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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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Achieving Weight Gain with Calorie Calculators

While many people focus on weight loss in their fitness journeys, there is a significant population that seeks to gain weight for various reasons, including muscle building, recovery from illness, or simply to achieve a healthier body mass index (BMI). Gaining weight, particularly in a healthy and sustainable manner, requires careful consideration of the types of foods consumed and the total caloric intake. Calorie calculators can be immensely helpful in determining how many calories an individual needs to consume daily in order to achieve their weight gain goals. These calculators typically take into account factors such as age, sex, weight, height, activity level, and overall health to provide an estimate of daily caloric requirements.

It is essential to recognize that not all calories are created equal. The source of the calories—whether they come from protein, carbohydrates, or fats—plays a significant role in how the body processes and utilizes them. For those aiming to gain weight, focusing on nutrient-dense foods that provide more than just empty calories is crucial. This means opting for wholesome foods that offer vitamins, minerals, and other necessary nutrients alongside the calories. Nevertheless, to effectively plan a diet aimed at gaining weight, understanding one’s caloric needs is paramount, and this is where a calorie calculator steps in.

In this article, we will explore five of the best calorie calculators designed for weight gain. Each calculator has unique features, interfaces, and methodologies that can help individuals find the right caloric intake suited to their personal goals. Whether you are looking for simplicity, detailed analysis, or a more interactive approach, there’s a calorie calculator on this list to meet your preferences. By using these tools, individuals can take the guesswork out of their nutritional planning and embark on their weight gain journey armed with the right information. Let’s delve into these top five calorie calculators to understand their benefits and how each can aid in achieving weight gain objectives effectively.

MyFitnessPal Calorie Calculator

MyFitnessPal is one of the most widely recognized names in the realm of nutrition and fitness tracking. Offering both a website and mobile application, it features an intuitive interface that makes calorie tracking straightforward and user-friendly. Users can input their current weight, target weight, height, age, and level of physical activity to generate personalized caloric intake recommendations. What stands out about MyFitnessPal is its vast database of foods, making it easy to log meals and snacks accurately.

The calculator takes into account one’s desired rate of weight gain, allowing customization for individuals who may want to put on weight slowly or more rapidly. Users can choose their target weight and the timeframe in which they hope to reach this goal, which MyFitnessPal then uses to adjust the daily caloric intake appropriately. Furthermore, the application allows users to track their macronutrients, offering insights into how much protein, fat, and carbohydrates they are consuming. This is particularly beneficial for those looking to gain weight while ensuring a balanced diet.

Another advantage of MyFitnessPal is its community support where users can connect with others on similar journeys. This social element can provide added motivation and accountability when working towards weight gain goals. With its comprehensive features, ease of use, and supportive community, MyFitnessPal is a top choice for those seeking to utilize a calorie calculator effectively in their weight gain quest.

Eat This Much

Eat This Much distinguishes itself from other calorie calculators through its meal planning capabilities. Not only does it allow users to calculate their caloric needs based on detailed inputs of personal data, but it also generates meal plans accordingly. Users can select their weight goals and dietary preferences, and the tool will offer customized meal suggestions that fit those criteria. This feature is especially valuable for individuals who may struggle with deciding what to eat to meet their nutritional targets.

The interface of Eat This Much is visually engaging and intuitive, enabling users to easily navigate through meal plans and recipes. Users can modify their caloric range depending on how aggressively they want to gain weight, and the tool will adjust its suggestions based on this input. Additionally, it provides options for different diet types, whether users adhere to vegetarian, vegan, or keto lifestyles, thus catering to a diverse audience.

Moreover, Eat This Much also allows users to update their preferences and dietary restrictions, ensuring that the suggestions remain relevant and aligned with their goals and lifestyle. By automating the meal planning process, users save time and can focus on enjoying their meals while still reaching their weight gain targets. The combination of a calorie calculator and meal planning makes Eat This Much a powerful tool for anyone looking to increase their caloric intake effectively.

Livin’ The Crunch

Livin’ The Crunch offers a unique approach to helping users understand their caloric needs for weight gain. This platform not only calculates the daily caloric intake based on the user’s measurements but also educates users on how to balance their macronutrients effectively. With a strong emphasis on understanding the types of foods that contribute to weight gain, Livin’ The Crunch promotes a comprehensive approach to nutrition.

