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In this video, we go over the GLP-1 RAs and what you need to know when prescribing these medications. As always, thank you for tuning in and if you haven't already, SUBSCRIBE & DING that notification bell so you don't miss an upload! Download The FREE NP Diabetes Starter Pack: https://adept-creator-4162.ck.page/diabetesstarterpack HELPFUL VIDEO: -https://youtu.be/Kzi2Eojn8do ~~~~~~~~~~~~ //SHOP MY NURSING GEAR: -Nursing Apparel: https://teespring.com/stores/kim-e-the-diabetes-np //MY AMAZON NURSING FAVORITES: -The Art & Science of Diabetes Self-Management Education Desk Reference: https://amzn.to/2JfxU0M -My Stethoscope: https://amzn.to/33M3vRg -My Stethoscope Case: https://amzn.to/2QNOnh3 -Lab Pocket Guide: https://amzn.to/33LZlJ9 -The Sanford Guide to Antimicrobial Therapy 2019: 50 Years: 1969-2019 1st Edition: https://amzn.to/39oeLUU **Disclaimer: I receive commission off of sales made through the links above. This does not cost you any extra & I appreciate your support SO much!** ~~~~~~~~~~~~~~ TO SUBMITS QUESTIONS & VIDEO REQUESTS: -https://www.ellisdiabetes.com/contact LET'S CONNECT: ~INSTAGRAM: https://www.instagram.com/thediabetesnp/ ~TWITTER: https://twitter.com/thediabetesnp //QUESTIONS, VIDEO REQUESTS, or COLLABS: https://www.ellisdiabetes.com/generalinquiries //BOOK KIM TO SPEAK: Want Kim to teach more in detail at your private event⤵️ https://www.ellisdiabetes.com/bookingrequests ~~~~~~~~~~~~~~~~~~~~~~~~~~~~~ Welcome to Kim E. The Diabetes NP Channel!!! My name is Kim E. and I have a love and passion for prediabetes and Diabetes Mellitus Type 2. I went on a journey a while ago to build upon my knowledge of the disease and found it difficult to find concise and useful information. I realized at that moment that we, as nurse practitioners, needed a resource like this. As I began learning more about the disease and the new advances in education and management, I wanted to be apart of the solution for my fellow colleagues. If this is something that interests you, please come along with me as we grow in our knowledge of Diabetes to better serve our patients. Submit questions & video requests to [email protected]. ~~~~~~~~~~~ DISCLAIMER FOR PATIENTS: The information on this platform is to serve as general education for diabetic patients. It IS NOT intended to be a substitute for seeking professional medical care. In fact, Kim E. urges you to have a consistent management and follow up relationship with your primary care provider (PCP). NOTE: Please understand that though Kim E. is very knowledgeable in the area of diabetes, there is no way that she would be able to know every patient's past medical history, co-morbidities, and complications that view her videos. She claims no liability or responsibility for your health and medical conditions as that is the responsibility of your primary care provider. The purpose of the videos are for educational purposes ONLY and NOT for EVALUATION, DIAGNOSING, or TREATING those with diabetes. If you have any questions further than what is covered in the GENERAL educational videos, follow up with your primary care physician. All content is for general educational purposes only and should be used to augment your knowledge. DISCLAIMER FOR PROVIDERS: The information and services on this platform are to serve as an adjunct resource to your nursing practice. They ARE NOT intended to be a substitute for professional judgement. REMEMBER: You know your patient population and their specific needs and conditions. Please understand that though I am very knowledgeable in the area of diabetes, I do not know every patient's past medical history, co-morbidities, and complications. Use your clinical discernment as to what treatment is best for each of your patients. All content is for general educational purposes only and should be used augment your knowledge.

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The Beginning of a Transformational Journey

The weight loss journey often begins with a personal moment of reflection, and for many, this moment can profoundly shape the course of their lives. In the case of the Jelly Rolls 120-pound weight loss transformation, it all started with the realization of one’s health status and the impact weight had on every aspect of life. This journey reflects not only the physical changes gained through dedication and effort but also the emotional and mental shifts that accompany such a deep transformation. The desire for change stemmed from a mixture of health concerns, self-image issues, and an overwhelming urge to embrace life fully. This journey is about more than just numbers on a scale; it’s about finding one’s true self again, regaining confidence, and achieving a heart-healthy lifestyle.

Embarking on this weight loss journey required a courageous leap into the unknown, which can be intimidating for many. The decision to lose weight wasn’t solely about aesthetics; it was a conscious choice rooted in the need for better heart health and an overall sense of well-being. For individuals struggling with obesity, every extra pound can feel like a barrier to achieving life goals, participating in activities, and enjoying moments that others take for granted. This backdrop of personal motivations is crucial because it sets the tone for how deeply someone may commit themselves to a weight-loss regime. With concern about health issues looming over, such as diabetes and heart disease, the stakes felt higher than simply fitting into old clothes or looking good in photos.

