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Quinine, a common ingredient in tonic water, can suppress appetite and cause weight loss, but it has a host of potential side effects and is an extremely toxic agent in overdose. New subscribers to our e-newsletter always receive a free gift. Get yours here: https://nutritionfacts.org/subscribe/. Have a question about this video? Leave it in the comment section at http://nutritionfacts.org/video/natural-ozempic-alternatives-boosting-glp-1-with-diet-and-lifestyle and someone on the NutritionFacts.org team will try to answer it. Want to get a list of links to all the scientific sources used in this video? Click on Sources Cited at https://nutritionfacts.org/video/natural-ozempic-alternatives-boosting-glp-1-with-diet-and-lifestyle. You’ll also find a transcript and acknowledgements for the video, my blog and speaking tour schedule, and an easy way to search (by translated language even) through our videos spanning more than 2,000 health topics. Thanks for watching. I hope you’ll join in the evidence-based nutrition revolution! -Michael Greger, MD FACLM Captions for this video are available in several languages; you can find yours in the video settings. View important information about our translated resources: https://nutritionfacts.org/translations-info/ https://NutritionFacts.org • Subscribe: https://nutritionfacts.org/subscribe • Donate: https://nutritionfacts.org/donate • Podcast : https://nutritionfacts.org/audio • Books: https://nutritionfacts.org/books • Shop: https://drgreger.org • Facebook: https://www.facebook.com/NutritionFacts.org • Twitter: https://twitter.com/nutrition_facts • Instagram: https://www.instagram.com/nutrition_facts_org

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#semaglutide #obesitymedicine #type2diabetes If you are interested in licensing this animation or creating a new one, visit our website: https://nmal.nucleusmedicalmedia.com/contact-form?f=misc MEDICAL ANIMATION TRANSCRIPT: Semaglutide is a medicine used to help control high blood sugar in people who have type 2 diabetes. It may also be used to help people with excess weight or who have obesity to lose weight. For those who have type 2 diabetes and heart disease, this medicine is also approved to help reduce the risk of heart attack, stroke, or death. In order to understand how semaglutide works, it's important to know how your body controls blood sugar levels. Your pancreas is an organ that helps control the amount of sugar in your blood called glucose. When your digestive track breaks down foods such as carbohydrates into glucose, it begins to release the glucose into the blood stream. The glucose in your digestive track triggers it to release a chemical called glucagon-like peptide-1 or GLP-1. GLP-1 slows the movement of food out of your stomach, which slows the movement of glucose into your blood. This helps slow down the rise in blood glucose after you eat. GLP-1 also causes your pancreas to release a hormone called insulin. Insulin helps your body's cells use glucose for energy, which lowers the amount of glucose in your blood. If your blood sugar is too low instead of releasing insulin, your pancreas releases a different hormone called glucagon. Glucagon helps your liver make glucose. Your liver releases it into the bloodstream which raises your blood sugar. If you have type 2 diabetes, your body can't control blood sugar levels properly. For example, your digestive track may release less GLP-1, leading to less insulin release. In addition, your pancreas may not be able to make enough insulin or your cells may resist its effect or both. And your pancreas may also release glucagon at the wrong times. This can cause your liver to release glucose into the blood even if your glucose levels aren't low. Since your cells can't use all this extra sugar, it begins to build up in your blood. This is called hyperglycemia. Over time, untreated hyperglycemia can damage your nerves and blood vessels. This damage can lead to disease in some parts of your body such as the feet, brain, eyes, heart, and kidneys. If you have type 2 diabetes and have excess weight, you may have hidden fat called visceral fat around the organs in your belly. This type of fat may cause your body's cells to resist the effects of insulin so that they can't effectively use the glucose in your blood. Semaglutide medicines are part of a class of drugs called GLP-1 agonists. You take them by injection or by mouth as tablets. GLP-1 agonists act like the GLP-1 that your body makes. In treating type 2 diabetes, the goal of semaglutide medicines is to prevent hyperglycemia or high blood sugar. They do this by acting like GLP-1 to cause your pancreas to make more insulin when blood sugars are high, which allows your cells to use the sugar in your blood. They can also help stop the inappropriate release of glucagon from your pancreas, which stops your liver from putting glucose into your blood stream at the wrong times. Semaglutide medicine for weight loss acts like GLP-1 to help slow the movement of food out of your stomach. Since this increases the feeling of fullness, it can help you eat less. Semaglutide may also act on the hunger areas of your brain to decrease your appetite. And if you have type 2 diabetes, semaglutide medicines can help you lose weight, including visceral fat. As a result, your cells are less likely to resist that effects of insulin to use glucose in your blood. Semaglutide's more common side effects are mild to moderate stomach and bowel problems such as nausea, vomiting, and diarrhea. There is a risk for low blood sugar called hypoglycemia if you're also taking other medicines that lower blood sugar such as insulin or sulfonylureas, but GLP-1 medicines like semaglutide are unlikely to cause hypoglycemia when taken alone or in combination with metformin, which is a medicine used to treat type 2 diabetes. To find out more about semaglutide, talk to your healthcare practitioner. ANH24276 Visit our website to learn more about using Nucleus content for patient engagement and content marketing: http://www.nucleushealth.com/

