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For episode #76 of "The Weekly Bioanalysis", Dom and John talk about the popular topic of GLP-1 Analogues - these series of recent blockbuster drugs with multiple applications, as well as some of their bioanalytical challenges. First, the guys go over a little bit of the mechanism of action of GLP-1's, then some of the rules around them and their initial diabetic treatments. They talk about the structures, and a little bit about how they are being used in weight loss (which, of course, is how these drugs have become so popular in mainstream culture now). Finally, they will discuss some of the resulting supply chain issues and even some of the bioanalytical challenges and what the future of these GLP-1 Analogues might be. It's a jam packed show - really an interesting, fascinating topic the guys enjoy discussing. “The Weekly Bioanalysis” is a podcast dedicated to discussing bioanalytical news, tools and services related to the pharmaceutical, biopharmaceutical and biomarker industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Senior Scientific Advisors as they chat over coffee and discuss what they’ve learned about the bioanalytical world the past couple of weeks. “The Weekly Bioanalysis” is brought to you by KCAS Bio. KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.

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ПАННА-КОТТА ЛАЙТ На 3 порции. В одной порции всего 80 ккал! Ингредиенты для сливочного слоя: ◽ Молоко (можно взять обычное молоко, ореховое, кокосовое или сливки) - 400 г.; ◽ Агар-агар - 1 ч.л. без горки; ◽ Подсластитель по вкусу; ◽ Ванильный экстракт по желанию. Ингредиенты для ягодного слоя: ◽ Любимые ягоды - 100 г. (у меня голубика); ◽ Вода - 150 г.; ◽ Агар-агар - 1 ч.л. без горки; ◽ Лимонный сок - 1 ч.л.; ◽ Подсластитель по желанию. Приготовление: 1️⃣ В сотейнике смешать молоко, подсластитель и агар-агар. Довести до кипения, кипятить 30 секунд и снять с огня. 2️⃣ Разлить молоко по креманкам, поместить в холодильник до застывания. 3️⃣ Когда молочный слой застынет - делаем ягодный слой👌🏻 Смешать с помощью блендера ягоды, воду, подсластитель и лимонный сок (часть ягод можно не измельчать и добавить целиком). 4️⃣ Ягодную смесь поставить на огонь, добавить агар-агар. Довести до кипения, кипятить 30 секунд и снять с огня. 5️⃣ Когда ягодная смесь немного остынет, залить вторым слоем к молочной основе, поместить в холодильник до застывания. Приятного ❤️

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In the world of weight loss medications, Tirzepatide and Semaglutide have emerged as two popular options that are garnering attention for their effectiveness. These drugs belong to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and are prescribed to help individuals with obesity or overweight in their weight management journey. Both Tirzepatide and Semaglutide have shown promising results in clinical trials, but the question remains – which one is better for weight loss?

Tirzepatide vs. Semaglutide: A Detailed Comparison

Before we dive into the comparison between Tirzepatide and Semaglutide, it’s essential to understand how these medications work and what sets them apart from each other. Both drugs function by mimicking the action of a naturally occurring hormone called GLP-1, which helps regulate blood sugar levels and appetite. By activating GLP-1 receptors in the brain and gut, Tirzepatide and Semaglutide can help individuals feel full, thereby reducing food intake and promoting weight loss.

Efficacy

When it comes to weight loss efficacy, Semaglutide has been the frontrunner in clinical trials. In a landmark study published in The New England Journal of Medicine, participants taking Semaglutide lost an average of 15% of their body weight over 68 weeks, making it a highly effective option for individuals struggling with obesity. On the other hand, Tirzepatide has also shown significant weight loss results in clinical trials, with some trials reporting weight loss of up to 17% over 72 weeks.

Safety Profile

Both Tirzepatide and Semaglutide are generally well-tolerated by most individuals, but they can have some side effects. Common side effects of these medications include nausea, vomiting, diarrhea, and constipation. However, these side effects are usually mild to moderate in severity and tend to diminish over time as the body adjusts to the medication. It’s essential to consult with a healthcare provider before starting any weight loss medication to determine if it is the right choice for you based on your medical history and current health status.

Cost and Accessibility

One significant factor to consider when comparing Tirzepatide and Semaglutide is cost and accessibility. Semaglutide is currently available in both injectable and oral formulations, making it a versatile option for individuals who prefer different administration routes. However, Semaglutide can be costly, especially if it is not covered by insurance. On the other hand, Tirzepatide is a newer medication that is currently in the pipeline for FDA approval, so its cost and availability may vary depending on the market demand and insurance coverage.

Conclusion

In conclusion, both Tirzepatide and Semaglutide are potent weight loss medications that have shown promising results in clinical trials. While Semaglutide has been the gold standard for weight loss efficacy, Tirzepatide is also a promising option for individuals looking to manage their weight effectively. The choice between Tirzepatide and Semaglutide ultimately depends on individual preferences, medical history, and cost considerations. Consult with a healthcare provider to determine the best option for your weight loss journey.

Overall, Tirzepatide and Semaglutide are both effective weight loss medications with their unique strengths and benefits. Regardless of which medication you choose, it’s essential to combine it with a healthy diet, regular exercise, and lifestyle changes to achieve long-term weight loss success. Remember that weight loss medications are just one part of the equation, and sustainable weight loss requires a holistic approach that addresses both physical and mental well-being.