One of the key features of this calorie calculator is the breakdown of recommended macronutrient ratios, guiding users on how to distribute their caloric intake among proteins, fats, and carbohydrates. This educational aspect makes Livin’ The Crunch particularly useful for those who may be new to tracking their diet or are unsure how to structure their meals for optimal weight gain. Additionally, the website offers resources and articles on healthy weight gain tips, recipe ideas, and personal success stories, generating a supportive environment for users.

Users can input their data to receive personalized recommendations coupled with the educational support needed to make informed dietary choices. By focusing not just on caloric intake, but on overall nutrition and health, Livin’ The Crunch strives to empower individuals on their weight gain journey with knowledge and actionable strategies. This holistic approach makes it an excellent tool for anyone looking to gain weight without compromising their health.

Calculator.net

Calculator.net presents a straightforward and efficient calorie calculator that is easy to use and accessible. The platform allows users to input their weight, height, age, and activity level to determine their caloric needs based on their weight gain goals. The simplicity of Calculator.net appeals to individuals who may prefer a no-fuss, quick way to understand their caloric requirements without the bells and whistles found in more complex applications.

Another appealing aspect of Calculator.net is its emphasis on maintainability. Users can return to update their statistics as they progress in their weight gain journey, which helps in recalibrating their caloric needs effectively. The daily caloric goals set by Calculator.net take into account various factors, including whether the user aims to gain a moderate amount of weight or an aggressive increase, making it versatile for different approaches to weight gain.

Additionally, Calculator.net offers tips and articles on healthy weight gain, including the importance of calorie-dense foods that help users reach their goals efficiently. While it may lack the comprehensive features of more intensive meal planners, it shines in its simplicity and straightforwardness. For those who want an easy way to calculate their caloric intake without overwhelming details, Calculator.net excels and serves as a reliable tool in achieving weight gain objectives.

SparkPeople Calorie Tracker

SparkPeople offers a robust calorie tracking platform that integrates a calorie calculator alongside various fitness resources and community support. This tool allows users to set specific weight gain goals, helping them determine how many calories they should consume to achieve their target weight in a healthy manner. The added benefit of SparkPeople is its comprehensive health-oriented resources, which include articles, recipes, and workout plans.

The interface of SparkPeople is user-friendly, making it easy to log food intake and monitor progress over time. Users can customize their profiles by specifying their dietary preferences, such as low-carb or high-protein, which helps tailor the caloric recommendations even further. Moreover, SparkPeople promotes accountability through its community forums, where users can connect with others who share similar goals, making the weight gain journey feel less isolating.

In addition to calorie tracking, SparkPeople emphasizes the importance of physical activity in achieving weight gain through muscle growth. The platform includes fitness plans designed to complement dietary goals, creating a holistic approach to health. With an array of resources at their disposal, users are empowered to take control of their nutritional and physical health, making SparkPeople a strong contender among calorie calculators aimed at weight gain.

Final Thoughts and Common Queries

In conclusion, selecting the right calorie calculator is imperative for those aiming to gain weight. Each of the tools discussed—MyFitnessPal, Eat This Much, Livin’ The Crunch, Calculator.net, and SparkPeople—offers unique features that can cater to different preferences and needs. While some users may benefit more from meal planning features, others might prioritize a straightforward approach to calorie counting. Thus, identifying which tool aligns best with personal preferences is crucial in maximizing effectiveness in weight gain strategies.

Many individuals wonder about the role of macronutrients in weight gain. While it is essential to increase caloric intake, the distribution of these calories matters significantly. A healthy balance of proteins, carbohydrates, and fats can help in muscle development and overall well-being. Additionally, can one gain weight without resorting to unhealthy food choices? The answer is yes. Focusing on nutrient-dense foods such as nuts, whole grains, lean proteins, and healthy fats can promote healthy weight gain without leading to adverse health effects.

Some might also ask how long it typically takes to see results from using a calorie calculator effectively. This can vary based on individual metabolism, compliance with caloric recommendations, and personal goals. Generally, a gradual weight gain of 1-2 pounds per week is considered healthy and manageable for most people. Regularly monitoring progress and adjusting caloric needs as weight increases is essential in maintaining a successful weight gain journey.

