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Download "Solution Pharmacy" Mobile App to Get All Uploaded Notes, Model Question Papers, Answer Papers, Online Test and other GPAT Materials - https://play.google.com/store/apps/details?id=co.bolton.nqilv Disclaimer:- This video is for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have watched on this channel. Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired, By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that promote insulin secretion and regulate blood glucose levels. Elevated levels of GLP-1 and GIP consequently results in improved glycemic control.6 In clinical trials, vildagliptin has a relatively low risk of hypoglycemia. Vildagliptin is indicated in the treatment of type II diabetes mellitus in adults. As monotherapy, vildagliptin is indicated in adults inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance. It is also indicated as dual therapy in combination with metformin, a sulphonylurea, or a thiazolidinedione in adults patients with insufficient glycemic control despite maximal tolerated dose of monotherapy. Vildagliptin is indicated in the treatment of type II diabetes mellitus in adults. As monotherapy, vildagliptin is indicated in adults inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to contraindications or intolerance.6 It is also indicated as dual therapy in combination with metformin, a sulphonylurea, or a thiazolidinedione in adults patients with insufficient glycemic control despite maximal tolerated dose of monotherapy. Vildagliptin is also marketed in a combination product with metformin for the treatment of adults with type II diabetes mellitus who inadequately respond to either monotherapy of vildagliptin or metformin. This fixed-dose formulation can be used in combination with a sulphonylurea or insulin (i.e., triple therapy) as an adjunct to diet and exercise in adults who do not achieve adequate glycemic control with monotherapy or dual therapy. Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) are incretin hormones that regulate blood glucose levels and maintain glucose homeostasis. It is estimated that the activity of GLP-1 and GIP contribute more than 70% to the insulin response to an oral glucose challenge. They stimulate insulin secretion in a glucose-dependent manner via G-protein-coupled GIP and GLP-1 receptor signalling. In addition to their effects on insulin secretion, GLP-1 is also involved in promoting islet neogenesis and differentiation, as well as attenuating pancreatic beta-cell apoptosis. Incretin hormones also exert extra-pancreatic effects, such as lipogenesis and myocardial function Get in touch with the solution Pharmacy and Pharmacy Dictionary by just clicking the following links- Mobile App - https://play.google.com/store/apps/details?id=co.bolton.nqilv Facebook Group- https://www.facebook.com/groups/solutionpharamcy The main channel for a detailed Syllabus (Solution- Pharmacy) - https://www.youtube.com/c/SOLUTIONpushpendra E-Mail for official and other work - [email protected] #Pharmacydictionarybypushpendrapatel #Pharmacologyclass
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When it comes to weight loss, many individuals struggle to find the right solution that works for them. One emerging option that has been gaining popularity is semaglutide, a medication originally used to treat type 2 diabetes that has shown promising results for weight loss. Semaglutide works by mimicking a hormone in the body called glucagon-like peptide-1 (GLP-1), which helps regulate insulin and control blood sugar levels. In addition to its effects on blood sugar, semaglutide has also been shown to reduce appetite and promote feelings of fullness, leading to decreased food intake and ultimately weight loss.
User Experiences with Semaglutide for Weight Loss
Many individuals who have tried semaglutide for weight loss have reported positive experiences with the medication. One common theme among users is a reduction in appetite and cravings, making it easier to stick to a healthy eating plan and reduce caloric intake. Some users have also noted an increase in energy levels, which can be beneficial for staying active and maintaining a regular exercise routine. Additionally, many users have seen significant weight loss results within a relatively short period of time, which can be motivating and encouraging for continued progress.
Potential Side Effects of Semaglutide
While many users have had positive experiences with semaglutide for weight loss, it is important to note that like any medication, there can be potential side effects. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are generally mild and tend to improve over time as the body adjusts to the medication. However, in some cases, more serious side effects such as pancreatitis or gallbladder problems can occur. It is important to talk to your healthcare provider before starting semaglutide to discuss the potential risks and benefits.
Effectiveness of Semaglutide for Weight Loss
Studies have shown that semaglutide can be an effective tool for weight loss, with some participants losing up to 15-20% of their body weight over the course of several months. This is particularly significant for individuals who have struggled with obesity and have not had success with other weight loss methods. Semaglutide works by targeting the brain’s appetite control center, making individuals feel more satisfied with smaller portions of food. This can lead to sustainable weight loss over time when combined with healthy eating habits and regular physical activity.
Choosing Semaglutide for Weight Loss
If you are considering trying semaglutide for weight loss, it is important to consult with your healthcare provider to determine if it is the right option for you. Your doctor can assess your individual health needs and goals and provide guidance on how to safely and effectively use semaglutide. It is also important to follow a healthy eating plan and exercise regularly while taking semaglutide to maximize its benefits for weight loss. Remember that weight loss is a journey, and it’s important to be patient and consistent with your efforts.
Final Thoughts on Semaglutide for Weight Loss
In conclusion, semaglutide has shown promise as a weight loss medication for individuals struggling with obesity. Many users have reported positive experiences with reduced appetite, increased energy levels, and significant weight loss results. However, it is important to be aware of potential side effects and to consult with your healthcare provider before starting semaglutide. With the right guidance and support, semaglutide can be a valuable tool in achieving your weight loss goals and improving your overall health and well-being.
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