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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help.  Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?

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Getting tired of those full-body fat-loss exercises that leave your joints screaming? Some of us get easily discouraged because of jumping routines. As we grow older, it's getting hard for our joints to do some straining workouts and ends up not doing anything at all, which brings more problems in the future. This is why I usually do a low-impact, joint-friendly routine that is both effective for fat loss and good for your joints. This low-impact full-body exercise routine is good for your core and cardio. It keeps your heart pumping making you feel energized throughout the routine. From Lateral Steps to Standing Crunches, each move in this routine is designed to engage every muscle group in your body without stressing your joints. Alternating between targeted movements and restorative stretches, this ensures a complete, effective workout routine. Keep pushing for your goals and stay consistent to bring out the best results. Always choose a good balanced diet so your workout can be as effective as it can be. Good luck and have fun! ❤️💪 _**Don’t forget to share your experience and progress in the comment section. If you want to be notified when I upload a new video, make sure to subscribe to our channel. I upload new videos everyday from Monday to Saturday!_ ========================================== Stay connected on my other social media platforms so you can share your journey with others and stay motivated! *Instagram:* https://www.instagram.com/robertasgym/ *TikTok:* https://www.tiktok.com/@robertasgym *Reddit:* https://www.reddit.com/user/robertasgym/ *Twitter:* https://x.com/robertasgym *Tumblr:* https://www.tumblr.com/blog/robertasgym *Wordpress:* https://robertasgym.com/ Let’s keep the motivation going! 💪 ========================================== *TIMECODES:* 00:00 Introduction 00:10 Lateral Steps 00:48 Rest 01:04 Side Bends 01:51 Rest 02:07 Body Rotations 02:51 Rest 03:07 Torso Twists 03:51 Rest 04:07 Windmill 04:56 Rest 05:12 Step Jacks 05:44 Rest 06:00 Knee Raises 06:29 Rest 06:45 Diagonal Abs Left 07:29 Diagonal Abs Right 08:13 Rest 08:29 Standing Crunch 09:19 Rest 09:35 Waist Pinchers Left 10:16 Waist Pinchers Right 10:58 Rest 11:14 Forward Calf Raises 12:06 Rest 12:22 Side Leg Raise Left 13:15 Side Leg Raise Right 14:07 Rest 14:23 Arm Circles 14:58 Rest 15:14 Lateral Arm Circles 15:45 Rest 16:01 Squat 17:23 Rest 17:39 Bridge 18:45 Rest 19:01 Plank 19:38 Rest 19:54 Plank Reaches 20:28 Rest 20:44 Reverse Crunches 21:22 Rest 21:38 Bird Dog 22:28 Rest 22:44 Side Plank Pulse Left 23:11 Side Plank Pulse Right 23:39 Rest 23:55 Super Mans 24:33 Rest 24:49 Knee Tuck Crunch 25:27 Rest 25:43 Russian Twist 26:07 Rest 26:23 T Plank 27:31 Rest 27:47 Plank Reaches 28:21 Rest 28:37 Plank Slaps 29:03 Rest 29:19 Thigh Stretch Left 30:09 Rest 30:25 Thigh Stretch Right

Navigating The Weight Loss Medication Landscape Semaglutide Tirzepatide And Retatrutide Explained

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