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Drs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt
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In this video, people who have lost weight after taking weight loss drugs (such as Wegovy, Mounjaro, Zepbound, etc.) share who is on their care team, and how they found healthcare professionals they could trust and rely on. You can read about Pete’s weight loss to qualify for bariatric surgery, Larisa’s struggle with food noise, and Arelis’s experience taking semaglutide after weight-loss surgery here. Pete's Weight Loss Story: https://goodrx.co/PeteWeightLoss Larisa's Weight Loss Story: https://goodrx.co/LarisaWeightLoss Arelis' Weight Loss Story: https://goodrx.co/ArelisWeightLoss Go to https://goodrx.co/health for the answers you need from doctors, pharmacists, and journalists you can trust. Follow Us On Social: TikTok - https://goodrx.co/TikTok Instagram - https://goodrx.co/instagram Facebook - https://goodrx.co/Facebook Twitter - https://goodrx.co/Twitter #weightloss #weightlossmedication #semaglutide
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Shark Tank is a popular television show where entrepreneurs pitch their business ideas to a panel of potential investors, or “sharks.” In a recent episode, one entrepreneur brought a new product to the table – keto diet pills. These pills claim to help people achieve ketosis, a state where the body burns fat for fuel instead of carbohydrates, leading to weight loss. The sharks were intrigued by the idea of a weight loss product, but had questions about the effectiveness and safety of the pills.
Product Presentation
The entrepreneur behind the keto diet pills presented their product to the sharks, explaining how the pills were formulated to help people reach ketosis faster and more efficiently. They touted the benefits of the keto diet, including weight loss, increased energy, and improved mental clarity. The sharks were interested in learning more about the ingredients used in the pills and the scientific research supporting their claims.
One of the sharks questioned the entrepreneur about the potential side effects of the keto diet pills, expressing concern about the safety of promoting a product that alters the body’s natural metabolic process. The entrepreneur assured the sharks that the pills were made with all-natural ingredients and had been tested for safety and efficacy. They also shared testimonials from satisfied customers who had experienced positive results while taking the pills.
Investment Discussion
As the sharks deliberated on whether or not to invest in the keto diet pills, they debated the potential market for such a product. Some sharks expressed skepticism about the effectiveness of the pills, citing the lack of long-term studies on the ketogenic diet and its impact on weight loss. Others saw the potential for a lucrative business opportunity in the growing trend of ketogenic diets and weight loss supplements.
After much discussion, one of the sharks made an offer to invest in the keto diet pills, but with certain conditions attached. They proposed a partnership agreement that would involve further testing and development of the product, as well as marketing and distribution strategies to reach a wider audience. The entrepreneur accepted the offer, and a deal was struck on the show.
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Following the episode of Shark Tank featuring the keto diet pills, the entrepreneur and the shark who invested in the product worked together to refine the formula and launch a marketing campaign. The pills gained popularity among consumers looking to lose weight and improve their health through the ketogenic diet. Sales of the product soared, leading to a successful partnership between the entrepreneur and the shark investor.
Overall, the episode featuring the keto diet pills on Shark Tank was a success story of entrepreneurship and collaboration. The product’s journey from pitch to investment to market success showcased the potential of innovative ideas in the health and wellness industry. As the demand for ketogenic diet products continues to grow, the keto diet pills found a place in the market and helped many people achieve their weight loss goals.
FAQ
1. Are keto diet pills safe to take?
While keto diet pills may be made with natural ingredients, it’s important to consult with a healthcare professional before starting any new dietary supplement. Individual responses to supplements can vary, so it’s best to make an informed decision based on your own health needs and goals.
2. Do keto diet pills really work for weight loss?
Some people may experience weight loss while taking keto diet pills, especially if they follow a ketogenic diet and exercise regularly. However, results can vary, and it’s essential to combine supplements with a healthy lifestyle for long-term success.
