney function. It is essential to discuss all potential side effects with a healthcare provider before starting treatment with either medication.

Conclusion

In conclusion, tirzepatide and semaglutide are two medications that show promise in promoting weight loss. Both drugs work by targeting the GLP-1 receptor and have been shown to be effective in clinical trials. However, there are some differences between tirzepatide and semaglutide in terms of their efficacy, safety profile, dosing regimens, and side effects. Individuals considering treatment with either medication should consult with a healthcare provider to determine which option may be more suitable for their weight loss goals and individual needs.

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I had a conversation with Jordan Syatt who is an extremely successful Online Strength and Nutrition coach, he also has over half a million followers on his instagram alone due to his incredible nutrition and fitness content. Jordan is a short, bald, Jewish guy with an affinity for Deadlifting and also happens to be Gary Vaynerchuk's personal trainer. He wasn't sure what else to put in his bio (nor did he enjoy writing this in the third-person) so he'll end it here. That said, he's an open book and you can ask him, literally, anything you want. Also, as of this moment Jordan is looking to hire someone to help him write his bio. All help welcome. DURING THIS EPISODE WE TALK ABOUT: What inspired Jordan to get into the world of health, fitness and nutrition. How Jordan became Gary Vaynerchuk’s personal trainer and the impact this had on his life. The sacrifices Jordan had to make to build a huge social media following and an online fitness business. The pros and cons of losing body fat quickly. The different methods Jordan uses with his clients when it comes to losing body fat and building muscle. Why Jordan achieves better results with online clients as opposed to when he used to train people face to face. Why meal plans fail people most of the time when it comes to shifting body fat, building muscle and overall health. Jordan’ experience with his recent challenge of eating 1 Big Mac per day for 30 days. A calorie deficit for fat loss explained. Why adequate protein is important whilst in a calorie deficit for fat loss. Why meal frequency does not matter for fat loss and muscle gain. Jordan’s take on eating meat vs following a vegan diet. Jordan’ top tips for getting in shape and achieving sustainable health. Get you free fat loss fundamentals guide 👇🏼 optimiseyourbody.com/free-guides/ Online nutrition and fitness coaching enquires: [email protected] RATINGS & REVIEWS If you liked this episode then please head over to iTunes to give this podcast a rating and review, this is the best way for this podcast to reach more people and help them optimise their body. Also please share this podcast link to any friends or family who you think will benefit from this podcast. WHERE ELSE CAN I LISTEN TO THIS PODCAST Currently, you can listen to this podcast on iTunes, Spotify, Stitcher or Castbox.

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Join us as we dive into the world of GLP-1 medications for weight loss! 🌟 Discover how medications like semaglutide (Wegovy® or Ozempic®) can help regulate appetite, slow digestion, and promote lasting weight loss results. 💪 Our compounding pharmacist, Robin, breaks down the science behind GLP-1 medications and explores innovative alternatives, including sublingual semaglutide. Whether you're considering injectable or needle-free options, we've got you covered! Learn more about GLP-1 medications and their role in personalized weight management on our blog. If you're ready to take the next step on your weight loss journey, reach out to our team today! 📞 #GLP1Medications #WeightLossJourney #Semaglutide #CompoundingPharmacy #HuberHeightsOH 🍎💉