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Learn more about becoming an Insider: https://www.benbikman.com Dr. Bikman’s Metabolic Classroom lecture this week explores the physiological role and implications of GLP-1 (glucagon-like peptide-1) and the GLP-1 receptor agonist drugs used for type 2 diabetes management and weight loss. Ben begins by explaining GLP-1 as a hormone produced in the intestines in response to food. It plays a vital role in slowing gastric emptying, suppressing glucagon, and regulating appetite by signaling fullness to the brain. These mechanisms contribute to its effects on stabilizing blood sugar and enhancing insulin sensitivity. He then delves into GLP-1 receptor agonists, drugs that mimic GLP-1’s actions, including semaglutide, liraglutide, and others marketed under brand names like Ozempic and Wegovy. These medications have gained fame for their weight loss efficacy, often leading to reductions in body weight by 15% or more. However, Ben emphasizes that weight loss involves not only fat but also lean mass, raising concerns about muscle loss and metabolic health. Additionally, he discusses the medications’ side effects, including depression, anhedonia, and potential long-term complications like fat cell development and gallstones. The lecture also addresses the diminishing returns of these drugs over time, noting that their efficacy in reducing cravings and improving eating control tends to wane after prolonged use. Dr. Bikman highlights that education on healthy eating and resistance training is crucial for maintaining health outcomes, as reliance solely on medication can lead to unintended consequences, such as increased fat regain after discontinuation. Ben concludes by stressing the importance of combining these drugs with a low-carb diet and resistance training to minimize muscle loss and optimize long-term outcomes. He encourages using the lowest effective dose and underscores the need for lifestyle changes to complement pharmacological interventions. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #GLP1 #WeightLossDrugs #Ozempic #Wegovy #Semaglutide #Liraglutide #Type2Diabetes #DiabetesManagement #InsulinResistance #WeightLossTips #MetabolicHealth #DrBenBikman #MetabolicScience #MuscleHealth #MentalHealthMatters #LowCarbDiet #FatLoss #HealthRisks #DiabetesDrugs #ScienceExplained Timestamps: 00:01 - Introduction and Overview 02:16 - What is GLP-1? 03:15 - GLP-1's Role in Metabolism 05:08 - Appetite Regulation and Insulin Effects 07:05 - GLP-1 and Blood Sugar Management 08:10 - Introduction to GLP-1 Receptor Agonists 09:05 - Key GLP-1 Drugs and Brand Names 12:04 - Weight Loss Mechanisms of GLP-1 Drugs 14:06 - Mental Health Risks of GLP-1 Drugs 16:15 - Muscle Loss Concerns 18:24 - Fat Cell Differentiation and Regain Risk 20:07 - Long-Term Diminishing Effects 25:30 - Pancreatitis and Gallstones 29:11 - Closing Thoughts and Recommendations Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: Ben10) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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Maintaining a trim midsection does more than make you look great—it can help you live longer. Larger waistlines are linked to a higher risk of heart disease, diabetes and even cancer. Losing weight, especially belly fat, also improves blood vessel functioning and also improves sleep quality. It’s impossible to target belly fat specifically when you diet. But losing weight overall will help shrink your waistline; more importantly, it will help reduce the dangerous layer of visceral fat, a type of fat within the abdominal cavity that you can’t see but that heightens health risks Here’s how to whittle down where it matters most. Try curbing carbs instead of fats. When Johns Hopkins researchers compared the effects on the heart of losing weight through a low-carbohydrate diet versus a low-fat diet for six months—each containing the same amount of calories—those on a low-carb diet lost an average of 10 pounds more than those on a low-fat diet—28.9 pounds versus 18.7 pounds. An extra benefit of the low-carb diet is that it produced a higher quality of weight loss, Stewart says. With weight loss, fat is reduced, but there is also often a loss of lean tissue (muscle), which is not desirable. On both diets, there was a loss of about 2 to 3 pounds of good lean tissue along with the fat, which means that the fat loss percentage was much higher on the low-carb diet. Think eating plan, not diet. Ultimately, you need to pick a healthy eating plan you can stick to, Stewart says. The benefit of a low-carb approach is that it simply involves learning better food choices—no calorie-counting is necessary. In general, a low-carb way of eating shifts your intake away from problem foods—those high in carbs and sugar and without much fiber, like bread, bagels and sodas—and toward high-fiber or high-protein choices, like vegetables, beans and healthy meats. Keep moving. Physical activity helps burn abdominal fat. “One of the biggest benefits of exercise is that you get a lot of bang for your buck on body composition,” Stewart says. Exercise seems to work off belly fat in particular because it reduces circulating levels of insulin —which would otherwise signal the body to hang on to fat—and causes the liver to use up fatty acids, especially those nearby visceral fat deposits, he says. The amount of exercise you need for weight loss depends on your goals. For most people, this can mean 30 to 60 minutes of moderate to vigorous exercise nearly every day. Lift weights. Adding even moderate strength training to aerobic exercise helps build lean muscle mass, which causes you to burn more calories throughout the entire day, both at rest and during exercise. Become a label reader. Compare and contrast brands. Some yogurts, for example, boast that they’re low in fat, but they’re higher in carbs and added sugars than others, Stewart says. Foods like gravy, mayonnaise, sauces and salad dressings often contain high amounts of fat and lots of calories. Belly fat is the visceral fat surrounding the liver and other organs in the abdomen, close to the portal vein that carries blood to the liver. This fat can be harmful to the body but proper measures can be taken to reduce belly fat. That said, spot reduction is not a practice that is recommended by HealthifyMe. However, we look at what one can do to reduce belly fat. Table of Contents: Causes of Belly Fat Tips to Reduce Belly Fat Exercises to Reduce Belly Fat Fat Loss Diet Plan The Dangers of Belly Fat Accumulation Causes of Belly Fat Contrary to popular belief, people with a normal body mass index(BMI), but having excess belly fat, also face increased risk of the above health problems. Here are a few potential reasons for the accumulation of excessive belly fat: Sugary food and beverages: Studies have shown a link between high sugar intake and excess belly fat. This is mainly due to the extra refined sugar added during processing. While excess sugar in any form can be harmful, sugar-sweetened beverages are especially problematic. Alcohol: Another possible cause for sudden belly fat gain is alcohol. Studies have linked the excessive consumption of alcohol to an increase in belly fat, with one study finding that men who consumed more than 3 drinks a day were 80% more likely to have excess body fat. Sedentary lifestyle: One’s activity levels also play a major role in the accumulation of belly fat. A study showed that people who performed resistance training or aerobic exercise for a year after losing weight were able to prevent abdominal fat gain, while those who did not exercise faced a 25-38% increase in belly fat. Stress: Cortisol, commonly called the ‘stress hormone’, is produced by the adrenal glands in stressful situations. While stress drives overeating, cortisol causes the excess calories to be stored as fat in the belly.

