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Jacobs Solutions CEO Bob Pragada joins 'Squawk Box' to discuss the building opportunities of life science facilities to meet the growing demand for GLP-1s.

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A class of medications known as GLP-1 receptor agonists has revolutionized the treatment of type 2 diabetes and obesity. These drugs mimic the action of glucagon-like peptide-1 (GLP-1), a hormone that stimulates insulin secretion and inhibits glucagon release, helping to regulate blood sugar levels and promote weight loss. In this podcast, we’ll talk about the differences among some of the most well-known GLP-1 receptor agonists for type 2 diabetes. Ozempic (Semaglutide) Form: Injectable Dosing Frequency: Once weekly Uses: Primarily for type 2 diabetes (lower blood sugar and A1c); also approved for reducing the risk of major cardiovascular events like heart attack and stroke in adults with type 2 diabetes and known heart disease. Keep in mind, Wegovy (semaglutide) is a higher-dose version that’s approved for weight loss. When you start taking Wegovy or Ozempic, you’ll begin with a low dosage. Your prescriber will increase your dosage every four weeks until you reach the target amount. However, the specific dosage you inject will differ depending on the medication. The maximum dose for Ozempic is 2mg weekly, while the target dose for Wegovy is 2.4mg weekly. Rybelsus (Semaglutide) Form: Oral tablet Dosing Frequency: Once daily Uses: Lower blood sugar and A1c in people with type 2 diabetes. Rybelsus shares the same active ingredient as the injectable medications Ozempic and Wegovy. Ozempic is also approved for Type 2 diabetes, while Wegovy is approved specifically for weight loss. Rybelsus is available in three different strengths: 3 mg, 7 mg, and 14 mg. Similar to Ozempic, the dose is slowly increased every 4 weeks. Good to know: It's important to take Rybelsus first thing in the morning with 4 oz of water. After taking it, you should wait at least 30 minutes before eating, drinking, or taking other medications. Failing to do so may reduce its effectiveness. Currently, Rybelsus is undergoing clinical trials to evaluate its effectiveness for weight loss. The trials involve higher doses than those approved for diabetes treatment. Results indicate that a 50 mg dose of oral semaglutide (Rybelsus) achieves weight loss comparable to Wegovy. Trulicity (Dulaglutide) Form: Injectable Dosing Frequency: Once weekly Uses: Type 2 diabetes; and like Ozempic, it’s also approved for reducing the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Like Ozempic and Rybelsus, you will start at a low dose to help reduce side effects. Your healthcare provider will then gradually increase the dose, balancing the management of side effects with the benefits of blood sugar control. The maximum dose for Trulicity is 4.5mg weekly. Victoza (Liraglutide) Form: Injectable Dosing Frequency: Once daily Uses: Type 2 diabetes; also approved to reduce the risk of major cardiovascular events in adults with type 2 diabetes and established cardiovascular disease. Victoza is one of three GLP-1 agonists approved for treating Type 2 diabetes in children aged 10 and older. The other options are Trulicity (dulaglutide) and Bydureon BCise (exenatide). More on this later. Ozempic, however, is only approved for use in adults. Saxenda and Victoza are both injectable medications containing liraglutide, but they are approved for different uses. Saxenda is FDA-approved for chronic weight management in people 12 and older, while Victoza is approved for treating Type 2 diabetes in people 10 and older. Victoza also helps lower the risk of major adverse cardiovascular events in adults with diabetes and heart disease. Both medications are injected once a day, starting with a low dose that is gradually increased over time. The target dose for Saxenda is 3 mg once daily, whereas the maximum dose for Victoza is 1.8 mg once daily. Byetta (Exenatide) Form: Injectable Dosing Frequency: Twice daily Uses: Type 2 diabetes. Additional Benefits: It has a shorter duration of action than other GLP-1 agonists, which may be preferable for some patients. Byetta, approved in 2005, was the first GLP-1 medication of its kind for diabetes. Its active ingredient, exenatide, is a synthetic version of a substance found in Gila monster saliva. The recommended starting dose for Byetta is 5 mcg twice daily, administered within 60 minutes before your morning and evening meals. After one month, your healthcare provider may increase the dose to 10 mcg twice daily. Starting at a lower dose helps reduce stomach-related side effects. Bydureon BCise (Exenatide Extended-Release) Form: Injectable Dosing Frequency: Once weekly Uses: Type 2 diabetes. Additional Benefits: Extended-release formulation provides a more convenient dosing schedule compared to Byetta. Unlike Byetta, Bydureon BCise has a fixed dose of 2 mg administered once weekly, on the...
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The ketogenic diet has gained immense popularity in recent years for its ability to help individuals shed excess weight, improve cognitive function, and boost overall health. As the demand for keto-friendly products continues to rise, entrepreneurs have been quick to capitalize on this trend by pitching their innovative keto products on the hit TV show Shark Tank. In 2021, the show featured an array of groundbreaking keto products that have the potential to revolutionize the way we approach the keto diet. From delicious snacks to convenient meal kits, these top keto innovations are sure to make sticking to the keto lifestyle easier and more enjoyable than ever before.