Support systems play an influential role in the success of any weight loss journey. Whether it’s family, friends, or a fitness community, having a network to encourage and motivate can make a significant difference. Through sharing experiences, successes, and even setbacks, the journey started to feel less isolating. This bond with like-minded individuals created a sense of accountability, igniting passion and dedication toward achieving weight loss goals. As connections were forged, not just on the physical level but also emotionally and mentally, the journey became as much about unity and support as it was about personal achievement. Ultimately, this transformation was about individuals coming together with shared experiences, motivations, and the collective wish to lead healthier lives for the sake of themselves and their families.

A Commitment to Change

The journey toward losing 120 pounds is rarely smooth or linear; it requires a commitment to change. This deep commitment often begins with setting realistic goals that are manageable and attainable. Instead of aiming for weight loss in drastic measures, adopting a gradual approach promotes sustainability. This could include small changes in diet or incorporating physical fitness into daily routines. It is all about creating lifelong habits rather than short-term fixes. Developing a stronger relationship with food is another integral part of this commitment. Learning about nutritional values, portion control, and mindful eating goes a long way toward promoting a balanced lifestyle.

In addition to dietary changes, committing to a structured exercise regime is also pivotal in shedding pounds. Finding a physical activity that sparks joy can be a powerful motivator. This could vary from dancing, swimming, jogging, or joining a local sports team. Engaging in activities that bring happiness makes the consistency that weight loss requires much easier to maintain. Ensuring workouts are enjoyable prevents the feeling of burden or obligation. Regular exercise builds strength and endurance and can improve mental clarity and emotional stability, further supporting the journey of transformation.

The importance of setting milestones should not be underestimated. These milestones act as benchmarks to celebrate along the way, making the lengthy journey seemingly shorter and fostering motivation. Reaching every 10 or 20 pounds lost can serve as a time to reflect on achievements, recalibrate goals, and boost morale for subsequent efforts. Each milestone offers the chance to reassess what worked and what did not while providing an invaluable opportunity to celebrate both physical changes and personal growth. Embracing this journey in increments allows for recognition of hard work while also highlighting transformative gains in health and self-confidence.

Overcoming Obstacles with Resilience

<pNo weight loss journey is without its challenges. On the path to losing 120 pounds, numerous obstacles inevitably arise, ranging from emotional hurdles to physical limitations. Often, the mental aspect of weight loss can be just as arduous as the physical. Dealing with cravings, feelings of self-doubt, and occasional setbacks are natural experiences faced along the way. Understanding that progress is rarely linear empowers individuals to navigate through tough times with resilience. Instead of fueling negative thoughts, focusing on the positive changes and benefit experienced so far can help in regaining motivation and confidence. Embracing this mindset prepares one to face stumbling blocks head-on, fostering a sense of determination.

Another common hurdle is the social aspect of weight loss. Many individuals face judgment from friends or family, challenges when eating out, or feelings of isolation. This is especially true when going through significant lifestyle changes. Educating loved ones about personal health goals and the reasons behind lifestyle changes can create understanding and support. Open communication invites allies into the journey rather than detractors, as it builds a foundation of caring and encouragement. Passionately sharing the excitement and progress helps in garnering support from those around which can brighten dark moments and provide necessary reminders of why the journey began.

Physical challenges can also arise, which some may not anticipate when embarking on a weight loss journey. Fitness plans should be tailored according to individual capabilities, easing into regular physical activity to accommodate initial limits and prevent injury. This can include starting with light exercises, such as walking or gentle yoga and gradually increasing intensity as endurance builds. Listening to one’s body is crucial; rest days are just as vital as workout days in recovery. It’s about embracing a lifestyle that celebrates movement while respecting the body’s needs. Building strength and endurance might take time, but patience in the process brings about biological adaptations to support a healthier life.

The Role of Nutrition in the Transformation

Food plays a significant role in any weight loss journey, especially when aiming to lose 120 pounds. Understanding and implementing nutritional fundamentals can be empowering. Shifting focus away from restrictive dieting launches individuals into a world of healthy, enjoyable food choices. Emphasizing fruits, vegetables, lean proteins, and whole grains is essential; these foods not only fuel the body but also provide necessary nutrients for overall well-being. Meal prepping and planning can simplify achieving daily nutritional goals, making it easier to avoid impulsive, unhealthy food decisions.

Another crucial aspect of transformation is overcoming the stigma attached to certain foods. Many individuals associate some foods with guilt or shame; reversing this narrative promotes a healthier attitude toward eating. It involves balancing indulgence with nutritious practices and finding satisfaction in moderation, rather than strict abstinence. This perspective can help foster a sustainable relationship with food, allowing the journey to include occasional treats without derailing overall progress. Educating oneself on nutritional value fosters informed choices, enhancing satisfaction and nourishment rather than creating a sense of deprivation.

