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With millions of people now taking GLP-1 agonists like Ozempic and Wegovy, I was curious to learn if there are known genetic mutations that predispose people to have serious side effects from these medications. So exploring the pharmacogenomic aspects of Ozempic and Wegovy. To answer these questions Dr. Josiah Allen is joining the show. Josiah Allen, PharmD, has spent over 15 years in the field of pharmacogenomics, beginning at the Mayo Clinic where he helped develop the GeneSight test. As a founding employee and the first medical science liaison at Assurex Health, he helped GeneSight become one of the fastest growing molecular diagnostic tests in history. He later served as director of medical affairs at OneOme and now works at St. Elizabeth Healthcare in Edgewood, KY, as a precision medicine pharmacist and PGY2 Clinical Pharmacogenomics pharmacy residency program director. He earned his bachelor's degree in psychology from Wheaton College and his Doctor of Pharmacy degree from the University of Minnesota. Topics Covered: The basics of pharmacogenomics and its role in personalized medicine. How genetic mutations, like those in the RET gene, influence medication risks. The pharmacogenomics of GLP-1 agonists (like Ozempic and Wegovy), including their contraindications for patients with RET mutations. Insights into the overlap between ACMG secondary findings and pharmacogenomic implications. Case studies illustrating the real-world impact of pharmacogenomics. Key Takeaways: GLP-1 agonists, such as Ozempic and Wegovy, carry a black box warning due to an association with thyroid cancer, particularly in individuals with RET gene mutations. Over one-third of the ACMG secondary findings genes have pharmacogenomic implications, emphasizing the need for clinicians to integrate genetic insights into prescribing practices. Pharmacists and geneticists need closer collaboration to bridge the gap between clinical genomics and pharmacogenomics for safer medication use. Get ready, genetic nerds—another brand-new episode of DNA Today drops next Friday! You can always count on us to deliver fresh content every Friday. While you wait, why not dive into our library of over 300 episodes? Binge them all on Apple Podcasts, Spotify, our website, or wherever you love to listen—just search “DNA Today.” DNA Today is hosted and produced by Kira Dineen, MS, LCGC, CG(ASCP)CM . Our Video Lead is Amanda Andreoli. Our Social Media Lead is Kajal Patel. Our Outreach Intern is Liv Davidson. And our logo Graphic Designer is Ashlyn Enokian, MS, CGC. See what else we are up to on Instagram, X (Twitter), BluSky, Threads, LinkedIn, Facebook, YouTube all at DNATodayPodcast. Our website is DNAToday.com. Questions/inquiries can be sent to [email protected].
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We got raw, real, and honest in this powerful Mounjaro roundtable. Four YouTubers came together to share: Why we started Mounjaro The unexpected side effects Mental health battles and breakthroughs Confidence issues, motivation, and our goals We talked about self-abuse, bipolar, fatigue, food noise, and depression — all the things people are often too afraid to say out loud. Whether you're just starting, struggling, or feeling alone in your journey… this conversation is for you. Want to see us go live next time? Drop a comment and let us know! 00:00 – Intro & Welcome 01:30 – Why We All Started Mounjaro 07:15 – First Side Effects & Surprises 13:50 – Mental Health & Mood Changes 19:40 – Food Noise, Cravings, and Triggers 26:05 – How Our Daily Lives Have Changed 33:30 – Struggles, Setbacks, and Honesty 41:20 – Community Support & YouTube Impact 47:10 – Goals for the Future 52:45 – Would We Recommend It? 58:20 – Final Thoughts & Outro @JussyMounjaroJourney https://youtube.com/@jussymounjarojourney?si=Uba9dC6zhFG6OCOa @JosSleepandSlimDownJourney https://youtube.com/@JosSleepandSlimDownJourney?si=i1HXBK_OVHcZGZj5 @MounjaroWithAly https://youtube.com/@MounjaroWithAly?si=2V57HBZ2r3RPARU5 Watch My Whole YouTube Growth playlist here: https://youtube.com/playlist?list=PL6CDMtJgYC3Ief62ipYrh1Qdc1L0_IGu5&si=S9RHXcl30QClTF3w #MounjaroJourney #WeightLossSupport #MentalHealthMatters #BipolarDisorder #ObesityStruggles #MounjaroUK #WeightLossCommunity #BodyImage #FoodNoise #OzempicJourney #Fatigue #MounjaroSideEffects #ConfidenceBoost #WeightLossMotivation #MounjaroTransformation #SelfLoveJourney #LooseSkinReality #WeightLossSupportGroup
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Semaglutide 1 mg has been making headlines in the health and wellness community as a potential game-changer in weight loss programs. This medication, originally developed to treat type 2 diabetes, has shown promising results in helping individuals achieve sustainable weight loss. With obesity rates on the rise globally, the need for effective weight loss solutions has never been more urgent. In this article, we will explore the role of semaglutide 1 mg in weight loss programs and how it can potentially revolutionize the way we approach weight management.
