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Orforglipron also reduced blood sugar levels in participants with type 2 diabetes A significant trial of a daily weight-loss pill has found that it helped people to shed the pounds and reduce their blood sugar levels, making it a contender to join the new wave of drugs that combat obesity and diabetes. People who took a 36mg pill of orforglipron lost an average of 7.3kg (16lbs) over nine months, according to results from a phase 3 clinical trial reported by the drug’s manufacturer, Eli Lilly, on Thursday. The trial, which enrolled 559 obese people with type 2 diabetes from the US, China, India, Japan and Mexico, also found that the daily pill reduced blood sugar levels, in some cases bringing them below the formal threshold for diabetes. Results from the trial have been eagerly awaited by health researchers. Orforglipron is a daily pill version of a GLP-1 agonist, the medication used in blockbuster weight-loss injections such as Ozempic and Wegovy. David Ricks, Eli Lilly’s chief executive, said: “As a convenient once-daily pill, orforglipron may provide a new option and, if approved, could be readily manufactured and launched at scale for use by people around the world.” In a statement accompanying the results, the company said the drug met expectations on safety, tolerability, glucose control and weight loss. While weight-loss jabs have soared in popularity, health officials believe that daily pill versions of the medicine could allow more people to control their weight and blood sugar levels. In Britain, two-thirds of adults are either overweight or living with obesity and more than 5 million people have type 2 diabetes. The 40-week trial showed that taking a daily pill of 3mg, 12mg or 36mg reduced blood sugar by 1.2% to 1.5%. During the same period, participants saw their weight drop by an average of 4.5% on the 3mg pill, 5.8% on the 12mg pill and 7.6% on the 36mg pill. The results will be presented at a meeting of the American Diabetes Association in June before publication in a peer-reviewed journal. The company said it would apply for approval to market the drug for weight management later this year and for type 2 diabetes next year. Naveed Sattar, a professor of cardiometabolic medicine at the University of Glasgow, said: “These are important results. Having new oral agents that lower glucose but also meaningfully lower weight well beyond levels seen with most existing diabetes therapies is critical to future type 2 diabetes care. Of course, one caveat is that we do not know the effects of this newer therapy on cardiovascular outcomes but this will be forthcoming in future trials.” - The Guardian
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Sumatra Slim Belly Tonic Review – Discover the truth about this weight loss tonic. Does it really work? Some people lost up to 35 pounds in 5 weeks with Sumatra Slim Belly Tonic. I was unsure at first. Many weight loss products make big claims. But after checking its ingredients, studies, and real reviews, I saw real benefits. In this review, I’ll explain what’s inside, how it works, and if it’s worth trying. Introduction to Sumatra Slim Belly Tonic Sumatra Slim Belly Tonic is a popular health drink. It helps with weight loss and boosts health. This powder is for adults over 18. It claims to improve metabolism, energy, and digestion. I first saw this product on Shark Tank. That made people curious. It is made in an FDA-registered facility, so it is safe. Always check for such approvals before trying a supplement. From my research and user reviews, this tonic does more than help with weight loss. A friend of mine gained weight from stress. After using this tonic, she had fewer cravings, slept better, and felt more energetic. Ingredients like Valerian Root and Berberine help with this. https://healthyweighthappylife.com/sumatra-slim-belly-tonic-review/
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John Goodman’s weight loss journey is one that has captured the attention of fans and the media alike. The actor, known for his roles in films like The Big Lebowski and TV shows like Roseanne, underwent a stunning transformation, shedding an impressive 200 pounds. Goodman’s weight loss has been the subject of much speculation and admiration, as fans marvel at his dedication and discipline in achieving such a significant change.
The Beginning of John Goodman’s Weight Loss Journey
John Goodman’s weight has fluctuated over the years, with the actor struggling with his size for much of his life. In recent years, however, Goodman made the decision to prioritize his health and make a change. His weight loss journey began with a commitment to exercise and a healthier diet, along with the support of professionals who helped him along the way.
Goodman has been open about his struggles with weight and his past unhealthy habits. He has spoken candidly about his journey to better health, inspiring others who may be facing similar challenges. The actor’s dedication to his fitness goals has been evident in his transformation, as he has worked hard to achieve his weight loss milestones.
As Goodman committed to a new lifestyle focused on wellness, he saw significant changes in his body and overall health. His weight loss journey was not without its challenges, but the actor persevered, staying motivated by the positive impact his transformation was having on his life. Goodman’s journey serves as a powerful reminder of the importance of prioritizing health and making sustainable changes for long-term well-being.
John Goodman’s Weight Loss Success
John Goodman’s weight loss success has been a source of inspiration for many, as the actor’s transformation has been nothing short of remarkable. By losing 200 pounds, Goodman not only improved his physical health but also gained a newfound sense of confidence and vitality. His journey serves as a reminder that with dedication and hard work, significant changes are possible.
Goodman’s weight loss success has also sparked conversations about body positivity and the importance of self-care. The actor’s journey has highlighted the benefits of prioritizing health and wellness, regardless of one’s starting point. Goodman’s transformation serves as a powerful example of how making positive changes can lead to a happier, healthier life.
Throughout his weight loss journey, Goodman has emphasized the importance of finding balance and making sustainable lifestyle changes. His success is a testament to the power of perseverance and self-care, as he continues to prioritize his health and well-being. Goodman’s story is a reminder that it’s never too late to make a change and prioritize your health.
Frequently Asked Questions about John Goodman’s Weight Loss
Q: How much weight did John Goodman lose?
A: John Goodman lost an impressive 200 pounds through a combination of exercise, healthy eating, and professional support.
Q: What inspired John Goodman to start his weight loss journey?
A: Goodman was motivated to prioritize his health and wellness, leading him to make significant changes to his lifestyle and habits.
Q: How has John Goodman’s weight loss impacted his career?
A: Goodman’s weight loss has not only improved his physical health but has also boosted his confidence and overall well-being, positively impacting his career and personal life.
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