Developing cooking skills is another beneficial aspect that emerges from the focus on nutrition. Experimenting in the kitchen opens the door to discovering new methods to prepare healthy meals, increasing creativity and interest in what goes on the plate. Engaging with food on a deeper level can also lead to a renewed appreciation for both flavors and textures, thus transforming eating from a chore into an enjoyable experience. From incorporating more vegetables and spices to exploring diverse culinary traditions, healthy eating becomes more than a routine; it can evolve into a passion that fuels the transformation process.

Celebrating the Successful Transformation

After the thrilling ride of losing 120 pounds, celebrating achievements is essential. Acknowledging how far one has come validates the hard work, sacrifice, and effort put into the journey. Celebrations can take many forms, be it treating oneself to new clothes that reflect the change, planning a special getaway, or celebrating health milestones by engaging in activities once deemed impossible. These moments create lasting memories that symbolize dedication and perseverance, reinvigorating motivation for continued health goals post-transformation.

Moreover, sharing your story can inspire others. The journey of weight loss speaks volumes and encourages those who may be on the verge of beginning their path. Whether it’s through social media platforms, community discussions, or group meet-ups, telling one’s story can create an empowering ripple effect. By offering insights into personal challenges, victories, and learnings, individuals can connect with others seeking motivation, creating a newfound sense of purpose beyond personal achievement. This transition from self-focus to community inspiration encapsulates the beautiful nature of this journey.

Lastly, it’s important to remember that transformation is an ongoing process. After achieving such a significant milestone, maintaining a healthy lifestyle holds equal importance to initial weight loss. Integrating new habits into everyday life ensures that success is sustained long after the active weight loss phase ends. This might entail setting new health goals, continuing to engage with a supportive community, and regularly reflecting on personal motivations. Embracing change as a continuous process allows individuals to thrive not only in terms of their weight but in overall health and well-being, fostering a lifestyle filled with happiness and vitality for years to come.

Reflecting on a Journey of Health and Heart

As final reflections on this inspiring weight loss journey emerge, it is crucial to emphasize the transformative power of dedication, resilience, and community support. By looking back at the motivations that sparked the initial desire for change, one can appreciate how that spark ignited a profound transformation of heart and health. This journey is not just about losing pounds but about rediscovering oneself, fostering a lifestyle built on health and vitality. It is a reminder that change can be achieved, no matter the size of the challenge, through commitment and passion.

The culture surrounding weight loss often highlights physical transformations as the most significant accomplishments. However, the emotional and mental changes associated with the journey deserve equal attention. The boosted self-esteem, newfound confidence, and emotional satisfaction greatly impact everyday life. Committing to regular physical activity, understanding nutrition, building resilience against obstacles, and nurturing connections with a supportive community reshapes one’s identity from within, creating a well-rounded sense of self and well-being.

Ultimately, the journey serves as a tribute to the saying, “health is wealth,” as it emphasizes the benefits of making informed choices. The Jelly Rolls transformation illustrates that when individuals honor their bodies and prioritize their health, they not only change looks—they alter the fabric of their lives. This journey is neither a sprint nor a finish line, but an evolution, a lifelong commitment to health that inspires not only personal growth but also cultivates a positive ripple effect that encourages others along the way. As the story continues, one cannot help but celebrate the richness that comes from pursuing a heart-healthy lifestyle.

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Partial or biased agonism to improve GLP-1 receptor agonist properties by Ben Jones, Clinical Senior Lecturer Imperial College London I will discuss our work aiming to understand whether the therapeutic properties and side effect profile of GLP-1R agonism can be improved by refining intracellular signalling properties. Ben Jones is a Clinical Senior Lecturer within the Section of Endocrinology and Investigative Medicine, and a Consultant in Metabolic Medicine based in Imperial College Healthcare NHS Trust and North West London Pathology. His research is focused on the translational pharmacology of G protein coupled receptors in metabolic disease. He completed his undergraduate medical training at the University of Cambridge in 2006, and was a Foundation and Core Medical trainee on the Cambridge and Oxford rotations, respectively. In 2010 he moved to Imperial as an Academic Clinical Fellow in Metabolic Medicine. He was awarded an MRC-funded Clinical Research Training Fellowship in 2013 (supervisors: Prof Steve Bloom and Prof Tricia Tan), during which he applied the emerging concept of "biased agonism" to the GLP-1 receptor. After completing clinical training in 2020 he has was awarded the Imperial Post-Doctoral, Post-CCT Fellowship (IPPRF), and subsequently an MRC Clinician Scientist Fellowship. Current work aims to establish the mechanism of action of “biased” incretin receptor agonists, and how their unusual effects can be exploited therapeutically in diabetes and obesity. https://thelongevityforum.com