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Apports des agonistes du récepteur du GLP-1 (GLP1-RA) dans le traitement du diabète et la protection cardiovasculaire par le Pr B. Charbonnel. Le Pr. Charbonnel a d’abord rappelé que le diabète était avant tout une maladie vasculaire, avec des complications à la fois microvasculaires (rétinopathie, neuropathie, néphropathie) et macrovasculaires (cardiaques) et qu’un bon contrôle glycémique (valeur cible d’HbA1C ≤7%) permettait de réduire ces complications (surtout microvasculaires). A côté des antidiabétiques classiques, une nouvelle classe de médicaments, les incrétines, permet d’atteindre cette cible : il s’agit des agonistes du récepteur du GLP-1 (glucagon-like peptide-1). Le GLP-1 est une hormone digestive, produite au moment des repas, qui stimule l’insuline et freine le glucagon. Donnée d’importance, son action est glucorégulée, ç.à.d. que lorsque la glycémie approche de la normale, cette hormone n’est plus stimulée, ce qui évite le risque d’hypoglycémie. Il existe deux approches pharmacologiques pour augmenter le GLP-1 : soit maintenir le taux de GLP-1 endogène en recourant à des inhibiteurs de sa dégradation enzymatique, soit remplacer l’hormone par des agonistes du récepteur de GLP-1 (GLP-1 RA). Deux principaux agonistes : le liraglutide (commercialisé en France) qui agit sur environ 24 heures et requiert donc une injection sous-cutanée quotidienne, et le dulaglutide qui agit sur plus d’une semaine. A côté de leur efficacité hyplogycémiante puissante, ces composés entraînent une perte pondérale. Ils sont globalement bien tolérés (troubles digestifs dans 20% des cas). Mais outre un antidiabétique, le GLP-1-RA est aussi un protecteur cardiovasculaire, ainsi qu’il a été démontré pour le liraglutide par l’étude LEADER portant sur 9340 patients atteints d’un diabète de type 2. Le mécanisme de cet effet reste à élucider. Il est possible qu’à côté d’une sommation de bénéfices métaboliques (réduction de la glycémie, du poids, de la tension artérielle), le GLP-1 exerce une action directement vasculaire. Ainsi émerge aujourd’hui un nouveau paradigme pour lutter contre les complications du diabète de type 2 : non seulement réduire l’hyperglycémie mais recourir à des médicaments antidiabétiques ayant démontré un bénéfice cardiovasculaire dont le liraglutide. Retrouvez l'intégralité de la séance ➡️ http://www.academie-medecine.fr/seance-commune-du-10-avril-2018-des-commissions-therapeutique-pharmacologie-toxicologie-medicaments-et-autres-produits-de-sante-et-maladies-cardiovasculaires-et-appareil-digestif-nutrit/ Et suivez l'actualité de l'Académie nationale de médecine sur TWITTER : @acadmed
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Lean Time Keto has been making waves in the weight loss industry ever since its appearance on Shark Tank. Known as the “Lean Machine,” this revolutionary product has helped countless individuals achieve their weight loss goals in a safe and effective manner.
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Lean Time Keto is based on the principles of ketosis, a natural metabolic state where the body burns fat for energy instead of carbohydrates. By following a keto-friendly diet and incorporating Lean Time Keto into their routine, users can accelerate fat burning and achieve faster weight loss results.
Lean Time Keto contains a proprietary blend of ingredients that have been scientifically proven to support ketosis and promote fat loss. These ingredients work synergistically to suppress appetite, boost metabolism, and increase energy levels, making it easier for users to stick to their weight loss goals.
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Fat loss doesn’t mean giving up your favorite foods—it means making smart swaps. 👉 Full-fat cheese? Try low-fat.👉 Regular ketchup? Go sugar-free.👉 Love tacos? Keep them—just tweak them. Small changes are easier to stick with, and they add up over time. You don’t need a big lifestyle overhaul—just consistent, smarter choices. Try, adjust, and keep moving forward. And as always, GET AFTER IT🦁
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Always double and triple check your dose! Contact your provider with issues. Units don’t mean anything without a concentration. I am an expert in humanizing the patient care experience by serving both patients and providers. Check out our practice at AMSTelehealth.com and our free FB group at AMSPublicGroup.com - longer vids are at WatchAMS.com and our new #ytpodcast is up! FreedomInMedicine.com 👍🏻🔔 Keep an eye out for the new provider focused page!!! ‘Til then I’m easy to find!! 📧 from our site or comment! ***All content on this channel and other social media accounts by AMS or Dr. Moe is general advice and should NOT be construed as medical advice, nor does it confer a patient - doctor relationship. This is NOT a HIPAA compliant space. *** #wtloss #weightmaintenance #stress #bingeeating #weightmanagement #glp1 #bettertogether #lifestylemedicine #obesitymedicine #medication #medicationmanagement Find all my content: https://linktr.ee/doctormoe
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