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The 2 minute update looks at a randomized trial comparing tirzepatide and semaglutide for weight loss. Which one helps patients lose more weight? We don’t see studies like this one often – pharmaceutical companies rarely fund head-to-head trials with competitors’ medications. But the manufacturer of tirzepatide sponsored this study. It’s a randomized open-label trial that included 751 adults, 65% of whom were women. Mean age was about 45, and mean BMI was 39.4. They excluded anyone with diabetes. They were randomized to weekly subcutaneous tirzepatide or semaglutide. The dose was titrated up to the maximum dose, or less depending on side effects. Treatment was for 72 weeks. The primary outcome was total percentage weight loss. Those on tirzepatide lost an average of 20.2% of their starting weight, while those on semaglutide lost 13.7% of their weight. They also evaluated what portion of patients lost a certain percentage of weight, such as 15% or 20%, and more patients on tirzepatide were in every one of those categories. Of course, GLP-1 agonists come with adverse events. Overall, about 78% of patients experienced an adverse event, and the rates were similar in both groups. But only 6.1% of the tirzepatide group and 8.0% of the semaglutide group stopped due to adverse events. Weight loss from semaglutide changed obesity treatment dramatically in recent years, and now the results with tirzepatide are even better. Unfortunately, cost is a big barrier, and it does not appear that prices will come down anytime soon. Reference: Aronne et al. Tirzepatide as compared with semaglutide for the treatment of obesity. NEJM 2025 May 11; Online ahead of print If you would like more updates like this, subscribe to our channel above, or sign up for our email newsletter at https://cmevacations.com/ For more information on future Hospital Medicine or Outpatient Medicine CME conferences, head to www.CMEvacations.com utm_source=YouTube&utm_medium=link&utm_campaign=2min.

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Today, we're diving into the transformative effects of GLP-1 agonist drugs, specifically focusing on semaglutide, in the realm of weight loss and type 2 diabetes management. We'll explore firsthand accounts of patients experiencing remarkable transformations in their lives thanks to these incredible medications. GLP-1 agonists like semaglutide have been making waves in the medical community for their dual benefits in managing type 2 diabetes and promoting weight loss. From shedding excess pounds to improving overall well-being, the impact of these drugs is nothing short of extraordinary. In this video, we'll dive into the real-life stories of individuals who have witnessed significant weight loss and newfound confidence through the use of semaglutide. From TikTok success stories to personal testimonials, prepare to be inspired by the incredible journeys of those who have embraced these medications as a catalyst for change. #semaglutide #ozempicweightloss #ozempic #semaglutideweightloss #wegovy #wegovyweightloss

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🌟 Welcome to Downsized Live with Laraine and Christopher Durham! 🌟 Join us as we dive into the transformative world of GLP-1 weight loss! As a couple who have experienced the incredible benefits of these medications firsthand, we’re thrilled to share our journey, practical tips, and tricks with you and build a community together. In this interactive session, we’ll answer all your burning questions about weight management with GLP-1 agonists like Mounjaro, Zepbound, Ozempic, Wegovy, Tirzepatide, and Semaglutide. Don’t miss out – bring your questions and join us on this path to better health! 🌟 DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-st... DOWNSIZED WEBSITE: https://thedownsized.org/ Start your weight loss journey today! We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8.

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