Delicious Keto Snacks
One of the standout keto products featured on Shark Tank in 2021 was a line of delicious keto snacks that are perfect for satisfying those midday cravings without derailing your diet. These snacks are not only low in carbs and sugar but also high in healthy fats, making them the ideal choice for anyone following a ketogenic lifestyle. With a variety of flavors to choose from, these keto snacks are a tasty and convenient way to stay on track with your diet goals.
Another keto snack that caught the attention of the sharks was a revolutionary protein bar that is not only keto-friendly but also vegan and gluten-free. Packed with plant-based protein and fiber, this bar is the perfect on-the-go snack for anyone looking to maintain their keto diet while enjoying a delicious treat. With no artificial ingredients or added sugars, this protein bar is a guilt-free indulgence that will keep you satisfied between meals.
For those with a sweet tooth, a keto-friendly dessert option showcased on Shark Tank in 2021 is sure to hit the spot. This decadent treat is low in carbs and sugar but high in flavor, making it the perfect guilt-free dessert for anyone following a ketogenic diet. Whether you’re craving chocolate, caramel, or a fruity flavor, this keto-friendly dessert is a delicious way to satisfy your cravings without compromising your diet.
Convenient Keto Meal Kits
In addition to keto snacks, Shark Tank also featured a range of convenient keto meal kits that are designed to make meal prep a breeze for busy individuals. These meal kits come with all the ingredients you need to create delicious and nutritious keto meals in the comfort of your own home, saving you time and effort in the kitchen. With easy-to-follow recipes and pre-portioned ingredients, these meal kits take the guesswork out of meal planning and make sticking to your keto diet easier than ever.
Another innovative keto meal kit featured on the show is designed specifically for individuals following a strict ketogenic diet. This meal kit includes a variety of keto-friendly meals and snacks that are low in carbs and sugar but high in flavor and nutrients. Whether you’re looking to lose weight, improve your energy levels, or simply enjoy delicious keto meals, this meal kit has everything you need to succeed on your keto journey.
For those looking to add more variety to their keto diet, a customizable meal kit showcased on Shark Tank in 2021 is the perfect solution. This meal kit allows you to choose from a variety of keto-friendly ingredients and recipes to create a meal plan that suits your tastes and preferences. With the option to swap out ingredients, adjust portion sizes, and mix and match recipes, this customizable meal kit makes it easy to stay on track with your keto diet while enjoying a diverse and satisfying array of meals.
Revolutionary Keto Supplements
While diet and exercise are crucial components of a successful keto lifestyle, supplements can also play a key role in supporting your health and wellness goals. In 2021, Shark Tank showcased a range of innovative keto supplements that are designed to enhance the effects of the ketogenic diet and help you achieve your desired results. From MCT oil to exogenous ketones, these supplements can help boost your energy levels, improve your workout performance, and increase your fat-burning potential.
One standout keto supplement featured on the show is a powerful blend of natural ingredients that are scientifically proven to support ketosis and promote fat loss. This supplement is formulated to help your body enter into a state of ketosis more quickly and easily, making it easier for you to burn fat and shed excess weight. With no artificial fillers or additives, this keto supplement is a safe and effective way to enhance your ketogenic diet and achieve your health and fitness goals.
For those looking to improve their mental clarity and focus on a keto diet, a brain-boosting supplement showcased on Shark Tank in 2021 is a game-changer. This supplement is formulated with powerful nootropics and adaptogens that are known for their ability to enhance cognitive function, reduce stress, and improve mood. Whether you’re looking to boost your productivity at work, enhance your workouts, or simply feel sharper and more alert, this brain-boosting supplement is a must-have for anyone following a ketogenic lifestyle.
In summary, the keto innovations featured on Shark Tank in 2021 are set to revolutionize the way we approach the ketogenic diet. From delicious snacks to convenient meal kits to revolutionary supplements, these top keto products are designed to make sticking to the keto lifestyle easier and more enjoyable than ever before. Whether you’re looking to lose weight, improve your health, or simply enjoy delicious keto-friendly foods, these innovative products have something for everyone. With the continued popularity of the ketogenic diet, we can expect to see even more groundbreaking keto products featured on Shark Tank in the years to come.
FAQ:
Q: Are keto products safe to use?
A: Yes, keto products are generally safe to use, especially when they contain natural and high-quality ingredients. However, as with any dietary supplement, it is essential to consult with a healthcare professional before incorporating new products into your diet, especially if you have any underlying health conditions or are taking medications.
Q: Can keto products help with weight loss?
A: Yes, keto products can be a useful tool for supporting weight loss when used in conjunction with a healthy diet and regular exercise. Keto-friendly snacks, meal kits, and supplements can help you stay on track with your ketogenic diet and achieve your weight loss goals more effectively.
Q: How do I know which keto products are right for me?
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A: When choosing keto products, it’s essential to consider your dietary preferences, health goals, and any specific dietary restrictions you may have. It’s also a good idea to read reviews, do your research, and consult with a healthcare professional or nutritionist if you’re unsure about which products will best support your keto lifestyle.
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