For those embarking on this weight gain journey, utilizing a reliable calorie calculator is fundamental in establishing a structured and informed approach to nutrition. By combining these tools with a healthy diet and physical activity, individuals can work towards achieving their weight gain goals while fostering overall health and vitality. Ultimately, it is about striking the right balance of caloric surplus and nutritional quality, leading to a sustainable change in body composition.

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How To Starting The Keto Diet And Why You Should Ketodiet Keto Ketorecipes

The popularity of the ketogenic diet has skyrocketed in recent years as more and more people are seeking effective ways to lose weight and improve their overall health. One of the key components of the keto diet is limiting carbohydrate intake and increasing consumption of healthy fats. While this can be an effective way to enter a state of ketosis where the body burns fat for fuel, many people struggle to stick to a strict keto diet due to the limited food options available.

That’s where keto supplements like Keto Gummies come in. These gummies are designed to provide a convenient and delicious way to support your keto lifestyle. But with so many options on the market, it can be overwhelming to choose the right one for you. In this article, we will provide a comprehensive analysis of Keto Gummies, including real user feedback to help you make an informed decision.

Ingredients and Benefits

Keto Gummies are made with a blend of natural ingredients that are specifically chosen to support your keto diet. These ingredients may include MCT oil, collagen, and exogenous ketones, all of which are known for their ability to promote fat burning and increase energy levels. MCT oil, for example, is a type of healthy fat that is easily converted into ketones, making it an ideal source of energy for those following a keto diet. Collagen is also beneficial for supporting healthy skin, hair, and nails, which can often suffer during weight loss.

One of the key benefits of Keto Gummies is that they can help curb cravings and keep you feeling full between meals. This can be especially helpful for those who struggle with snacking or overeating while following a keto diet. By providing your body with a steady source of nutrients and energy, these gummies can help you stay on track and reach your weight loss goals more effectively.

In addition to supporting weight loss, Keto Gummies may also help improve mental clarity and focus. This is because ketones are a preferred source of fuel for the brain, and by increasing your intake of exogenous ketones through these gummies, you may experience improved cognitive function and overall mental performance. This can be especially beneficial for those who lead busy lifestyles and need to stay sharp throughout the day.

Usage and Dosage

When it comes to incorporating Keto Gummies into your daily routine, it’s important to follow the recommended dosage guidelines provided by the manufacturer. Typically, you will be instructed to take a certain number of gummies per day, either with or without food. It’s important to read the label carefully and not exceed the recommended dosage to avoid any potential side effects.

For best results, it’s recommended to take Keto Gummies consistently as part of a balanced diet and exercise routine. While these gummies can be a helpful supplement to your keto lifestyle, they are not a magic solution for weight loss. It’s important to focus on creating healthy habits and staying consistent in order to see lasting results. Incorporating these gummies into your routine can be a helpful tool, but they should not be relied upon as the sole method for achieving your weight loss goals.

In terms of taste and texture, Keto Gummies are typically formulated to be delicious and easy to chew. This can make them a convenient option for those who struggle with swallowing pills or have a sensitive stomach. However, it’s important to note that individual preferences may vary, so it’s a good idea to try a small sample before committing to a larger supply.

Real User Feedback

One of the best ways to determine the effectiveness of a product is to hear from real users who have tried it themselves. When it comes to Keto Gummies, many people have reported positive experiences with this supplement. Users have noted that they experienced increased energy levels, reduced cravings, and improved mental clarity after incorporating these gummies into their daily routine.

Some users have also mentioned that they found it easier to stick to their keto diet while taking these gummies, as they provided a tasty and convenient option for staying on track. Others have mentioned that they noticed a difference in their weight loss progress and overall well-being after using Keto Gummies regularly. Overall, the feedback on this product has been largely positive, with many users reporting noticeable benefits from adding these gummies to their diet.

As with any supplement, it’s important to remember that individual results may vary, and what works for one person may not work for another. It’s always a good idea to speak with your healthcare provider before starting any new supplement regimen, especially if you have any underlying health conditions or are taking medications. By doing your research and listening to your body, you can determine whether Keto Gummies are the right choice for you and your keto lifestyle.

