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Learn more at Penn Medical Group: https://pennmedicalgroup.com/ or call us at (610) 321-7777 for a free consultation. Semaglutide is a medication initially approved for the treatment of type 2 diabetes. However, its weight-loss properties have gained significant attention, and it's now also approved for weight management in certain patients. Let's compare semaglutide to some other weight loss medications: Semaglutide (Wegovy, Ozempic) Mechanism of Action: It is a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the function of GLP-1. This leads to reduced appetite and slowed gastric emptying, among other effects. Efficacy: Some studies have shown significant weight loss with semaglutide. One study showed a mean weight loss of around 15% of initial body weight in those taking semaglutide for weight management. Side Effects: Nausea, vomiting, diarrhea, constipation, abdominal pain, and increased risk of diabetic retinopathy. Orlistat (Alli, Xenical) Mechanism of Action: Works in the gut to inhibit the action of lipases, which are enzymes that break down fats. As a result, it reduces the absorption of dietary fats. Efficacy: Moderate weight loss, typically around 5-10% of initial body weight. Side Effects: Gastrointestinal issues like oily stools, flatulence, and frequent bowel movements. It may also reduce the absorption of fat-soluble vitamins. Phentermine-Topiramate (Qsymia) Mechanism of Action: Combines two drugs. Phentermine suppresses appetite and topiramate (originally an antiepileptic drug) appears to work on several pathways related to appetite, satiety, and energy expenditure. Efficacy: Studies have shown average weight loss of about 8-10% of initial body weight. Side Effects: Increased heart rate, birth defects if taken during pregnancy, tingling in the hands and feet, insomnia, and dry mouth. Naltrexone-Bupropion (Contrave) Mechanism of Action: Naltrexone is an opioid antagonist and bupropion is an antidepressant. Together, they work on the central nervous system to reduce appetite and increase energy expenditure. Efficacy: Studies have shown an average weight loss of about 5-9% of initial body weight. Side Effects: Nausea, constipation, headache, vomiting, dizziness, insomnia, and dry mouth. Liraglutide (Saxenda) Mechanism of Action: Another GLP-1 receptor agonist, similar to semaglutide. Efficacy: Studies have shown a weight loss of about 5-9% of initial body weight. Side Effects: Nausea, diarrhea, constipation, abdominal pain, and increased risk of pancreatic disease. Benzphetamine (Didrex), Phendimetrazine, and Diethylpropion: Mechanism of Action: Sympathomimetic appetite suppressants. Efficacy: Modest weight loss. Side Effects: Increased blood pressure, palpitations, dry mouth, and insomnia. When considering any weight loss medication, the benefits should always be weighed against potential risks, and it's essential to discuss with a healthcare provider. Weight loss medications are typically used in combination with diet, exercise, and behavior modification for best results. Also, it's essential to note that not all patients will respond to medications in the same way, and individual results can vary.

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Losing fat can be achieved through a combination of regular exercise, a healthy diet, and lifestyle changes. Here are some tips that may help: Exercise regularly: Regular exercise can help you burn calories and reduce body fat. Aim for at least 150 minutes of moderate-intensity aerobic exercise or 75 minutes of vigorous-intensity aerobic exercise per week. Incorporate strength training exercises to build lean muscle mass, which can increase your metabolism. Eat a healthy and balanced diet: Focus on a diet that is rich in whole foods, such as fruits, vegetables, whole grains, lean protein, and healthy fats. Avoid processed and high-calorie foods, sugary drinks, and excessive alcohol. Eat in moderation and pay attention to portion sizes. Stay hydrated: Drinking plenty of water can help you feel full and reduce your calorie intake. Aim to drink at least 8 cups of water per day. Get enough sleep: Lack of sleep can lead to weight gain, as it disrupts your hormone balance and metabolism. Aim for 7-9 hours of sleep per night. Manage stress: Chronic stress can lead to weight gain, as it increases the production of cortisol, a hormone that promotes fat storage. Find ways to manage stress, such as practicing mindfulness, meditation, or yoga. Remember that losing fat takes time and patience. It is important to make sustainable lifestyle changes and avoid crash diets or extreme measures that may harm your health. Consult with a healthcare professional before making any major changes to your diet or exercise routine

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You’re showing up, putting in the effort… so where are the results? Let’s break down a few things that might be holding you back 👇 💧 Hydration Matters – Not drinking enough water? That alone can lead to water retention and make fat loss harder to see. Aim for 2.5–3.5L per day to stay sharp and support your goals. 😴 Prioritise Your Sleep – Your body does most of its recovery (and fat burning!) while you sleep. Late-night scrolling and caffeine overload could be getting in the way. Try winding down earlier and getting 7–9 hours. 🥗 Watch Your Nutrition – Even if you’re training hard, if you're eating in a calorie surplus, fat loss won't happen. Build your meals around whole foods, veggies, and smart portions. 🏋️‍♀️ Challenge Your Body – Doing the same workout over and over? Your body adapts! Try adding more weight, changing tempo, or switching up the intensity to keep progressing. 👉 If this hit home, give it a like, save it for later, and don’t be afraid to ask for help.