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Weight loss drugs have become an increasingly popular, but controversial, way of quickly shedding extra pounds over the past few years. Part of that controversy deals with the side effects caused by some of the more well-known medications like Ozempic and Mounjaro. According to the Obesity Medicine Association (OMA), researchers are continually analyzing the pros and cons of these drugs. Here are some side effects of the eight FDA-approved weight loss drugs: Ozempic and Wegovy Ozempic and Wegovy are the brand names of a drug known as semaglutide, a medication that, according to Harvard Health, has been prescribed for about two decades to treat Type 2 diabetes. Ozempic has become controversial over the past few years as overweight and obese patients have sought it out for weight loss, creating a shortage of the drug for those using it to control their diabetes. Wegovy is the brand name for a form of semaglutide that has since been approved for weight loss. Semaglutide, which mimics a natural hormone called GLP-1, helps regulate blood sugar while slowing down the emptying of the stomach and signaling satiety or fullness to the brain. The OMA reports that the most common complaint among patients using semaglutide is gastrointestinal issues like nausea. Other side effects include fatigue, dizziness, headache, bloating, belching and heartburn.An American Medical Association study has also found that GLP-1 agonists are associated with an increased risk of pancreatitis, bowel obstruction, and gastroparesis. While headlines have warned about an increase in suicidal ideation with semaglutide, a January 2024 study in Nature Medicine suggested “a 49% to 73% lower risk of first-time or recurring suicidal ideations” compared with other obesity medications. Mounjaro and Zepbound Mounjaro and Zepbound are drugs known as tirzepatide. Mounjaro was approved in 2017 to treat Type 2 diabetes, while Zepbound was approved in more recent years to treat obesity. Like semaglutide, tirzepatide is a GLP-1 agonist that increases a person’s feeling of fullness and helps them maintain a weight loss diet. It causes common mild symptoms like nausea, constipation, diarrhea and bloating, but the OMA reports more serious side effects like kidney problems up to and including kidney failure, gallbladder symptoms, pancreatitis and hypoglycemia. Manufacturer Eli Lilly warns, however, that Tirzepatide may cause thyroid tumors or thyroid cancer. Patients should monitor themselves for symptoms like neck swelling, hoarseness, problems swallowing and shortness of breath. Contrave Contrave is the brand name for a medication that combines two drugs, bupropion and naltrexone. Bupropion, which is marketed under the brand name Wellbutrin, is an antidepressant that is also known to reduce a person’s appetite. Naltrexone, commonly sold under the brand names Revia and Vivitrol, is a medication used to treat drug and alcohol addiction. According to Drugs.com, naltrexone works by blocking the euphoric, intoxicated feeling of alcohol and opioids. It also helps reduce the cravings for the substances. The OMA reports that patients should not be prescribed Contrave if they suffer from a seizure disorder or if they take opioids for chronic pain. The most common side effects of the drug are nausea, vomiting, constipation, diarrhea, headache, dizziness, dry mouth and insomnia. Saxenda Saxenda is a medication containing liraglutide, a drug that mimics a person’s natural hormones affecting hunger, digestion and feelings of fullness. It was approved by the FDA in 2017 to treat obesity in people 12 and older. The most common side effects of liraglutide are nausea, vomiting, constipation, diarrhea, headache, fatigue, dyspepsia, dizziness and abdominal pain. It can also cause increased heart rate, increased lipase, which is a pancreatic enzyme, and decreased kidney function. Qsymia Qsymia is a medication that combines the drugs phentermine and topiramate. According to the OMA, phentermine has been around since 1959, making it the oldest and most widely used weight loss medication. The drug, which works in the brain as an appetite suppressant, is a stimulant similar to amphetamines and can be abused. It should not be used by patients who have suffered a stroke or who have heart disease, glaucoma or hyperthyroidism. The side effects of phentermine can be serious, including fast or irregular heart rate, headache, overstimulation, high blood pressure and tremors. It can also interact with several other drugs, including MAO inhibitors, alcohol, adrenergic neuron blockers and some anesthetic agents. When phentermine is combined with topiramate, an anticonvulsant, its effect on hunger is magnified. The side effects of the two drugs combined include dizziness, abnormal sensations, altered taste, insomnia, constipation and dry mouth. Topiramate also carries a risk of birth defects, so it should not be taken during pregnancy.

