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Weight loss is a common goal for many individuals, whether it be for health reasons or personal aesthetics. With the rise in obesity rates around the world, there has been a surge in research and development of medications that can aid in weight loss. Two medications that have gained attention in recent years are semaglutide and tirzepatide. Both medications have shown promising results in helping individuals lose weight, but which one is more effective?

Semaglutide

Semaglutide is a medication that belongs to a class of drugs known as GLP-1 receptor agonists. It works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) that is naturally produced by the body. This hormone helps to regulate blood sugar levels and appetite. Studies have shown that semaglutide can help individuals lose weight by reducing appetite and promoting feelings of fullness.

Semaglutide is typically administered as a subcutaneous injection once a week. It has been approved by the FDA for the treatment of obesity in individuals with a BMI of 30 or higher, or a BMI of 27 or higher with at least one weight-related comorbidity. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation.

Research has shown that individuals who take semaglutide can experience significant weight loss compared to those who take a placebo. In clinical trials, participants who took semaglutide lost an average of 15-20% of their body weight, making it a promising option for individuals struggling with obesity.

Tirzepatide

Tirzepatide is another medication that has shown promising results in aiding weight loss. It is a dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist. This means that it targets two different hormones that play a role in regulating blood sugar levels and appetite. Tirzepatide has been found to have a stronger effect on weight loss than other GLP-1 receptor agonists.

Unlike semaglutide, tirzepatide is administered as a subcutaneous injection once a week. It has been studied in individuals with obesity and type 2 diabetes, as well as in individuals without diabetes. Common side effects of tirzepatide include nausea, vomiting, diarrhea, and injection site reactions.

In clinical trials, tirzepatide has been shown to lead to significant weight loss in individuals with obesity. Participants who took tirzepatide lost an average of 10-15% of their body weight, making it a competitive option to consider for weight loss treatment.

Comparison

When comparing semaglutide and tirzepatide for weight loss, several factors should be taken into consideration. Semaglutide has been studied in individuals with obesity and has shown to lead to greater weight loss compared to tirzepatide. On the other hand, tirzepatide has been found to have a stronger effect on weight loss than other GLP-1 receptor agonists, including semaglutide.

Both medications have been associated with similar side effects, such as nausea, vomiting, and diarrhea. The choice between semaglutide and tirzepatide may depend on individual preferences, tolerability, and response to treatment. It is important to consult with a healthcare provider to determine the most suitable option for weight loss treatment.

In conclusion, both semaglutide and tirzepatide are promising medications for weight loss. They have shown to be effective in helping individuals lose weight and improve overall health. Further research is needed to determine the long-term effects and safety profile of these medications. In the meantime, individuals interested in weight loss treatment should discuss their options with a healthcare provider to make an informed decision.

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It was such a pleasure to get to talk more with Dr. Josef about his approach to mental health care as a psychiatrist specializing in deprescribing and safe tapering of psychiatric medications. There is a pervasive assumption within psychiatry that these medications are necessary and dangerous to suggest coming off of - but that framework often does a disservice to prioritizing the patient's quality of life and various other life and health factors. Thank you so much Dr. Josef for sharing your perspective and approach to psychiatry with us. You can learn more about Dr. Josef and The Taper Clinic here: YouTube - @taperclinic Website - https://taperclinic.com/ Instagram and TikTok - @taperclinic Timestamps: 00:00 - Introduction to Dr. Josef 00:52 - Is Dr. Josef against psychiatric medications? 02:20 - Dr. Josef's background and how he came to helping people taper off psychiatric medications 10:30 - What does The Taper Clinic do? 14:05 - What are the basic principles of safe tapering? 18:15 - Why taper instead of just abruptly stopping the medication? 21:20 - Is there any way to manage withdrawal symptoms? 22:45 - How do you consider individual circumstances in psychiatric care and tapering? 24:56 - Overcoming a siloed health care system - need to look at health as a whole! 27:40 - Which psychiatric medications are the most difficult to taper off of? 31:20 - What is often the most challenging part of tapering psych meds? 34:22 - Addressing trauma around deprescribing or medication tapering + feeling safe navigating tapering 38:00 - What role should a prescriber play in the deprescribing process? Who else could I add to my care team to support this process? 44:22 - Advice for self advocating with a prescriber who may be adverse to deprescribing 48:56 - What has the reaction to taking this different approach to psychiatric care been like? 51:52 - There needs to be more room to have these conversations 57:00 - Message of hope or empowerment for people navigating psychiatric medications and care *MEDICAL KETO RESOURCES* Learn more about medical keto for mental illness: • Metabolic Mind YouTube channel: youtube.com/@metabolicmind and website: www.metabolicmind.org • My keto coach, Nicole Laurent’s website: http://www.mentalhealthketo.com • Brain Energy by Dr. Christopher Palmer: http://www.brainenergy.com *JOIN OUR COMMUNITIES* • Metabolic Therapies for Mental Disorders: http://www.metabolictherapysupport.com • Schizophrenia Peer Support Community: http://www.schizophreniapeersupport.com *HOW TO TEST YOUR KETONES* (important for medical keto!) • Keto Mojo Monitor: Finger prick test for ketone and glucose levels. Save 10% with our affiliate link: http://bit.ly/ketomojolivingwell • SiBio Continuous Monitor: Wearable for continuous ketone tracking. Save 15% with code “LIVINGWELL15” and link: http://bit.ly/sibio *SPEAKING & CONSULTING* Looking for a mental health advocate for your event or project? Learn more: http://www.laurenkennedywest.com *MENTAL HEALTH APPAREL* Support the channel and spread awareness with our apparel: http://livingwell.myspreadshop.com *FOLLOW US ON SOCIALS* • Instagram: https://www.instagram.com/livingwellwithschizophrenia • TikTok: https://www.tiktok.com/@livingwellschizophrenia • X: https://x.com/LWSchizophrenia • Website: http://www.livingwellafterschizophrenia.com #schizophrenia #schizoaffective #schizoaffectivedisorder #mentalhealth #mentalillness #medication #tapering

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