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Beetroot salad healthy diet recipe 😋 Video Credits-Miss Wow Tamizhaa. GENERAL DISCLAIMER: This Channel DOES NOT Promote or encourage Any illegal activities, all contents provided by This Channel. CONTENT DISCLAIMER: All the information shared here cannot be said to be completely true and thus the solution is guaranteed. However, it is given selectively based on experiences. We would never claim that this is the be-all and end-all. Hence, the best option is to consult a doctor for chronic or serious problems. Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair #mrshomefood #food #trending #homefood #recipe #mrshomefoodlifestyle #cookingchannel #healthydreakfast #beetroot #beetrootsalad #diet #dietrecipe #food #misswowtamizhaa Connect with us on social media: 📸 Instagram: https://www.instagram.com/mrshomefood/ 🐦 Facebook: https://www.facebook.com/profile.php?id=61550508950806 0 https://www.instagram.com/mrshomefood/ 🐦 Facebook: https://www.facebook.com/profile.php?id=61550508950806

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Semaglutide is a medication that has been gaining attention for its potential to aid in weight loss in individuals who are not diabetic. Originally developed as a treatment for type 2 diabetes, semaglutide has shown promising results in clinical trials for weight management in non-diabetic patients. Understanding how semaglutide works for weight loss in non-diabetics involves exploring the mechanisms by which this medication affects the body’s metabolism and appetite control.