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Berberine, a yellow, bioactive compound naturally found in plants has been used in traditional Chinese medicine for more than 400 year. But recently, berberine have received considerable attention, including being hype as "natures Ozempic". Besides weight loss, it's also been connected to lowering blood sugar and improving heart health.

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In this episode, Mike Fave explores the critical importance of preserving lean muscle mass during weight loss, especially when using caloric restriction or fasting. He explains how lean muscle is the body’s primary source of metabolically active tissue and why losing it can lower your metabolic rate, making it harder to maintain weight loss. Learn the science behind fat mass versus fat-free mass, the impact of aging on muscle loss, and how to set up a fat-loss diet without sacrificing muscle. Discover the importance of adequate protein intake, resistance training, and strategic tracking to optimize your weight loss journey. 🔹 Looking for Help Losing Body Fat Without Losing Muscle? ✅ Download The Nutrition Blueprint → https://mikefave.com/the-nutrition-blueprint/ ✅ Work With Me → https://mikefave.com/work-with-me/ 🔹Where to Find Me: ✅ Website: https://mikefave.com/ ✅ Twitter: https://x.com/MikeFaveScience/ ✅ Instagram: https://www.instagram.com/mikefavescience/ ✅ YouTube: https://www.youtube.com/@MikeFaveScience/videos 🔹 Timestamps: 0:00 - Introduction: The Risk of Losing Lean Muscle in Weight Loss 0:14 - Importance of Maintaining Lean Muscle Mass 0:30 - Role of Metabolically Active Tissue in Weight Loss 0:38 - Impact of Caloric Restriction on Metabolic Rate 1:17 - Fat Mass vs. Fat-Free Mass: Energy Usage Explained 2:04 - Total Daily Energy Expenditure Breakdown 2:37 - Metabolically Active Organs and Their Energy Consumption 3:40 - Importance of Maintaining Fat-Free Mass for Metabolism 4:45 - Muscle Mass and Aging: Impact on Mortality and Health 5:52 - Case Study: Muscle Mass Changes from Young to Old Age 7:13 - Consequences of Muscle and Bone Loss in Aging 8:11 - Risks of Severe Caloric Restriction 10:51 - Importance of Micronutrients in Caloric Restriction 12:09 - Protein Intake: Key to Preserving Lean Muscle Mass 12:52 - Role of Resistance Training in Preventing Muscle Loss 13:45 - Importance of Adequate Protein and Resistance Training 14:14 - Risks of Yo-Yo Dieting and Loss of Lean Muscle Mass 15:28 - Strategies for Tracking Progress and Adjusting Diet 16:52 - Triangulating Symptoms, Weight, and Lean Body Mass 17:00 - Conclusion & Call to Action: Preserve Muscle While Losing Fat Sources: https://www.mdpi.com/2072-6643/10/4/423 https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2024.1363181/full https://pmc.ncbi.nlm.nih.gov/articles/PMC9036397/#R82 https://www.ncbi.nlm.nih.gov/books/NBK591031/# 🔹 Disclaimer: This video is for informational purposes only and does not constitute medical, nursing, or healthcare advice, nor does it establish a doctor-patient relationship. The use of this information is at the user’s own risk and is not a substitute for professional medical advice, diagnosis, or treatment. Users should not delay seeking medical advice and should consult a qualified healthcare provider before making any dietary, lifestyle, or medical changes. The views expressed are for educational discussion and do not constitute medical treatment or diagnosis.

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Looking to shed those extra pounds? In this video, we break down the most effective cardio exercises for fat loss. Whether you're a beginner or experienced fitness enthusiast, discover the top cardio workouts that burn fat fast and help you reach your fitness goals. Learn about HIIT, steady-state cardio, and more — all tailored to maximize fat burning. Don’t miss out on these proven strategies for achieving sustainable weight loss. Subscribe for more fitness tips and workouts! #losingweight #fatloss