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Peptidic GLP-1R agonists have received significant media coverage over the past year for their astounding efficacy in several indications. Whilst most of the recent fanfare has been related to their role in weight loss, they have been a mainstay of the diabetes treatment landscape for the past two decades. In addition, GLP-1R agonists have recently shown efficacy in reducing heart disease risk and treating certain chronic kidney diseases which has opened the door to potential new indications and label expansions for this drug class in the future. 00:00 Introduction 01:36 About Drug Hunter 03:50 Introduction of Dr. Oliver Philps 09:55 GLP-1 Presentation Start 52:13 Q&A Presented by Oliver Philps, Ph.D. with host Dennis C. Koester, Ph.D. Drug Hunter. Access additional resources and browse previous Flash Talks : https://drughunter.com/flashtalks/ Presented on March 14, 2024

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New evidence brings more good news about the unanticipated effects of the GLP-1 receptor agonists. https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt -- TRANSCRIPT -- Welcome to Impact Factor, your weekly dose of commentary on a new medical study. I’m Dr F. Perry Wilson from the Yale School of Medicine. It’s quite a thing that we live in an era with the biggest blockbuster weight-loss drugs in history, and I can look at you straight-faced and say, yeah, but honestly that’s not the most interesting thing about the GLP-1 receptor agonists such as Ozempic. Beyond their clear utility in weight loss, we have good data that demonstrate the drugs lead to improvements in rates of heart disease, liver disease, and even all-cause mortality, and intriguing reports of strange off-target effects: a reduction in gambling, drinking, drug use, smoking, and compulsive shopping. It’s honestly hard to find an organ system or self-destructive behavior that GLP-1 drugs don’t seem to improve somehow. It’s almost strange. It’s as if the statins came out and everyone was excited about the cholesterol going down, and then we discovered that they reversed hair loss or took three strokes off your golf game. How does one drug do so many things? I think the behavioral changes are the clue. The fact that people may drink or smoke less on these drugs should tell you that something is happening in their brains. And if these drugs are acting on the brain, you might well wonder if they can reduce the risk for brain disease — dementia. And, at least according to a new study, the answer appears to be yes. As the GLP-1 drugs started getting more and more popular, I decided to perform some due diligence and refresh what I had learned in med school about this thing called “glucagon-like peptide.” These drugs bind to the same receptor that GLP does, primarily to cause the pancreas to release more insulin when blood sugar is high. But we have plenty of drugs that stimulate insulin release. And they don’t seem to have all these other weird effects. So, what’s going on? When a drug acts on a specific receptor, it is worth seeing what cells in the body have that receptor, and this is a pretty interesting figure that shows that. You see high expression in the pancreas — no surprise. But next is expression in the heart muscle — interesting, considering these drugs have been shown to reduce the risk for heart disease. Then the salivary glands, and then… the cerebral cortex. The brain. And not just any part of the brain, the thinking part of the brain. A lot happens when these drugs bind to a receptor on a cell. But the brain is a mysterious and important organ. In contrast, the heart is relatively simple, and there are multiple randomized trials that show that GLP-1 drugs, as well as some other drugs for diabetes, such as the SGLT2 inhibitors, pioglitazone, and metformin, reduce the risk for cardiovascular disease in people with diabetes. So, it makes sense to ask whether these drugs would do the same for brain disease. Enter this study, "Cardioprotective Glucose-Lowering Agents and Dementia Risk," from Catriona Reddin and colleagues in JAMA Neurology. It’s an impressive bit of work combining data from 23 different randomized trials of these drugs including more than 150,000 individual people, to determine whether they reduce the risk for dementia. This is the best evidence we have to date for a neuroprotective effect of GLP-1 inhibitors. And this is the only type of study that could give us this evidence. The reason you need to combine so much data to detect a signal is that, to date, no randomized trials of GLP-1 drugs have been designed with dementia as a primary outcome. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/glp-1-drugs-might-cut-dementia-risk-half-2025a10008bs?src=soc_yt

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Apfelessig hat in den letzten Jahren als Hausmittel zur Gewichtsabnahme immer mehr an Popularität gewonnen. Viele Menschen schwören darauf, vor dem Schlafengehen einen Esslöffel Apfelessig zu trinken, um die Fettverbrennung zu fördern und den Stoffwechsel anzukurbeln. Aber wie genau wirkt dieser Trick und gibt es wissenschaftliche Beweise dafür?

