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In this Janette’s “Tips ‘N’ Sips”, Janette discusses the pluses and minuses of losing weight on Ozempic.

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Are weight loss drugs like Ozempic really the only option to reach your dream body? In today’s episode, I’m joined by Dr. Edward Walker from Calocurb as he breaka down this revolutionary, natural, science-backed alternative that supports GLP-1 production minus the pharmaceutical side-effects. Together, we unpack how amarasate, a New Zealand hops extract, regulates appetite, curb cravings, & promote sustainable weight management. Learn the science behind its effects, dosing strategies, and how it can fit into your bioharmonized approach to health in this episode on “The Better GLP-1 Alternative”. 📕 Video chapters 0:00 Introduction 6:05 How Dr. Walker got started with Amarasate 7:03 How these appetite suppressants work & their downsides 10:29 What GLP-1 & injectable peptides actually do 12:15 How the pharmaceutical industry stabilized GLP-1 13:18 Why GLP-1 isn’t bioidentical 14:50 Other effects of GLP-1 on the brain & vagus nerve 16:52 What happens with your insulin levels 20:57 The biggest concern about taking GLP-1 24:15 Different generations of GLP peptides 29:33 What is Amarasate & how it differs from GLP-1 34:53 Uses of Amarasate & its major effects 37:20 Do people build tolerance to Amarasate over time? 41:25 What does Amarasate taste like & how to dose it 48:23 Mastoid’s impact on the brain 50:32 How different people respond to the peptide 53:21 Other protocols to stack with Amarasate 56:33 Diet requirements for optimal results 1:01:17 Safety considerations before taking Amarasate 1:10:21 Outro 📝 Frequently updated articles: Top Peptides For Major Fat Loss https://outliyr.com/peptides-for-weight-loss Natural Semaglutide Alternatives For Powerful Weight Loss (Safe & Effective GLP-1 Activators) https://outliyr.com/best-natural-glp1-semaglutide-alternatives Dangers of GLP-1 Weight Loss Drugs https://outliyr.com/dangers-glp1-weight-loss-drugs-semaglutide-liraglutide 🛒 Click the link below and use code URBAN to save 10%: https://outliyr.com/calocurb 🎤 Get weekly insider secrets from world-class experts: https://www.youtube.com/@mindbodypeakperformance?sub_confirmation=1 🔔 Subscribe for more free "biohacking" Human Performance tips, product reviews, and the latest info: https://www.youtube.com/@outliyr?sub_confirmation=1 🚀 Tools, products, & services I recommend: https://outliyr.com/shop 🔥 Join my VIP club - It's a weekly newsletter sharing Human Performance tips, biohacking news, freebies, and more! https://outliyr.com/vip 📝 About our guest Dr. Edward Walker is a scientist & lecturer specializing in plant-based nutraceuticals for health & wellness. He earned his PhD from the University of Auckland, researching the antioxidant effects of berry fruits, & now works at The New Zealand Institute for Plant & Food Research, focusing on clinical validation of nutraceutical products. As a guest lecturer at the University of Auckland, he teaches about nutraceuticals & functional foods. His 13-year research on plant-based appetite suppressants led to the development of Amarasate®, a NZ hops-based suppressant with a mode of action similar to GLP-1 anti-obesity drugs. Passionate about evidence-based nutraceuticals, he believes they can enhance health & help prevent chronic disease. 🔑 Key takeaways - Amarasate is a plant extract that naturally stimulates GLP-1 without pharmaceutical risks - Semaglutide’s half-life is significantly longer than natural GLP-1, lasting up to a week instead of 2 minutes - The best approach is to start with a low dose & gradually increase it - The optimal dose of amarasate varies for individuals due to differences in gut response - Synthetic GLP-1 drugs can cause the body to downregulate its natural GLP-1 production 🔗 Links - Full episode show notes: https://mindbodypeak.com/193 - Music by Luke Hall: soundcloud.com/c_luke_hall 🙏 Support the show - Subscribe: https://mindbodypeak.com/subscribe - Leave an Apple Podcast review: https://mindbodypeak.com/rate-podcast Do you have questions, thoughts or feedback? Let me know in the comments below and one of us will get back to you! Disclaimers: Nothing posted on this channel is medical advice or a substitute for advice from your physician or healthcare provider. Always contact your healthcare professional with any questions about a medical condition or your personal health. Additionally, some of the links provided above are affiliate links. They don't cost you anything, but I make a tiny commission from the sale. Honesty is key on my channel, and thank you for your support! You may read the full disclaimer here: https://outliyr.com/disclaimers