3. Can anyone take keto diet pills?
While keto diet pills may be suitable for many people, individuals with certain medical conditions or dietary restrictions should consult with a healthcare provider before taking any supplement. Pregnant or nursing women, as well as those with allergies or sensitivities to specific ingredients, should proceed with caution.
4. How do keto diet pills help with ketosis?
Keto diet pills typically contain ingredients that support the body’s transition into ketosis, such as exogenous ketones or MCT oil. These ingredients can help boost energy levels, curb cravings, and enhance fat burning, promoting a state of ketosis that can aid in weight loss and overall health benefits.
5. What should I look for in a quality keto diet pill?
When choosing a keto diet pill, look for products made with high-quality, natural ingredients that are free from fillers or additives. It’s also essential to research the manufacturer’s reputation and seek customer reviews to ensure the product is safe and effective. Additionally, consider consulting with a healthcare professional for personalized recommendations based on your health goals.
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Disclaimer: The information presented on my channel should not be considered as health, fitness, legal, or other advice. Viewers should always seek advice from a qualified professional before making any changes to their diet, exercise routine, or lifestyle.
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The Keto Diet is one of the fastest growing trends out there today and with it comes the growth in the demand for legit Keto Supplements. If you haven’t heard of LeannX till now, don’t worry you’re not late to the party. Keto Supplements are the next big thing in the world of nutrition and one new company that manages to stand out is LeannX. Offering some of the best Ketogenic Supplements on the market, every product by LeannX is designed to either take your Keto Diet to the next level or support your new style of eating. From Elevating your energy levels to suppressing your appetite or supporting your endocannabinoid system, LeannX more than has what it takes to be the go to for Keto Supplements.
Why Choose LeannX?
Quality reigns supreme when selecting your keto supplements. LeannX products are made from only the finest ingredients, sourced from scientifically proven to be effective. Every LeannX keto supplement has been uniquely formulated and is geared to keep you in ketosis and provide the energy your body needs to be functioning at its peak on a keto diet.
Quality isn’t their sole selling point. Transparency is also in LeannX’s DNA. This is why they put each of the products through third-party testing for potency and purity, so you know exactly what’s on the label is precisely what’s inside the bottle. You’ll shop with confidence – because with LeannX, there’s zero guesswork.
LeannX will support you on this path, providing top-grade products and customer service. Experts are available to consult you and provide advice on the best products for your own needs. You won’t just receive a product when you choose LeannX: you will get the efficient expert who serves you throughout your product usage.
LeannX Product Line
Whether you want to sip on some exogenous ketones to maintain nutritional ketosis, add some MCT oil to your salad before digging in, or stock up on keto-friendly snacks so your diet doesn’t slow you down, LeannX has you covered! Their products are great for newbies who want to ease their way into keto-hood, as well as keto veterans who want to maximise their results.
Another of LeannX’s flagship products are their exogenous ketones – supplements that will put you into ketosis faster and allow you to burn fat for fuel. Perhaps you are working out and need an energy boost. Perhaps you are on a cheat day and can use a hand to get right back to it. Reach for LeannX exogenous ketones – the perfect addition to any ketogenic diet toolkit.
For an extra boost, you can purchase their exogenous ketones in addition to their popular MCT oil products. MCT oil has become very popular, especially among strict dieters, because of its ability to convert to ketones quickly. Anyone undertaking a ketogenic diet can greatly benefit from taking this type of oil. LeannX produces their MCT oil with the best possible ingredients, and it comes in a variety of flavours suitable for many palettes.
FAQ
1. Is LeannX safe to use? Yes, all of the LeannX products contain natural ingredients that have been tested and proven for quality, potency and purity.
2. When can I expect to see results from LeannX products? Results may vary; however, many of our customers have reported improved energy levels, appetite control and overall feeling of well being after a few weeks of taking their LeannX products regularly.
3. If you are not following the Ketogenic Diet, yoU can uSt buY LeanniX prOducts? Whilst LeannX was formulated following the Ketogenic Diet, these products are for anyone who wants to promote healthier living.
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