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In continuation of my update "Metformin" GLP-1 receptor agonists, a class of drug used to treat type 2 diabetes, likely trump the widely prescribed metformin for curbing dementia risk in people with the condition, finds the largest study of its kind, published in the open access journal BMJ Open Diabetes Research & Care. The findings suggest that future clinical guidelines for the treatment of type 2 diabetes would do well to consider prioritizing drugs with both blood glucose and neuroprotective effects, say the researchers. Published research suggests that both GLP-1 receptor agonists and metformin, which are widely used to treat type 2 diabetes, protect the brains of people with the disease. But as yet there have been no direct real-world comparisons of the potential impact of these drugs on dementia risk—a risk that is around 70% higher in people with type 2 diabetes. To explore this further, the researchers drew on anonymized electronic health records from a global health research network (Trinetx) spanning the period 2004 to 2024 to track the development of dementia in patients with type 2 diabetes, treated with either GLP-1 receptor agonists or metformin (87,229 patients in each group; average age 58) for at least six consecutive months. There was no significant difference in vascular dementia risk between the two types of drug when used as first line therapy. But GLP-1 receptor agonist use was associated with a significantly lower cumulative (10%) risk of developing dementia, overall, with an incidence of almost 2.5% (2,130 people) compared with an incidence of nearly 5% (4,215 people) for metformin. And specifically, taking this type of drug was associated with a 12% lower risk of developing Alzheimer's disease, and a 25% lower risk of developing non-vascular dementias than metformin use. Further in-depth analyses showed that these positive effects were evident across all age groups, but with the strongest effect among the over 60s, women, and those of white ethnicity. Risk of death from any cause was also lower: nearly 5% of those treated with GLP-1 receptor agonists died compared with nearly 9% of those treated with metformin. "Both medications demonstrate neuroprotective properties, such as reducing neuroinflammation and oxidative stress, improving insulin sensitivity, and enhancing cerebrovascular health, which likely contribute to their benefits in overall dementia," explain the researchers. But unlike metformin, whose benefits primarily derive from systemic metabolic effects, GLP-1 receptor agonists exert direct central nervous system effects by crossing the blood-brain barrier, they add. "However, the multifactorial nature of [vascular dementia], driven by cerebrovascular damage, such as small vessel disease and white matter lesions, poses significant challenges for pharmacological interventions targeting metabolic or neurodegenerative pathways," they continue. This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. And the researchers point out that the tracking period, while sufficient for observing dementia outcomes, may not fully capture long-term cognitive effects, especially given the progressive nature of Alzheimer's disease. REF:https://www.med-chemist.com/2025/07/glp-1-diabetes-drugs-likely-trump.html
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“It's simple. It's painless, and it was a miracle. In three weeks I lost 18 pounds, and by three months, I had lost 38 pounds..." For several years Ozempic has been on the market to treat type 2 diabetes. It improves the way the body handles excesses of the hormone insulin. A side effect was that patients lost 15 percent of their body weight. So last year, in June of 2021, it was reformulated and approved for weight loss for patients, who are not diabetics, under the name Wegovy. “This drug is not a stimulant. It simply makes you feel full. We know that it affects your brain. It mimics a hormone that affects the satiety centers in your brain,” explained Bariatric Surgeon Dr. Matthew French. Dr. French of Surgical Specialists of Louisiana, says about 20 of the clinic's patients have used Wegovy. “And they say they just don't get hungry. They don't want the food. They don’t have the craving. And that's a powerful tool for losing weight,” explained Dr. French. “And I wasn't hungry, which was great. The best thing about this drug is it made alcohol taste horrible,” said Hare who noted she packed on part of her weight from the sugary calories in beer and wine. But after six months, Ramsey is no longer on Wegovy. Her cost-saving coupon ran out. Most Louisiana insurance companies don't pay for weight-loss medication like hers. Despite the long-term cost savings when people maintain ideal weight, companies don't include it in their coverage. The other problem is the drug is in high demand and can be difficult to get.
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