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#diabetes #weightloss #antihungermedicine Weight loss by diabetes drug linked to "anti-hunger" molecule, finds study Researchers from Stanford Medicine and Harvard Medical School have discovered an “anti-hunger” molecule that is produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The finding published in the journal Nature Metabolism revealed the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite which may help to discover a new class of weight loss drugs. Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug. Although this amount of weight loss is modest when compared with the 15% or more often seen by people taking semaglutide drugs, the discoveries that led to those drugs also grew from observations of relatively minor, but reproducible, weight loss in people taking first-generation versions of the medications. “Until now, the way metformin, which is prescribed to control blood sugar levels, also brings about weight loss has been unclear,” said Jonathan Long, PhD, an assistant professor of pathology. “Now we know that it is acting through the same pathway as vigorous exercise to reduce hunger. Understanding how these pathways are controlled may lead to viable strategies to lower body mass and improve health in millions of people.” The researchers observed obese laboratory mice who were given metformin and found increased levels of lac-phe in their blood. They ate less than their peers and lost about 2 grams of body weight during the nine-day experiment. In the study, Long and colleagues analyzed blood plasma samples from people with Type 2 diabetes before and 12 weeks after starting metformin treatment. They found significant increases in lac-phe levels post-metformin. Additionally, among 79 participants in a multi-ethnic atherosclerosis study taking metformin, those on the drug had higher circulating lac-phe levels compared to non-users. Moreover, a statistical analysis of individuals in the atherosclerosis study who experienced weight loss over the study and follow-up period revealed a significant connection between metformin usage, lac-phe production, and weight reduction. “It was nice to confirm our hunch experimentally. The magnitude of effect of metformin on lac-phe production in mice was as great as or greater than what we previously observed with exercise. If you give a mouse metformin at levels comparable to what we prescribe for humans, their lac-phe levels go through the roof and stay high for many hours.” said Long. “These findings suggest there may be a way to optimize oral medications to affect these hunger and energy balance pathways to control body weight, cholesterol and blood pressure. I think what we’re seeing now is just the beginning of new types of weight loss drugs.” Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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When it comes to natural health remedies, apple cider vinegar is often at the top of the list. Bragg Apple Cider Vinegar, in particular, has gained a reputation for its numerous health benefits and is a popular choice among health-conscious individuals. Available at Dischem, Bragg Apple Cider Vinegar is a versatile product that can be used for a wide range of health and wellness purposes. In this article, we will explore the various ways in which Bragg Apple Cider Vinegar can be used to boost your overall health and well-being.

Supports Digestive Health

One of the key benefits of Bragg Apple Cider Vinegar is its ability to support digestive health. The vinegar contains probiotics that can help maintain a healthy balance of gut bacteria, which is essential for proper digestion. Drinking a daily dose of Bragg Apple Cider Vinegar diluted in water or adding it to your meals can help improve digestion and prevent common digestive issues such as bloating, gas, and indigestion.

Furthermore, Bragg Apple Cider Vinegar is believed to have antibacterial properties that can help kill harmful bacteria in the digestive tract, reducing the risk of infections and promoting overall gut health. Regular consumption of Bragg Apple Cider Vinegar may also help regulate stomach acid levels, which can improve digestion and prevent conditions such as acid reflux and heartburn.

In addition to its digestive benefits, Bragg Apple Cider Vinegar may also help regulate blood sugar levels, making it a valuable supplement for individuals with diabetes or insulin resistance. The vinegar has been shown to improve insulin sensitivity and reduce blood sugar spikes after meals, which can help control diabetes and prevent complications associated with high blood sugar levels.

Boosts Immune System

Another key benefit of Bragg Apple Cider Vinegar is its ability to boost the immune system. The vinegar contains antioxidants and vitamins that can help strengthen the body’s defenses against infection and disease. Drinking Bragg Apple Cider Vinegar on a regular basis can help improve immunity and reduce the risk of common illnesses such as colds, flu, and infections.

Bragg Apple Cider Vinegar is also believed to have anti-inflammatory properties that can help reduce inflammation in the body, which is linked to a wide range of chronic health conditions. By reducing inflammation, Bragg Apple Cider Vinegar may help prevent diseases such as arthritis, heart disease, and cancer, and promote overall health and well-being.

Furthermore, Bragg Apple Cider Vinegar has alkalizing properties that can help balance the body’s pH levels, creating an environment that is less hospitable to harmful pathogens and bacteria. By maintaining a healthy pH balance, Bragg Apple Cider Vinegar can support the immune system and improve overall health.

Promotes Weight Loss

For those looking to shed excess pounds, Bragg Apple Cider Vinegar can be a valuable tool in their weight loss journey. The vinegar has been shown to increase feelings of fullness and reduce appetite, which can help prevent overeating and promote weight loss. By drinking a small amount of Bragg Apple Cider Vinegar before meals, individuals can curb their cravings and consume fewer calories throughout the day.

Additionally, Bragg Apple Cider Vinegar is believed to help boost metabolism, which can increase the body’s ability to burn fat and promote weight loss. The vinegar has been shown to increase the production of enzymes that break down fat, allowing the body to more efficiently convert stored fat into energy. By incorporating Bragg Apple Cider Vinegar into their daily routine, individuals can support their weight loss goals and achieve a healthier, slimmer physique.

