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SEMAGLUTIDA La semaglutida es un medicamento que se usa para tratar la diabetes tipo 2 y para ayudar a bajar de peso: Diabetes tipo 2 La semaglutida se usa para reducir los niveles de azúcar en la sangre en adultos con diabetes tipo 2. Se puede administrar en forma de inyecciones o tabletas. Pérdida de peso La semaglutida se usa para ayudar a perder peso y mantenerlo en adultos y niños a partir de 12 años con obesidad o sobrepeso. Se administra en forma de inyecciones. La semaglutida es un análogo de la hormona GLP-1, que se libera en el tracto gastrointestinal después de comer y ayuda a reducir el apetito. La semaglutida actúa imitando la acción de la GLP-1. La semaglutida puede causar cambios en los niveles de azúcar en la sangre, por lo que es importante conocer los síntomas de niveles altos y bajos y saber qué hacer en caso de presentarlos. TIRZEPATIDA Administración de Alimentos y Medicamentos de los Estados Unidos (FDA, por sus siglas en inglés) aprobó la inyección de (tirzepatida) para el control crónico del peso en adultos con obesidad [índice de masa corporal de 30 kilogramos por metro cuadrado (kg/m2) o más] o con sobrepeso [índice de masa corporal de 27 kg/m2 o más] con al menos una afección relacionada con el peso (como presión arterial alta, diabetes tipo 2 o colesterol alto) para su uso, además de una dieta baja en calorías y mayor actividad física. Tirzepatida, el ingrediente activo de tirzepatida, ya está aprobado con el nombre comercial tirzepatida para usarse junto con dieta y ejercicio para ayudar a mejorar el azúcar en la sangre (glucosa) en adultos con diabetes mellitus tipo 2. Aproximadamente el 70 % de los adultos en los Estados Unidos tienen obesidad o sobrepeso, y muchos de ellos tienen una afección relacionada con el peso. Perder entre el 5 % y el 10 % del peso corporal mediante dieta y ejercicio se ha asociado con un riesgo reducido de enfermedad cardiovascular en adultos con obesidad o sobrepeso. tirzepatida activa los receptores de hormonas secretadas por el intestino [péptido 1 similar al glucagón (GLP-1) y polipéptido insulinotrópico dependiente de glucosa (GIP)] para reducir el apetito y la ingesta de alimentos. tirzepatida se administra mediante inyección subcutánea una vez a la semana y la dosis debe aumentarse durante un período de cuatro a 20 semanas para alcanzar las dosis objetivo de 5 miligramos (mg), 10 mg o 15 mg una vez a la semana. La dosis máxima de tirzepatida es de 15 mg una vez a la semana. RETATRUTIDE Retatrutide es el medicamento más reciente de una nueva clase de medicamentos con un gran potencial para la pérdida de peso y el tratamiento de la diabetes. El nuevo medicamento retatrutide está en fase de prueba para su uso en el tratamiento de la diabetes y la pérdida de peso. En 2021 se aprobó un fármaco similar para la pérdida de peso llamado semaglutida que cambió las reglas del juego y se agotó rápidamente. Retatrutide puede ser incluso más eficaz al actuar sobre tres hormonas relacionadas con el apetito en lugar de solo una. Un posible nuevo fármaco para la pérdida de peso se encuentra en investigación continua, inmediatamente después de otros medicamentos de gran éxito como la semaglutida, que están cambiando la forma en que la industria médica aborda el control del peso. Retatrutide es una inyección semanal de la compañía farmacéutica Eli Lilly, que está en proceso de completar los ensayos de fase 2 para estudiar el fármaco tanto para la pérdida de peso como para el control de la diabetes tipo 2. La prueba sigue a la aprobación del medicamento para bajar de peso semaglutida en 2021, un medicamento inyectable una vez por semana que se usó originalmente para tratar la diabetes. Los expertos lo llamaron un «cambio de juego» para la pérdida de peso y se agotó rápidamente. Un medicamento para la diabetes igualmente prometedor llamado tirzepatida, también una inyección semanal, está esperando la aprobación de la FDA para la pérdida de peso. Ambos funcionan imitando una hormona llamada GLP-1, que ayuda a regular el azúcar en la sangre y puede hacer que las personas se sientan llenas más rápidamente después de comer. Retatrutide funciona de manera similar, pero además de GLP-1, también actúa sobre otras dos hormonas. Uno, llamado polipéptido insulinotrópico dependiente de glucosa (GIP), también ayuda a controlar el azúcar en la sangre. El otro, llamado glucagón, puede ayudar a suprimir el apetito y aumentar el gasto de energía, por lo que come menos calorías y quema más, sugiere la evidencia. diabetes, podrían perder hasta el 24% de su peso corporal en 48 semanas, informó Investors Business Daily. Eso es más pérdida de peso a un ritmo más rápido que los resultados del ensayo de tirzepatida, que condujo a una reducción del 20% en el peso corporal en 72 semanas.
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