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Be sure to Subscribe for 3x Videos per Week! http://www.ThomasDeLauer.com How Does it Work? Fat Burning Hormone: Leptin & Cheat Meal Science: Thomas DeLauer Leptin is actually a hormone – meaning that once it is released it will travel to another area of your body to make things happen Once leptin is released from your fat it enters your blood and travels up to your brain, delivering a message as to how much fat (fuel) you have on hand *The hypothalamus in the brain is what controls leptin. The hypothalamus is comprised of an elaborate system of leptin receptors* When your brain answers the leptin, it tells you how fast you can run your metabolism based on how much gas is in your gas tank Your brain has no way to see how much stored fat you have on hand, it relies on the leptin to determine your state of overall nutrition and fuel reserves If the leptin signals that it’s low, it means eat more. When you’ve eaten enough, leptin levels rise, and the leptin in your brain now says you’re full – resulting in a full signal Simply put, it lets your brain know how much fat is in your body. As leptin levels rise, your appetite diminishes. As leptin levels fall, your appetite increases (1) Leptin and Metabolism Once you do get a leptin-related full signal then permission is given for your body’s metabolism to get in gear and go When leptin levels are adequate your metabolism begins to run faster When leptin levels are too low your brain thinks there is a famine and your metabolic rate is set to hibernation mode – metabolism slows down Simply put, it regulates the rate of fat breakdown. As leptin levels rise, your metabolic rate increases. As leptin levels fall, your metabolism slows (1,2) Leptin Resistance The body doesn’t always listen to the leptin message and leptin resistance occurs The leptin signal isn’t being heard, so it cannot stimulate your metabolism or suppress your appetite Because fat cells produce leptin in proportion to their size, obese people have very high levels of leptin Given the way leptin is supposed to work, these people’s brains should realize they have a sufficient amount of fat The problem is that the leptin signal isn’t working. There’s excess leptin floating around that the brain doesn’t see When the brain doesn’t receive the leptin signal, it thinks that the body is starving, even though it has more than enough energy stored Causes the brain to think that we need to eat more and conserve energy – makes us overeat and feel lazy (2,3) Physical activity and enough sleep may help to reverse leptin resistance Having high blood triglycerides can prevent the transport of leptin from blood and into the brain - the best way to lower triglycerides is to reduce carbohydrate intake Bottom line: what we consider necessary for good health and weight loss is what’s necessary to keep leptin levels in check A re-feed day is a day where you increase your calories up to maintenance calories or slightly above by increasing your carbohydrate intake The purpose of a re-feed day is to help boost your metabolism and help restore your Leptin levels - way of telling your body that you aren’t starving, and that there’s food available Leptin is highly responsive to glucose metabolism So when doing a re-feed, you will benefit much more if the majority of your additional calories are coming from good sources of carbohydrates that will turn into glucose (potatoes, pasta, rice, bread, oats and grains) When done this way, leptin levels will show a significant rise over if you had eaten a surplus of calories coming from more protein, fat, or fructose More simply, by having a re-feed day you will spike your leptin levels back up and kick start your metabolism to burn more fat – 1 step back, 2 steps forward (4) References 1) What is Leptin? | Health & Wellness News. (n.d.). Retrieved from http://www.wellnessresources.com/weight/articles/what_is_leptin/ 2)Leptin: How to Make This Fat-Burning Hormone Work for You | HuffPost. (n.d.). Retrieved from http://www.huffingtonpost.com/leo-galland-md/leptin-how-to-make-this-fat-burning_b_806529.html 3) Leptin and Leptin Resistance: Everything You Need to Know. (n.d.). Retrieved from https://authoritynutrition.com/leptin-101/ 4) Science of Leptin and Re-feed Days | George Heatlh. (n.d.). Retrieved from http://www.georgehealth.com/science-of-leptin-and-re-feed-days/ 5) Clinical Review: Regulation of Food Intake, Energy Balance, and Body Fat Mass: Implications for the Pathogenesis and Treatment of Obesity. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319208/ 6) Obesity is associated with hypothalamic injury in rodents and humans. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248304/

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💡 Will GLP-1 Prices Finally Drop? Here’s What You Need to Know! 💡 GLP-1 drugs like Ozempic, Wegovy, and Zepbound have transformed diabetes and weight management — but their high costs keep them out of reach for many. The good news? Prices might be dropping soon! In this video, we’ll explore how government actions, new generic options, direct-to-consumer sales, and fierce market competition could finally make GLP-1 medications more affordable. 🌐 From government price controls to new medications in development, we’ve got all the details you need to know. 👉 Comment below: When do YOU think GLP-1 prices will finally come down? What do you think the price should be?

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