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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help. Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?
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Oceaura GLP-1 Patches Review – Does It Work Or A Scam? Oceaura GLP-1 Patches claim to offer prescription-level weight loss—without injections or pills. But are they legit, or just viral hype? Marketed as a skin patch alternative to GLP-1 medications like tirzepatide, Oceaura says their “Tirasipetide™” formula curbs appetite, boosts metabolism, and balances blood sugar. Sounds like science—but the truth is far more concerning. In this review, I uncover: 🚫 No real GLP-1 ingredients—just herbal extracts 🔬 Zero clinical trials, patents, or scientific backing 🧑⚕️ Fake “Dr. Jonathan Kim” endorsement (AI-generated image) ⚠️ Misleading delivery claims with no documentation 🤖 AI-generated customer reviews and photos The site uses high-tech buzzwords and flashy design, but offers no evidence, no transparency, and no reason to trust what’s in the patch. This isn't medicine—it’s marketing. 👇 Seen the patch or tried it? Drop your experience in the comments. 👍 Like, subscribe, and turn on notifications for more honest, in-depth reviews. Keywords: oceaura glp 1 patches reviews, oceaura glp-1 patches, oceaura glp-1 patches scam, oceaura glp-1 patches legit, is oceaura glp-1 patches scam, oceaura glp-1 patches review, oceaura glp-1 patches reviews, is oceaura glp-1 patches legit, oceaura glp-1 patches legit reddit, oceaura glp-1 patch, glp 1 patches scam, glp 1 patches fake, glp 1 patches review, oceaura glp 1 reviews, glp 1 patches reviews, oceaura glp-1 patch review, glp 1 patches honest review, glp 1 weight loss patches, kind patches glp 1 reviews #OceauraGlp-1Patches #OceauraGlp-1Patchesscam #OceauraGlp-1Patchesreview #OceauraGlp-1Patches #gentleglp-1patches #oceauraglp-1 #oceauraglp-1 #honestcheck Copyright Disclaimer: This video is for educational and informational purposes only. All opinions expressed are based on research and customer reports. Under Section 107 of the Copyright Act 1976, fair use is permitted for criticism, comment, news reporting, teaching, scholarship, and research.
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🔥 The Over-40 Muscle Trap: Why Losing Weight the Wrong Way Makes You Weaker 🔥 🚨 Attention if you’re over 40 and trying to lose weight… You might be falling into a dangerous trap. It’s not just about fat loss—it’s about what you’re losing with it. And if you sacrifice muscle mass, your metabolism, strength, and independence pay the price. 💡 Here’s the truth most diets won’t tell you: Up to 25% of "weight loss" on a typical diet comes from muscle, not fat (unless you do this right). After 40, your body loses 3–8% muscle per decade—and it speeds up after 60. Muscle burns 3x more calories than fat—lose it, and your metabolism slows to a crawl. 💪 The Solution? Body Recomposition—Not Just Weight Loss You need 3 muscle-preserving pillars to lose fat the smart way: 1️⃣ High-Protein Diet (1.6–2.2g per kg of body weight) 2️⃣ Resistance Training (Lift, push, pull—cardio alone won’t cut it!) 3️⃣ Smart Calorie Deficit (Too aggressive = muscle meltdown) 📉 Why Most Diets Fail After 40 Low-protein diets + excessive cardio + extreme calorie cuts = a recipe for muscle loss, weakness, and rebound weight gain. ✅ Your Game Plan: Eat like a builder (chicken, eggs, salmon, Greek yogurt) Train like an athlete (squats, rows, presses—2–4x/week) Recover like a pro (sleep 7–9 hours, hydrate, cycle calories) 🔬 Backed by Science: A study in Obesity found 25% of weight loss was muscle without proper training & protein. Research in The American Journal of Clinical Nutrition showed high-protein diets DOUBLE fat loss while preserving muscle. 🌟 The Real Flex After 40? Staying strong, mobile, and metabolically sharp—not just skinny. 📢 Share this with anyone over 40 who’s tired of losing weight the wrong way! 💬 Comment “MUSCLE” if you’re ready to fight sarcopenia! 👍 Like & Save to keep these tips handy. #Over40Fitness #MuscleAfter40 #SmartFatLoss How To Lose Fat and Keep Muscle After 40 (Let’s redefine aging—one rep at a time. 💪)
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When it comes to weight loss, there are countless options available in the market, including diet plans, exercise routines, and weight loss pills. Among these, FDA approved weight loss pills have gained popularity as they are perceived to be safe and effective. However, it is essential to understand the safety and effectiveness of these pills before incorporating them into your weight loss journey.
Understanding the Safety of FDA Approved Weight Loss Pills
Before a weight loss pill can be approved by the Food and Drug Administration (FDA), it undergoes rigorous testing to ensure its safety. These tests evaluate the potential side effects of the pill and how it interacts with other medications. Additionally, the FDA monitors the pill’s safety after it hits the market, taking action if any concerning reports surface. This stringent process provides a level of assurance regarding the safety of FDA approved weight loss pills.