Summary and FAQ

In summary, Keto Gummies can be a helpful addition to your keto diet by providing a convenient and delicious way to support your weight loss goals. Made with natural ingredients like MCT oil, collagen, and exogenous ketones, these gummies are designed to promote fat burning, increase energy levels, and improve mental clarity. By following the recommended dosage guidelines and incorporating these gummies into a balanced diet and exercise routine, you may experience positive results in your weight loss journey.

If you’re considering trying Keto Gummies, you may have some questions about how to incorporate them into your routine and what to expect in terms of results. Here are some frequently asked questions to help guide you in making an informed decision:

1. How long does it take to see results from Keto Gummies?

Results may vary depending on individual factors such as diet, exercise, and overall health. Some users may notice a difference in energy levels and cravings within a few days, while others may take longer to see physical changes.

2. Are there any potential side effects of taking Keto Gummies?

While Keto Gummies are generally considered safe for most people, some individuals may experience minor side effects such as stomach discomfort or bloating. It’s important to consult with your healthcare provider before starting any new supplement to ensure it’s right for you.

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3. Can I take Keto Gummies if I’m not following a keto diet?

While Keto Gummies are designed to support a keto lifestyle, they can still benefit those who are not following a strict keto diet. The natural ingredients in these gummies can help support weight loss and increase energy levels, regardless of your current dietary habits.

By considering these questions and doing your research, you can determine whether Keto Gummies are the right choice for you and your health goals. Remember to listen to your body and stay consistent in your routine to maximize the benefits of this supplement.

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Why Choose Kickin’ Keto Com?

As the website Kickin’ Keto Com says, the ketogenic lifestyle is not about ketogenic diet recipes Kickin’ Keto Com is a succinct and informative website that is replete with resources to help you on your keto journey – from meal plans, recipes, shopping and cooking tips and articles, this website supports you, step by step as you journey towards a keto diet that suits you. It is aimed at personalising the keto journey, so you feel empowered, learn and gain the tools needed to make healthy choices and succeed with the keto diet.

However, the most attractive and valuable feature of Kickin’ Keto Com are custom meal plans you can create based off of your dietary restrictions and nutritional needs. Are you a carnivore? A vegetarian? Do you have certain food allergies? Kickin’ Keto Com has a meal plan for you. The possibilities are endless with Kickin’ Keto Com. Never again stress about planning your meals!

Besides meal-planning, the site (Kickin’ Keto Com) also includes expert advice; before-and-after accounts; daily challenges and forums where you can exchange advice and gluten-free recipes with other site members for further support. Kickin’ Keto Com provides you with a lot of information so you can make informed choices and remain motivated.

The Kickin’ Keto Com Community

We all need support when it comes to lifestyle changes, however big or small, which is why we try to provide as much as possible. We have a high-energy support community with a forum, Facebook group, and email list so you can support each other, be held accountable, and cheer each other up along the way. Even if you just need a place to high five or hug someone through their hard keto days, the Kickin’ Keto Com community has your back.

As well as the site, Kickin’ Keto Com hosts monthly events and challenges, as well as regularly awarding prizes – everything from cooking and wellness workshops by phone to online fitness challenges, recipe contests, and much more. With a community at your fingertips, you’ll be hit, continually, with the ‘expansion’ push. Things will keep coming up that will inspire you to do more, think bigger, and feel more – to go further in the keto lifestyle than you ever thought possible.

Transform Your Life with Kickin’ Keto Com

Still on the ketogenic fence? Unsure if Keto is really for you? Find out today … visit Kickin’ Keto Com! Join like-minded individuals; engage with supportive practitioners; shop for ketogenic resources at Kickin’ Keto Com! It’s your uber online starting gate to a low-carb, high-fat, ketogenic life! A keto lifestyle offers a great alternative to the status quo. With the internet at your fingertips, you’ll find friends, algorithms and apps ready to lead you down the path to better blood glucose, better health, and better living overall. And Kickin’ Keto Com has all the resources you need: articles, blogs, videos and podcasts to help you track your progress. But don’t go it alone. Arrange for close follow-up with your doctor, as well as with a registered dietitian nutritionist, who will monitor your health and supplement questions with answers or referrals. If that sounds overwhelming, consider seeking the help of a company that provides low-carb medical and nutritional support, but beware of the algorithms and programs that lead to consistencies in metabolic health.

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