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incretin effect| incretin effect glp-1| incretin effect explained| incretin effect in diabetes| incretin hormones| incretin based therapy of diabetes ▪ Incretins are a group of metabolic hormones that stimulate a decrease in blood glucose levels. Gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are the two primary incretin hormones secreted from the intestine on ingestion of glucose or nutrients to stimulate insulin secretion from pancreatic β cells. The major mechanism of metabolism of the incretins is cleavage by dipeptidyl peptidase 4 (DPP4), an enzyme that is ubiquitously expressed, including in endothelial cells. ▪ Two pharmacological approaches have been taken to enhance the incretin effect in type 2 diabetes. One approach is to administer GLP-1 'analogues' (GLP-1 receptor agonists) that are resistant to cleavage by DPP4. The other approach is to inhibit DPP4 activity. This effectively increases the half-life and therefore the circulating concentrations of the incretins. ▪ In summary, Ingested glucose causes secretion of incretins from GI tract. These ingredients then increase insulin secretion from the pancreas. Anti-diabetic drugs targeting this mechanism are glp1 analogues and dpp4 inhibitors. And in this way, by increasing insulin secretion, the incretins lower blood glucose. Chapters: 0:00 - Insulin Secretion Mechanism 0:42 - Incretin Effect 1:10 - Incretin Hormones 1:26 - Glucagon-like peptide-1 (GLP-1) Hormone 2:19 - Problem in Diabetes 2:35 - GLP-1 analogues and DPP-4 inhibitors 3:24 - Summary of Incretin Effect incretin hormones, incretin effect, incretin effect glp-1, incretin effect explained, incretin effect in diabetes, insulin, diabetes, glucagon like peptide 1, incretin based therapy of diabetes, incretin pathway, incretin and glp-1, glp 1 analogs, dpp4 inhibitors, sitagliptin, vildagliptin, exenatide, liraglutide, oral antidiabetic drugs, mechanism of insulin secretion, insulin secretion, insulin physiology, insulin pharmacology, diabetes mellitus, medicine, pharmacyd by asim ☕ Buy Me A Coffee: https://www.buymeacoffee.com/pharmacyd 💡 Facebook: https://web.facebook.com/pharmacyd0929 For any Queries and Suggestions Email on: [email protected] Disclaimer: "Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition." A Famous Quote is: "What We Know is a Drop. What We Don't Know is an Ocean".
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The Keto Diet: A Revolution on Shark Tank That Transforms Weight Loss
The weight loss world has been taken by storm with the introduction of the Keto Diet and its endorsement in the reality show, Shark Tank. The Keto Diet, which stands for ketogenic diet, focuses on low-carb and high-fat foods that force your body to burn fat instead of carbohydrates for energy. This metabolic state is known as ketosis which has been associated with several health benefits such as weight loss, increased energy levels and mental sharpness. With support from the Sharks on Shark Tank, it has gained even more popularity and credibility making it possible for diet industry revolution.
How does this work?
At heart the idea of Keto Diet is Ketosis – a normal metabolic state where stored body fat is used up for fuel rather than carbohydrates. By significantly reducing carbohydrate intake and increasing fat consumption, the body has no option but to switch from using sugars to burning stored fats for energy. This causes not only weight reduction but also assists in regulating blood sugar levels, enhancing energy and boosting mental focus. In addition, the Ketogenic diet reduces inflammation in the body which can have positive effects on overall wellness.
Other than that there are many other non-weight loss related advantages of following a Keto Diet. Some studies have indicated that it may help to reduce cholesterol levels, lower cardiovascular disease risk factors and improve insulin sensitivity among others. While adhering to a keto type of eating many individuals also report fewer cravings as well as reduced appetite making them stick to healthy eating plans effortlessly. No wonder therefore that people looking forward to improving their own general health wellbeing are increasingly embracing this type of diet because of its far-ranging potential benefits.
Shark Tank Success Stories
A number of entrepreneurs have pitched their products based on ketogenic diets at Shark Tank which were backed by Sharks investing with them too who were interested in them. These success stories have both illustrated how effective this sort of diet can be while also bringing it to the forefront of people’s minds. From snacks that are keto-friendly to supplements as well as meal delivery services, Shark Tank has showcased products that provide people with practical ways to bring Keto Diet into their everyday lives. Through this, these entrepreneurs have been able to increase their market share and access a larger population, thereby contributing more towards the Keto Diet revolution.
One of the notable successes from Shark Tank was how quick Keto-friendly products transformed the diet industry. Such things like keto snacks or ketone supplements have seen an increased desire for them due to more people embracing Keto Diets. Entrepreneurs in Shark Tank say that they have experienced substantial growth in their businesses following appearances on the show because these Sharks helped them find new customers and expand product lines. It is now easier than ever before for individuals who want to stick on a ketogenic diet plan for weight loss purposes thanks to these options available.