It is essential to remember that while FDA approved weight loss pills are deemed safe for consumption, they may still have side effects. Common side effects include nausea, constipation, headaches, and dizziness. It is crucial to consult with a healthcare professional before starting any weight loss pill to understand potential risks and ensure it is the right choice for you.
Furthermore, it is crucial to follow the recommended dosage and usage instructions provided with the weight loss pill. Taking more than the recommended amount can lead to adverse effects and negate any potential benefits. Additionally, combining multiple weight loss pills or using them alongside other medications without consulting a doctor can be dangerous.
Evaluating the Effectiveness of FDA Approved Weight Loss Pills
While FDA approved weight loss pills are considered safe, their effectiveness varies from person to person. It is essential to manage expectations and understand that these pills are not a magic solution for weight loss. They are designed to complement a healthy diet and regular exercise routine, enhancing your efforts rather than replacing them entirely.
When evaluating the effectiveness of a weight loss pill, look for scientific studies and clinical trials that support its claims. These studies provide insight into how the pill works, its impact on weight loss, and any potential benefits. Additionally, real-life testimonials from users can offer a perspective on the pill’s effectiveness beyond the data presented in studies.
It is important to approach FDA approved weight loss pills with a realistic mindset and be wary of products that promise drastic results with minimal effort. Sustainable weight loss requires commitment, dedication, and a holistic approach that includes not only the use of weight loss pills but also healthy lifestyle choices.
Navigating the World of FDA Approved Weight Loss Pills
With numerous FDA approved weight loss pills available in the market, it can be overwhelming to choose the right one for your needs. To make an informed decision, research different pills, their ingredients, and potential side effects. Consult with a healthcare professional to discuss your weight loss goals and determine the most suitable option for you.
When selecting a weight loss pill, consider factors such as your current health status, medical history, and any existing conditions. Certain weight loss pills may be contraindicated for individuals with specific health issues or medications. It is crucial to disclose all relevant information to your healthcare provider to ensure a safe and effective weight loss journey.
Remember that FDA approved weight loss pills are just one tool in your weight loss arsenal. Alongside the use of these pills, focus on maintaining a balanced diet, staying active, and practicing healthy habits that support your overall well-being. By combining these efforts, you can increase the likelihood of achieving sustainable weight loss results.
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The biggest obstacle to weight loss success is dealing with sabotage from friends and family. People don't like it when you change. The ways they used to manipulate you stop working. Stop your friends and family from sabotaging your weight loss success and have them peeing in their pants after they see how much weight you've lost. I lost 100 pounds in 100 days using this technique to prevent my friends and family from sabotaging me. Please let me know what you think, leave your comments below. You can do it, Richard If you have any questions, email me at [email protected] check out my website: http://www.100pounds100days.com
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Many women with PCOS have excess weight that is concentrated more around the abdominal region which can seem hard to get rid of. This is because of insulin resistance where the body is not able to utilize glucose effectively and have high levels of insulin in the body. Following a healthy lifestyle that is sustainable can help you maintain and lose weight in the long-term. Along with following balanced nutrition, regular exercise in the form of cardio and strength can help improve insulin sensitivity and hence aid in weight loss. That’s why we have put together an effective core strengthening exercise routine that can help with PCOS belly fat. Veera is the world’s largest PCOS management online clinic that provides personalised treatment plans developed by top doctors and experts across the world. If you are looking to build sustainable habits across nutrition, exercise, sleep, and stress, join @veerahealth PCOS reversal program today. Supplement these exercises with balanced nutrition to see lasting results: Hollow under knee claps - ideal for strengthening your core, which includes your lower back muscles and obliques. Plank Hold - works the entire core & helps achieve better body balance, posture, as well as coordination. Climbers - climbers are great for building cardio endurance, core strength, and agility. Leg Raises - Leg raises strengthen the lower abdominal muscles. Weighted Sit Ups - an effective move for strengthening and tightening your abdominal muscles. Added weight = added calorie burn Weighted Russians - works on the obliques, abs, and lats. strengthens and challenges core. great calorie burners. Increasing the intensity and/or adding weights to the exercise helps burn more calories Heel Taps - activates the abdominal muscles along the sides of your body. Help increase stability and flexibility. Plank Jacks - combined cardio and core-strengthening exercise. Help you strengthen the muscles of both the upper and lower body. #pcosdiet #shorts #trending #pcosyoga #yoga #workout #diet #nutrition #bellyfat #burnfat #trainer #exercise #pcosawareness
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Week 2 of my Mounjaro journey is officially in the books! In this update, I share how much weight I’ve lost so far, the side effects I didn’t experience, and a few surprises—like hearing my stomach growl for the first time on Day 6 and feeling actual hunger on Day 7. I also talk about changing my injection site and taking the 3rd shot in my arm. #mounjarojourney #week2update #mounjaroresults #weightlossafter50 #mounjaro #mounjaroupdate #mounjaroexperience #mounjaroweightloss ###ozempicalternative #weightlossstory
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