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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the effects of GLP-1 in the body. GLP-1 is a hormone that is released after eating and plays a crucial role in regulating blood sugar levels and controlling appetite. By activating GLP-1 receptors, semaglutide helps increase insulin production, decrease glucagon secretion, and slow down stomach emptying, all of which contribute to lower blood sugar levels and feelings of fullness.
In addition to its effects on blood sugar regulation and appetite control, semaglutide also has an impact on the brain’s reward system. Studies have shown that semaglutide can reduce cravings for high-calorie foods and dampen the brain’s response to food cues, making it easier for individuals to make healthier food choices and stick to their weight loss goals.
Furthermore, semaglutide has been found to have a positive effect on metabolism, leading to an increase in energy expenditure and fat oxidation. This means that individuals taking semaglutide may burn more calories at rest and during physical activity, resulting in greater weight loss over time.
Potential Benefits of Semaglutide 1 mg in Weight Loss Programs
One of the main advantages of using semaglutide in weight loss programs is its ability to produce significant and sustained weight loss. Clinical trials have shown that individuals taking semaglutide 1 mg can achieve an average weight loss of around 15-20% of their initial body weight over a period of 1 year, which is much higher than what is typically seen with other weight loss medications or lifestyle interventions alone.
Moreover, semaglutide has been shown to improve various markers of metabolic health, such as blood pressure, cholesterol levels, and markers of inflammation. These improvements can reduce the risk of developing obesity-related health conditions, such as cardiovascular disease, type 2 diabetes, and fatty liver disease, making semaglutide not only an effective weight loss tool but also a valuable asset in the prevention of chronic diseases.
Another benefit of semaglutide is its convenient once-weekly dosing regimen, which can improve adherence to treatment compared to other weight loss medications that require more frequent dosing. This can be especially beneficial for individuals who struggle with medication adherence or have a busy schedule that makes it difficult to remember to take multiple doses throughout the day.
Considerations for Using Semaglutide 1 mg in Weight Loss Programs
While semaglutide has shown great promise as a weight loss medication, it is important to consider potential side effects and contraindications before starting treatment. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation, which can be bothersome for some individuals but typically improve over time as the body adjusts to the medication.
Additionally, semaglutide is not recommended for individuals with a history of pancreatitis or thyroid cancer, as it may exacerbate these conditions. It is also important for individuals taking semaglutide to be monitored regularly by a healthcare provider to ensure safe and effective use of the medication and to make any necessary adjustments to the treatment plan.
In conclusion, semaglutide 1 mg has the potential to be a valuable tool in weight loss programs for individuals struggling to lose weight through diet and exercise alone. Its unique mechanism of action, significant weight loss benefits, and improvements in metabolic health make it a promising option for those looking to achieve long-term weight loss and improve their overall health and well-being.
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