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In this episode, I sit down with Dr. Christle Guevarra—physician, strength athlete, and co-author of Bodybuilding Anatomy—to unpack the truth about GLP-1 medications like semaglutide & tirzepatide, how they impact muscle mass and metabolism, and what coaches and clients over 40 need to know. We talk about bone density, strength training differences between men and women, how to coach someone on GLP-1s responsibly, and why mindset—not just macros—makes or breaks long-term success. This one’s full of real talk, practical advice, and a lot of laughs. HOW TO FIND CHRISTLE: Instagram: https://www.instagram.com/dr.christle/ FIT40 LINKS ✅ Want to get your nutrition on track? Book a free call with me to get an individualized nutrition assessment by clicking this link: https://calendly.com/coachfitzz/assessment?month=2025-06 ✅ Do you thrive on monthly challenges and group support? Check out FIT40 Group Coaching by clicking this link: https://coach.everfit.io/package/BG758131 ✅ Need professional level 1:1 accountability to help you finally reach your goals? Check out FIT40 Coaching by clicking this link: https://fit40coaching.com/ AFFILIATE LINKS: Try Tonal for 30 Days Risk Free: https://tonal.sjv.io/FIT40 Get 10% Off The Genius Protein Shot: https://www.geniusshot.com/?ref=BRYAN_FIT40&transaction_id=10214dd14c839e450a4423af7b1f8e CONNECT WITH ME ONLINE Facebook: https://www.facebook.com/bryan.fitzsimmons Instagram: ⁠⁠⁠⁠https://www.instagram.com/coach_fitzz/⁠⁠⁠⁠ Tiktok: ⁠⁠⁠⁠⁠https://www.tiktok.com/@coach_fitzz?is_from_webapp=1&sender_device=pc Youtube: https://www.youtube.com/@bryan_fit40

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Semaglutide is a medication that has gained attention in recent years for its potential weight loss benefits. Originally developed to help individuals with type 2 diabetes manage their blood sugar levels, semaglutide has shown promising results in helping people lose weight as well. In fact, recent studies have shown that individuals who take semaglutide may experience significant weight loss compared to those who do not. This has sparked interest among both healthcare professionals and individuals looking to shed excess pounds.

How Does Semaglutide Work for Weight Loss?

Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) in the body. GLP-1 is known to regulate appetite, food intake, and body weight, making it a key player in weight management. By acting like GLP-1, semaglutide can help individuals feel fuller for longer periods, reduce cravings for high-calorie foods, and ultimately lead to weight loss. In addition to its appetite-suppressing effects, semaglutide can also boost metabolism and promote the burning of stored fat, making it an effective tool for achieving weight loss goals.

One of the primary ways semaglutide promotes weight loss is by slowing down the emptying of food from the stomach. This delay in gastric emptying can help individuals feel full and satisfied for longer periods, reducing the overall amount of food consumed. Additionally, semaglutide can improve insulin sensitivity and reduce blood sugar levels, which can further contribute to weight loss by preventing fat storage and promoting the utilization of stored fat for energy.

Studies have shown that individuals who take semaglutide for weight loss may experience a reduction in body weight, body fat percentage, and waist circumference. These results are particularly significant for individuals who are overweight or obese and struggling to lose weight through diet and exercise alone. Semaglutide can provide an added boost to weight loss efforts and help individuals achieve their desired weight goals more effectively and sustainably.

Is Semaglutide Safe for Weight Loss?

Semaglutide is generally considered safe for weight loss when used as directed by a healthcare professional. However, like any medication, semaglutide may cause side effects in some individuals. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and temporary, but individuals should consult their healthcare provider if they experience persistent or severe symptoms.

It is important to note that semaglutide is not a magic pill for weight loss and should be used in combination with a healthy diet and regular exercise for optimal results. Additionally, semaglutide may not be suitable for everyone, especially individuals with a history of pancreatitis, thyroid cancer, or certain gastrointestinal disorders. It is important to discuss any medical conditions or concerns with a healthcare provider before starting semaglutide for weight loss.

What Are the Benefits of Using Semaglutide for Weight Loss?