Die Wirkung von Apfelessig auf den Stoffwechsel

Apfelessig enthält Essigsäure, die dabei helfen kann, den Blutzuckerspiegel nach einer Mahlzeit zu senken. Dies kann dazu führen, dass der Körper weniger Insulin produziert und somit die Fettverbrennung angekurbelt wird. Darüber hinaus kann Apfelessig auch dabei helfen, das Sättigungsgefühl zu fördern und somit Heißhungerattacken vorzubeugen.

Einige Studien haben gezeigt, dass die Einnahme von Apfelessig tatsächlich zu einer leichten Gewichtsabnahme führen kann, insbesondere in Kombination mit einer gesunden Ernährung und regelmäßiger körperlicher Aktivität. Es ist jedoch wichtig zu beachten, dass die Effekte von Apfelessig auf den Stoffwechsel von Person zu Person unterschiedlich sein können.

Es wird empfohlen, vor dem Schlafengehen einen Esslöffel Apfelessig in einem Glas Wasser zu verdünnen und langsam zu trinken, um mögliche Magenbeschwerden zu vermeiden. Es ist auch wichtig, auf die Qualität des Apfelessigs zu achten und auf Bio-Produkte zurückzugreifen, um die besten Ergebnisse zu erzielen.

Apfelessig als Unterstützung für die Gewichtsabnahme

Neben seiner möglichen Wirkung auf den Stoffwechsel kann Apfelessig auch als Unterstützung für die Gewichtsabnahme dienen, indem er das Gefühl der Sättigung fördert und die Verdauung verbessert. Einige Menschen finden es auch hilfreich, Apfelessig als Teil einer Detox-Kur zu verwenden, um den Körper zu entgiften und überschüssiges Wasser auszuschwemmen.

Es ist jedoch wichtig zu beachten, dass Apfelessig allein nicht als Wundermittel zur Gewichtsabnahme angesehen werden sollte. Eine ausgewogene Ernährung, ausreichend Bewegung und ausreichend Schlaf sind nach wie vor die Eckpfeiler eines gesunden Gewichtsverlusts. Apfelessig kann dabei unterstützend wirken, aber allein nicht für signifikante Veränderungen sorgen.

Es wird empfohlen, mit einem Arzt oder Ernährungsberater zu sprechen, bevor man mit der Einnahme von Apfelessig zur Gewichtsabnahme beginnt, insbesondere wenn man unter gesundheitlichen Problemen leidet oder Medikamente einnimmt. Es ist auch wichtig, mögliche Nebenwirkungen im Auge zu behalten und die Dosierung nicht zu überschreiten.

Tipps zur Einnahme von Apfelessig vor dem Schlafen

Um die bestmöglichen Ergebnisse mit Apfelessig zur Gewichtsabnahme zu erzielen, gibt es einige Tipps, die beachtet werden sollten. Zum einen ist es wichtig, den Apfelessig vor dem Schlafengehen in einem Glas Wasser zu verdünnen, um mögliche Magenreizungen zu vermeiden.

Es wird empfohlen, den Apfelessig langsam zu trinken und nicht sofort ins Bett zu gehen, um Sodbrennen oder andere Beschwerden zu vermeiden. Zudem ist es ratsam, auf die Qualität des Apfelessigs zu achten und auf Bio-Produkte zurückzugreifen, um möglichst reine und unverfälschte Essigsäure zu erhalten.

Es ist auch wichtig, die Einnahme von Apfelessig mit einer ausgewogenen Ernährung und regelmäßiger Bewegung zu kombinieren, um die besten Ergebnisse zu erzielen. Der Schlüssel zur erfolgreichen Gewichtsabnahme liegt letztendlich in einem gesunden Lebensstil, in dem Apfelessig als unterstützende Maßnahme eingesetzt werden kann.

FAQ zu Apfelessig und Gewichtsabnahme

Frage: Kann Apfelessig tatsächlich beim Abnehmen helfen?

Antwort: Es gibt Hinweise darauf, dass Apfelessig den Stoffwechsel anregen und die Fettverbrennung fördern kann, was zu einer leichten Gewichtsabnahme führen kann.

Frage: Gibt es Nebenwirkungen bei der Einnahme von Apfelessig?

Antwort: Mögliche Nebenwirkungen von Apfelessig sind Magenbeschwerden, Sodbrennen oder eine Reizung der Speiseröhre. Es ist wichtig, die Dosierung zu beachten und mögliche Beschwerden im Auge zu behalten.

Frage: Wie sollte man Apfelessig am besten einnehmen, um von den möglichen Vorteilen zu profitieren?

Antwort: Es wird empfohlen, vor dem Schlafengehen einen Esslöffel Apfelessig in einem Glas Wasser zu verdünnen und langsam zu trinken, um mögliche Magenbeschwerden zu vermeiden.

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