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GLP-1 drugs have revolutionized treatment for type 2 diabetes and obesity and have shown promise for other conditions, such as heart failure, chronic kidney disease, and sleep apnea. Much of the foundational research on GLP-1, a hormone that helps regulate blood sugar, was conducted by Joel Habener and colleagues at Harvard Medical School and its affiliated hospitals with funding support from the National Institutes of Health. Their findings informed the design of therapies that mimic GLP-1’s effects in the body. The FDA approved the first GLP-1 medication for type 2 diabetes in 2005 and has approved multiple others for diabetes and obesity since. As of 2024, around 12 percent of U.S. adults had used one of these drugs. HMS Associate Professor Fatima Cody Stanford explains the road from basic research to clinical care and the transformational impact of these medications.

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