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With the rise of obesity rates worldwide, there has been an increased interest in medications that can aid in weight loss. Two drugs that have gained attention for their potential in promoting weight loss are semaglutide and tirzepatide. Both drugs belong to a class of medications known as GLP-1 receptor agonists, which work by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1) that regulates blood sugar levels and appetite.

Comparing Effectiveness of Semaglutide and Tirzepatide

Semaglutide and tirzepatide have both shown promising results in clinical trials for weight loss, but they have some key differences in terms of their effectiveness and side effects. In this article, we will compare the two drugs and discuss their pros and cons to help you make an informed decision about which medication may be right for you.

Mechanism of Action

Semaglutide works by stimulating the release of insulin, reducing glucagon secretion, slowing gastric emptying, and suppressing appetite. This multifaceted approach makes it a potent weight loss medication. On the other hand, tirzepatide is a dual GIP and GLP-1 receptor agonist, meaning it targets two different pathways to regulate blood sugar levels and appetite. This dual mechanism of action could potentially make tirzepatide more effective for weight loss than semaglutide.

Clinical Efficacy

In clinical trials, both semaglutide and tirzepatide have been shown to help patients lose significant amounts of weight. Semaglutide has been studied in the STEP trials, which included participants with obesity or overweight who also had other health conditions such as type 2 diabetes. The results showed that semaglutide led to an average weight loss of around 15-17% of initial body weight. Tirzepatide has also shown promising results in clinical trials, with some studies reporting weight loss of up to 20% of initial body weight.

Side Effects

Both semaglutide and tirzepatide can cause side effects such as nausea, vomiting, diarrhea, and constipation. However, tirzepatide may have a higher risk of gastrointestinal side effects compared to semaglutide. Additionally, tirzepatide may be associated with an increased risk of hypoglycemia (low blood sugar levels) compared to semaglutide. It is important to discuss the potential side effects of each medication with your healthcare provider before starting treatment.

Cost and Accessibility

Another important factor to consider when choosing between semaglutide and tirzepatide is the cost and accessibility of the medications. Semaglutide is currently available as an injectable medication that is typically taken once a week. Tirzepatide, on the other hand, is still in development and has not yet been approved for use. The cost of these medications may vary depending on your insurance coverage and location, so it is important to consider these factors when making a decision.

Overall, both semaglutide and tirzepatide have shown promise as effective weight loss medications for individuals with obesity or overweight. It is important to consult with your healthcare provider to determine which medication may be right for you based on your individual needs and preferences. Remember that weight loss medications should be used in conjunction with a healthy diet and exercise regimen for the best results.

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