Furthermore, Bragg Apple Cider Vinegar may help regulate blood sugar levels, which can prevent spikes in insulin and reduce the risk of storing excess fat in the body. By stabilizing blood sugar levels, Bragg Apple Cider Vinegar can promote weight loss and prevent obesity-related health conditions such as diabetes and heart disease.

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In addition to its internal health benefits, Bragg Apple Cider Vinegar can also be used topically to improve the health of the skin and hair. The vinegar contains acetic acid, which has antibacterial and antifungal properties that can help treat various skin conditions such as acne, eczema, and dandruff. By applying diluted Bragg Apple Cider Vinegar to the skin or scalp, individuals can soothe irritation, reduce inflammation, and promote healing.

Furthermore, Bragg Apple Cider Vinegar can help balance the skin’s pH levels, which can reduce the risk of breakouts and promote a clear, radiant complexion. The vinegar can be used as a toner or facial cleanser to tighten pores, remove impurities, and improve overall skin texture. Additionally, Bragg Apple Cider Vinegar can be used as a hair rinse to remove buildup, improve shine, and promote healthy hair growth.

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Conclusion

In conclusion, Bragg Apple Cider Vinegar is a natural health booster that can be a valuable addition to your daily routine. Available at Dischem, Bragg Apple Cider Vinegar offers numerous health benefits that can support digestion, boost immunity, promote weight loss, and improve skin and hair health. By incorporating Bragg Apple Cider Vinegar into your diet and beauty regimen, you can enhance your overall health and well-being in a safe and natural way.

Whether you are looking to improve your digestive health, strengthen your immune system, lose weight, or enhance your skin and hair health, Bragg Apple Cider Vinegar has something to offer for everyone. Start experiencing the benefits of Bragg Apple Cider Vinegar today and take a step towards a healthier, happier life.

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Semaglutide is a medication that has been gaining attention for its potential to aid in weight loss in individuals who are not diabetic. Originally developed as a treatment for type 2 diabetes, semaglutide has shown promising results in clinical trials for weight management in non-diabetic patients. Understanding how semaglutide works for weight loss in non-diabetics involves exploring the mechanisms by which this medication affects the body’s metabolism and appetite control.

Mechanisms of Action

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These medications work by mimicking the effects of GLP-1, a hormone produced naturally in the body that regulates blood sugar levels and food intake. When semaglutide is injected, it activates GLP-1 receptors in the brain and throughout the body, leading to a variety of physiological changes that can contribute to weight loss.

One of the key mechanisms by which semaglutide promotes weight loss is by slowing down the emptying of the stomach. This delay in gastric emptying can help individuals feel fuller for longer periods after eating, leading to reduced calorie intake over time. In addition, semaglutide has been shown to reduce hunger cravings and increase feelings of satiety, further supporting its ability to aid in weight management.

Another important aspect of semaglutide’s mechanism of action is its effects on energy expenditure. Studies have indicated that individuals taking semaglutide may experience an increase in resting metabolic rate, meaning that they burn more calories even when at rest. This can contribute to greater overall weight loss when combined with a balanced diet and regular physical activity.

Benefits of Semaglutide for Weight Loss

The potential benefits of using semaglutide for weight loss extend beyond its effects on appetite and metabolism. Clinical trials have demonstrated that individuals taking semaglutide may experience significant reductions in body weight compared to a control group receiving a placebo. In some cases, weight loss of 10% or more of initial body weight has been reported, representing a substantial improvement in overall health and well-being.

In addition to promoting weight loss, semaglutide has been associated with improvements in cardiovascular risk factors such as blood pressure, cholesterol levels, and blood sugar control. These benefits are particularly relevant for individuals who are overweight or obese, as they are more likely to develop conditions such as heart disease, diabetes, and stroke. By addressing both weight management and cardiovascular health, semaglutide has the potential to reduce the risk of future chronic diseases.

Furthermore, semaglutide has been well-tolerated in clinical trials, with relatively few side effects reported. Common side effects may include nausea, vomiting, and diarrhea, especially when first starting the medication. However, these symptoms typically subside over time as the body adjusts to the medication. Overall, the safety profile of semaglutide for weight loss appears favorable compared to other weight management strategies.

Considerations for Use

Before considering treatment with semaglutide for weight loss, individuals should consult with a healthcare provider to determine if this medication is appropriate for their unique needs. Semaglutide is typically prescribed for individuals who have a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity such as hypertension or dyslipidemia. Healthcare providers will evaluate the potential risks and benefits of semaglutide in each individual case.

It is important to note that semaglutide is not a standalone solution for weight loss and should be used in conjunction with a comprehensive approach that includes a healthy diet, regular physical activity, and behavior modifications. Individuals taking semaglutide should work closely with their healthcare provider to establish realistic goals and monitor their progress over time. By combining semaglutide with lifestyle changes, individuals can maximize the benefits of this medication for long-term weight management.

In conclusion, semaglutide offers a promising option for individuals seeking effective and sustainable weight loss solutions. By understanding the mechanisms of action and potential benefits of semaglutide, non-diabetic patients can make informed decisions about incorporating this medication into their weight management plans. With careful consideration and guidance from healthcare providers, semaglutide has the potential to significantly impact the lives of individuals struggling with obesity and its associated health risks.

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