FAQs: The Science Behind Ketosis
Q: What does eating in line with a Keto Diet entail?
A: The Keto Diet forces the use of high-fat, protein-rich foods such as meat, fish, eggs, dairy products, nuts, seeds and good fats. To maintain ketosis it is necessary to avoid things like starchy vegetables, grains, sugars or processed food.
Q: How fast will I start seeing results on Keto diet?
A: Results may differ depending on individual determinants like metabolism rate activity level and compliance with the diet. While some people may begin experiencing weight loss in a few weeks’ time; others might take more days to hit their targets.
Q: Is everyone able to follow the Keto Diet safely?
A: Nevertheless generally secure for most individuals; this kind of way of eating may not be appropriate for people suffering from particular illnesses or those with special dietary needs. Before starting any new diet or lifestyle change it is always advisable to consult a healthcare provider first.
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Can we build muscle without bulking? No, right? If you want to build muscle, you gotta bulk, right? I mean that’s what all the biggest guys in the gym seem to be doing. But bulking can actually be the WRONG way to build muscle for most people. Today I’ll share why that is and how you can build muscle without bulking up. Get ready for some of the best bulking tips you’ve ever seen. Click below for a step by step plan training plan that reveals all the best exercises you should do for each and every muscle group: https://quiz.builtwithscience.com/ Click below to subscribe for more videos: https://www.youtube.com/jeremyethier/?sub_confirmation=1 It was long believed that the only way for your body to get enough energy for the costly process of muscle growth was by being in a calorie surplus, aka “bulking”. However, the downside is that you put on a lot of fat in the process. I recently spoke with Dr. Eric Helms, and asked him if he thought bulking is the best way to build muscle. He said it depends upon who you are. If you are relatively new to lifting and you are within what we would call normative ranges of body fat, potentially it is. When I started lifting, my first bulk worked extremely well. But after that, I noticed my bulks became less and less effective. This got me thinking: is overeating really the only way to build muscle? Could we turn the excess fat on our bodies into muscle instead? Turns out, research shows you don’t need to be in a calorie surplus to build muscle. Dr. Eric Helms agrees that body recomposition is attainable. However, a disclaimer: is body recomp as efficient as an intermediate or advanced lifter being in a small surplus? Probably not. But it is one way, another approach that might fit someone better if they're already higher in body fat than they would like to be. Now does all this research mean bulking is useless? What if you’re not worried about fat loss and simply want to maximize growth? Well, if you're starting at an already high body fat percentage, it's totally fine to go into a surplus and put on muscle, just be aware that it's going to come with more body fat gain. And if you’re already close to where you're comfortable with the way you look, you might want to consider taking an approach where you're eating at maintenance or you're trying to lean gain (build muscle without bulking up), or you might decide to cut first before then eventually bulking. Now, some crucial bulking tips. It’s mostly beginners that benefit from bulking because they have the highest sensitivity to muscle growth. Bulking becomes less effective over time. That said, another “population” that benefits from traditional bulking would be Sam Salek and professional bodybuilders who take performance-enhancing drugs. Theoretically, when you're using anabolics, your ceiling goes up. This brings us back to the reality that for a natural lifter past the beginner stage, muscle growth is very slow. If you try to rush it, you’ll just gain more fat rather than muscle. You need to scale your diet based on your experience level and how sensitive you are to muscle growth. This brings us to the next question: how many calories should you be eating to build muscle while minimizing fat? If you’re a beginner, eat a daily calorie surplus of around 400-500 calories. Once you start to notice that it seems like it's mostly just fat coming on, you want to cut that calorie surplus probably in half roughly, and then just focus on progress in the gym. Try to gain just 1% of your body weight per month by using a small surplus of just 200 to 300 calories. Then, once you get into the advanced stage and are near your genetic ceiling of muscle growth, that’s when you dial it back even further by using a very small surplus. That said, unless you’re super analytical or really dedicated to your fitness goals, I’ll admit tracking all this stuff can get overwhelming especially if you’re trying to nail down a really small surplus. If this sounds like you then don’t worry about tracking anything. Just focus on eating lots of protein, healthy whole foods, and use your strength and your body weight to determine if you’re eating the right amount. If after a month you step on the scale and you’ve gained 10 lbs, then you know you gotta dial it back. On the other hand, if you lost weight and haven’t been getting stronger in the gym, then that’s a sign you gotta eat a bit more. Alright. To summarize, can we build muscle without bulking? Yes. But should you? It depends on where you’re at. For those who aren’t crazy lean and want to lose fat while building muscle, then eat just enough calories to maintain your weight or at a small deficit to lose no more than half a pound a week. Just keep in mind this approach can become less effective as you get more experienced. On the other end, for those who are less interested in losing fat and want to maximize muscle growth, use the bulking and “gaintaining” guidelines I presented earlier.
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