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In this episode of The Health Movement Podcast, Derek and guest Brooke Brum dive into the nuances of building muscle and losing fat, particularly as they relate to common New Year’s resolutions. They explore the importance of understanding body composition over scale weight, the long-term commitment required for fitness success, and how to keep workouts engaging by introducing variety. Brooke shares her expertise on shifting focus from aesthetics to performance-based goals, the critical role of education in youth fitness, and adopting a holistic approach to health that considers sleep, nutrition, and mental well-being. Together, they discuss practical strategies for meal prep, the benefits and risks of CrossFit, injury management, and creating sustainable fitness routines. Takeaways Scale weight is not a true reflection of body composition, which includes muscle mass and bone density. Long-term fitness is a lifestyle change, not a quick fix. Incorporating both strength training and cardiovascular fitness is essential for building muscle. Variety in workouts prevents plateaus, reduces injury risk, and keeps routines engaging. Meal prep can simplify nutrition and support fitness goals. High-intensity workouts like CrossFit can be effective if performed with proper guidance. Holistic health includes addressing cortisol levels, sleep, and mental health. Social interaction in fitness can boost motivation and mental well-being. You can find Brooke on Instagram here (https://www.instagram.com/fit.4lyfe_/) or at www.fit4lyfe.net Join our newsletter here: https://the-health-movement-podcast.kit.com/421fb99eb5 Tim @tharrold17 and Derek @derek.josephs can both be found on Instagram.
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Key Points Question Are glucagon-like peptide-1 receptor agonists semaglutide and liraglutide, which were originally introduced for the treatment of type 2 diabetes and are frequently prescribed due to their weight loss properties, associated with disproportionately increased reporting of suicidality? Findings This disproportionality analysis through the case-control design based on the World Health Organization global database collecting suspected adverse drug reactions, identified a disproportionality signal of suicidal ideation with semaglutide, which remained significant when comparing semaglutide with dapagliflozin and metformin and in the subgroup of patients with coreported use of antidepressants and benzodiazepines. Meaning A detected signal of semaglutide-associated suicidal ideation warrants urgent clarification. Abstract Importance Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have gained use primarily due to their weight-reduction effects, although a regulatory review was undertaken for potential suicidality concern. Objectives To evaluate potential signals for suicidal and self-injurious adverse drug reactions (ADRs) associated with the GLP-1 RAs semaglutide and liraglutide. Design, Setting, and Participants Disproportionality analysis through the case-control design using the World Health Organization (WHO) global database of suspected ADRs. Participants were clinical patients worldwide experiencing an ADR suspectedly attributable to semaglutide or liraglutide in the database from inception to August 30, 2023. Data were analyzed from September to December 2023. Exposure Treatment with semaglutide or liraglutide regardless of indication or treatment duration. Main Outcomes and Measures Reporting odds ratio (ROR) and the bayesian information component (IC) with 95% CIs were calculated as measures of disproportionate reporting of suicidal and self-injurious ADRs associated with semaglutide and liraglutide compared with all other medications. Sensitivity analyses were conducted including patients with coreported use of antidepressants and benzodiazepines and using dapagliflozin, metformin, and orlistat as comparators. A disproportionality signal was considered when the lower limits of the ROR and IC were above 1 and 0, respectively. Results A total of 107 (median [IQR] age 48 [40-56] years; 59 female patients [55%]) and 162 (median [IQR] age 47 [38-60] years; 100 female patients [61%]) cases of suicidal and/or self-injurious ADRs were reported between November 2000 and August 2023 with semaglutide and liraglutide, respectively. Significant disproportionality was detected only for semaglutide-associated suicidal ideation (ROR, 1.45; 95% CI, 1.18-1.77; IC, 0.53; 95% CI, 0.19-0.78), which remained significant in patients with coreported use of antidepressants (ROR, 4.45; 95% CI, 2.52-7.86; IC, 1.96; 95% CI, 0.98-2.63) and benzodiazepines (ROR, 4.07; 95% CI, 1.69-9.82; IC, 1.67; 95% CI, 0.11-2.65), when compared with dapagliflozin (ROR, 5.56; 95% CI, 3.23-9.60; IC, 0.70; 95% CI, 0.36-0.95), metformin (ROR, 3.86; 95% CI, 2.91-5.12; IC, 1.20; 95% CI, 0.94-1.53) and orlistat (ROR, 4.24; 95% CI, 2.69-6.69; IC, 0.70; 95% CI, 0.36-0.95). Conclusions and Relevance This study using the WHO database found a signal of semaglutide-associated suicidal ideation, which warrants urgent clarification.
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In today's episode I am diving in to two of the most misunderstood hormones and how they influence your body. I will also be giving you some tips on how to know if your insulin and/or cortisol levels are off and how to better balance them. Ways to work with me: https://myfitbodyrx.com/programs Join my free nutrition group : https://www.facebook.com/share/g/19ZEfSgcfX/ Follow me on IG: https://www.instagram.com/cherylnasso
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Enjoy these easy, 10-minute healthy lunch ideas to support your health and weight loss goals! All easy recipes that are packed with protein. Thanks to LMNT for sponsoring this video. Visit http://DrinkLMNT.com/DANISPIES to get a free sample pack with any purchase! 👉🏻 Sign up for my emails (& never miss a recipe!): https://cleananddelicious.ck.page/weeklynewsletter 📚 Order my Clean & Delicious Cookbook: https://amzn.to/3oxfBMS ☀️ Grab my FREE 3-part, mind-body weight loss video training: https://thedontdiet.com 🎤 Healthy Lunch Recipes Mentioned: Buffalo Chicken Salad: https://cleananddelicious.com/buffalo-chicken-lettuce-cups/ Tuna Egg Salad Recipe: https://cleananddelicious.com/quick-tuna-salad-w-chopped-egg-27g-protein/ 🍲 Favorite Foods & Kitchen Tools: Sprouted Bread: https://amzn.to/490HmyV Amys Lentil Veggie Soup: https://amzn.to/4lcIBCb My Kitchen Knife: https://amzn.to/3MVREVT Favorite Sea Salt: https://amzn.to/3Qr6Mzt Glass Storage Containers: https://amzn.to/3rqwWZq 💛 Let's Connect: Website: https://cleananddelicious.com/ Instagram: https://www.instagram.com/clean_and_delicious/ Facebook: https://www.facebook.com/CleanAndDeliciousWithDaniSpies/ Pinterest: https://www.pinterest.com/danispies/ Twitter: https://twitter.com/DaniSpies TIMESTAMPS 0:00 Intro 0:35 Lunch idea one 2:44 Lunch idea two 6:03 Sponsor Break 8:13 Lunch idea three 11:09 Lunch idea four 13:43 Outro Disclaimer: product links may include affiliate links. #easybreakfastrecipes #healthybreakfastideas #highproteinbreakfast #weightlossrecipe
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