One of the key benefits of using semaglutide for weight loss is its effectiveness in promoting significant weight loss compared to other weight loss interventions. Studies have shown that individuals who take semaglutide may lose more weight and achieve greater improvements in metabolic health markers than those who follow traditional diet and exercise programs alone. Semaglutide can provide a powerful tool for individuals struggling to lose weight and improve their overall health.

In addition to its weight loss benefits, semaglutide has been shown to have positive effects on cardiovascular health, reducing the risk of heart disease and stroke in individuals with obesity and related health conditions. By improving insulin sensitivity, blood sugar control, and lipid profile, semaglutide can help individuals reduce their risk of developing chronic diseases and improve their overall quality of life.

Overall, semaglutide offers a promising option for individuals looking to lose weight and improve their health. With its ability to reduce appetite, promote fat burning, and enhance metabolic health, semaglutide can be a valuable tool in achieving sustainable weight loss and long-term wellness goals.

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When it comes to weight loss medication, Semaglutide and Ozempic are two popular options that many people consider. Both drugs are FDA-approved for the treatment of obesity and have shown promise in helping individuals achieve significant weight loss. However, there are differences between the two medications that may make one more suitable for certain individuals than the other. In this article, we will compare Semaglutide and Ozempic for weight loss to help you determine which medication may be better for you.

Effectiveness

Semaglutide and Ozempic belong to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists, which work by mimicking the effects of the GLP-1 hormone that regulates blood sugar levels and appetite. Both medications have been shown to be effective in promoting weight loss in clinical trials. However, studies have suggested that Semaglutide may be slightly more effective than Ozempic in terms of weight loss. A study published in the New England Journal of Medicine found that individuals taking Semaglutide lost an average of 15.3% of their body weight, compared to 9.8% for those taking Ozempic.

Additionally, Semaglutide has been shown to have a greater impact on reducing waist circumference and improving markers of cardiovascular risk compared to Ozempic. These findings suggest that Semaglutide may be a more potent weight loss medication overall.

It is important to note that individual responses to weight loss medications can vary, and what works best for one person may not be the best option for another. It may be necessary to try both medications to see which one is more effective for you personally.

Safety

Both Semaglutide and Ozempic are generally well-tolerated, with nausea being the most common side effect reported by users. However, there are some differences in the safety profiles of the two medications that may be important to consider.

One potential concern with Semaglutide is its association with an increased risk of thyroid tumors in animals. While this risk has not been definitively established in humans, it is something to be aware of when considering this medication. In contrast, Ozempic has not been associated with an increased risk of thyroid tumors, making it a potentially safer option for some individuals.

Additionally, Semaglutide is administered via a once-weekly injection, while Ozempic is given as a once-weekly injection. Some individuals may prefer the convenience of a once-weekly injection, while others may find the daily injections of Semaglutide to be more manageable.

Cost

Cost can be a significant factor when considering weight loss medications, as these drugs can be quite expensive. Currently, both Semaglutide and Ozempic are brand-name medications that may not be covered by insurance. However, there are some ways to reduce the cost of these medications.

Some insurance plans may cover part or all of the cost of Semaglutide or Ozempic, so it is important to check with your insurance provider before starting treatment. Additionally, both medications offer savings programs and copay cards that can help reduce out-of-pocket expenses. Consider discussing these options with your healthcare provider to determine the most cost-effective choice for you.

Ultimately, the decision between Semaglutide and Ozempic for weight loss will depend on individual factors such as effectiveness, safety, and cost. It is important to consult with your healthcare provider to determine which medication may be the best choice for you based on your specific needs and health history.

Conclusion

In conclusion, both Semaglutide and Ozempic are effective weight loss medications that have shown promise in helping individuals achieve significant weight loss. Semaglutide may be slightly more effective than Ozempic in promoting weight loss, but individual responses to these medications can vary. Safety concerns and cost considerations should also be taken into account when deciding between the two medications. Ultimately, the best choice for you will depend on your specific needs and health history, so be sure to consult with your healthcare provider to determine the most suitable option.

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