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Click Here to Subscribe: http://Bit.ly/ThomasVid Website: http://ThomasDeLauer.com Get the Apparel I Wear at http://Hylete.com Ketogenic Diet vs. Kidneys | Keto’s Effect on the Kidneys | Kidneys Stones Explained- Thomas DeLauer… Keto & Gene Expression: A study published in the journal Kidney International looked at nephropathy (term used when the kidneys start to incur damage, which can ultimately lead to kidney failure) in diabetic mice (3) The researchers found the genes responsible for nephropathy (nephrin, ZO-1 and podocin) were reversed - this helped restore the mice’s kidneys back to healthy functioning. Specifically, the study found that keto increased the expression of SIRT1, which led to a reduction in the genes responsible for nephropathy. In indications of energy surplus, such as glycogen and insulin, inhibit activation of AMPK - ketosis decreases these factors that inhibit AMPK. Through a very long process ketosis is able to activate SIRT1 indirectly through activation of AMPK. https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2781128 SIRT1: SIRT1 is a protein or vehicle that requires NAD+ to function - SIRT1 takes acetyl groups off of proteins. SIRT enzymes “turn off” certain genes that promote aging, such as those involved in inflammation, in fat synthesis and storage, and in blood sugar management. When proteins are undergoing stress, acetyl groups are added to proteins as a response to changes induced by inflammation and oxidation. Sirtuins (like SIRT1) remove these acetyl groups to keep the protein in service longer than usual, while simultaneously stabilizing the charge state of the carbon backbone in protein to resist any further changes in their shape. This allows your cellular proteins to live longer and you can save energy on other processes. Keto & Glomerular Lesions: Glomerular filtration rate (GFR) is a test to measure how well the kidneys filter blood and remove waste. Glomeruli, the small units within the kidney where blood is filtered - they act as tiny filters within the kidneys and each kidney contains millions of glomeruli. If the glomeruli become damaged, the kidney can no longer remove waste and excess fluids efficiently - blood and protein cannot be filtered and are excreted in the urine. Too much glucose may cause glomerular lesions in patients with poor glucose control, leading to impairment of the kidneys. Glomerulonephritis, a group of diseases that cause inflammation and damage to the kidney's filtering units - glomerulonephritis refers to a range of inflammatory kidney conditions of the tiny blood vessels in the kidneys. High glucose levels are thought to make the blood flow into the kidney at a higher speed, putting a strain on the filtering process and raising blood pressure. The capillaries in the glomerulus collapse and can leave the glomeruli with scarring. Meta Analysis - British Journal of Nutrition: The review measured the impact of low carb diet on renal function taking into account 1000 people from nine randomised controlled trials found that: “a low carbohydrate diet and the corresponding high-protein diet was not harmful for renal function in overweight and obese individuals without renal dysfunction.” Furthermore, it concluded that a low carb diet may even improve renal function thanks to its weight loss effects. References: 1) Impact of low-carbohydrate diet on renal function: a meta-analysis of over 1000 individuals from nine randomised controlled trials. (2016, August 28). Retrieved from https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/impact-of-lowcarbohydrate-diet-on-renal-function-a-metaanalysis-of-over-1000-individuals-from-nine-randomised-controlled-trials/0EAA25E700C06D2C5125F0AB195FB33F 2) University of Wisconsin Hospitals and Clinics Authority. (2010, June 24). How Do Kidney Stones Form? Retrieved from https://www.uwhealth.org/urology/how-do-kidney-stones-form/11210 3) Nesbitt, H. (n.d.). Kidney Week. Retrieved from https://www.asn-online.org/education/kidneyweek/2017/program-abstract.aspx?controlId=2781128 4) Hong Q , et al. (n.d.). Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29477240 5) Nutritional Ketosis and Mitohormesis: Potential Implications for Mitochondrial Function and Human Health. (2018, February 11). Retrieved from https://www.hindawi.com/journals/jnme/2018/5157645/

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A founder of a keto beverage company was the last entrepreneur to pitch their keto product on shark tank. They had created a range of low-carb, high-fat beverages that were specially formulated for ketogenic dieters. The sharks loved the taste and quality of the drinks as well as the entrepreneur’s dedication towards promoting healthy living; hence they managed to win over one of the Sharks who believed that it could become a household name in the ketogenic community.

Entrepreneur #6: Keto Friendly Restaurant

The other entrepreneur who pitched his keto product in Shark Tank was an owner of a keto friendly restaurant. He had founded this eatery to serve people trying to follow a ketogenic diet with meals which would conform to the recommended macronutrient levels. The sharks were fascinated by this subscription-based business model and its potential for repeat customers paying monthly fees. Eventually, many buyers came calling including several sharks who wanted to make it bigger and more popular among fitness enthusiasts.

Entrepreneur #7: Keto Cookbook Author

Another entrepreneur made her pitch for Keto products on Shark Tank Show who is an author owning a cookbook dedicated only for those interested in Ketogenic Diet plans. Some of these supplements are exogenous ketones, MCT oil, electrolyte blends and so forth. In addition, what amazed them most about these products is their scientific research background and customer reviews from users who have benefited from some of them and developed outstanding health records through this method. A notable issue however cropped up when one shark viewed this company as promising especially since there is little knowledge concerning efficacy of ketone supplements; thus he generously unveiled his idea for moving into the future by making a fair offer.

Entrepreneur #8: Keto Gym

The final person presented before The Shark Tank audience was an owner of Keto gymnasiums that offers special facilities for people engaged in ketogenic diets awareness programs. For instance, the app has been designed specifically targeting those clients following Ketogenic diets with several hundreds of delicious Keto-friendly recipes, meal plans and shopping lists. The sharks were impressed by the app’s simplicity and the potential for it becoming a central source of information in respect to ketogenic dieting. Additionally, even though there is competition in this segment of application development, another shark saw more potential in the entrepreneur’s ideas and expertise in that industry thus they entered into an agreement just prior to concluding the show.

Entrepreneur #9: Keto Clothing Line

The last entrepreneur to pitch his keto product on Shark Tank was a ketogenic beverage business owner who had come up with low-carb, sugar-free drinks that targeted health-conscious consumers seeking healthier alternatives to traditional sodas and energy drinks. The novelty formulation of the products was quite impressive to the sharks, who thought that this could revolutionize the drink world in future. Following an intense competition between many sharks, the entrepreneur managed to strike a deal that would help him take his business to higher levels and attract more keto enthusiasts.

In summary, we can say that the episode of Shark Tank has highlighted how popular is the use of ketogenic diets as an alternative for people intending to make money through it. Some of these keto products were so good that they attracted great deals leading to successful negotiations by the sharks present in shark tank. It will be interesting to see how these businesses develop further and impact on health and wellness industry since demand for keto-friendly products continues growing.

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