Mechanisms of Action

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These medications work by mimicking the effects of GLP-1, a hormone produced naturally in the body that regulates blood sugar levels and food intake. When semaglutide is injected, it activates GLP-1 receptors in the brain and throughout the body, leading to a variety of physiological changes that can contribute to weight loss.

One of the key mechanisms by which semaglutide promotes weight loss is by slowing down the emptying of the stomach. This delay in gastric emptying can help individuals feel fuller for longer periods after eating, leading to reduced calorie intake over time. In addition, semaglutide has been shown to reduce hunger cravings and increase feelings of satiety, further supporting its ability to aid in weight management.

Another important aspect of semaglutide’s mechanism of action is its effects on energy expenditure. Studies have indicated that individuals taking semaglutide may experience an increase in resting metabolic rate, meaning that they burn more calories even when at rest. This can contribute to greater overall weight loss when combined with a balanced diet and regular physical activity.

Benefits of Semaglutide for Weight Loss

The potential benefits of using semaglutide for weight loss extend beyond its effects on appetite and metabolism. Clinical trials have demonstrated that individuals taking semaglutide may experience significant reductions in body weight compared to a control group receiving a placebo. In some cases, weight loss of 10% or more of initial body weight has been reported, representing a substantial improvement in overall health and well-being.

In addition to promoting weight loss, semaglutide has been associated with improvements in cardiovascular risk factors such as blood pressure, cholesterol levels, and blood sugar control. These benefits are particularly relevant for individuals who are overweight or obese, as they are more likely to develop conditions such as heart disease, diabetes, and stroke. By addressing both weight management and cardiovascular health, semaglutide has the potential to reduce the risk of future chronic diseases.

Furthermore, semaglutide has been well-tolerated in clinical trials, with relatively few side effects reported. Common side effects may include nausea, vomiting, and diarrhea, especially when first starting the medication. However, these symptoms typically subside over time as the body adjusts to the medication. Overall, the safety profile of semaglutide for weight loss appears favorable compared to other weight management strategies.

Considerations for Use

Before considering treatment with semaglutide for weight loss, individuals should consult with a healthcare provider to determine if this medication is appropriate for their unique needs. Semaglutide is typically prescribed for individuals who have a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity such as hypertension or dyslipidemia. Healthcare providers will evaluate the potential risks and benefits of semaglutide in each individual case.

It is important to note that semaglutide is not a standalone solution for weight loss and should be used in conjunction with a comprehensive approach that includes a healthy diet, regular physical activity, and behavior modifications. Individuals taking semaglutide should work closely with their healthcare provider to establish realistic goals and monitor their progress over time. By combining semaglutide with lifestyle changes, individuals can maximize the benefits of this medication for long-term weight management.

In conclusion, semaglutide offers a promising option for individuals seeking effective and sustainable weight loss solutions. By understanding the mechanisms of action and potential benefits of semaglutide, non-diabetic patients can make informed decisions about incorporating this medication into their weight management plans. With careful consideration and guidance from healthcare providers, semaglutide has the potential to significantly impact the lives of individuals struggling with obesity and its associated health risks.

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I’ve lost 28 inches around my belly since starting Mounjaro 7 months ago. That’s over 2 feet 👀 my belly sat on top on my thighs and weighed so much that I rarely had back pain just from daily living. I’m so thankful for my doctor who knew how life changing this would be for me and all of the changes starting this medication has inspired . 💕

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