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Weight loss drugs have become an increasingly popular, but controversial, way of quickly shedding extra pounds over the past few years. Part of that controversy deals with the side effects caused by some of the more well-known medications like Ozempic and Mounjaro. According to the Obesity Medicine Association (OMA), researchers are continually analyzing the pros and cons of these drugs. Here are some side effects of the eight FDA-approved weight loss drugs: Ozempic and Wegovy Ozempic and Wegovy are the brand names of a drug known as semaglutide, a medication that, according to Harvard Health, has been prescribed for about two decades to treat Type 2 diabetes. Ozempic has become controversial over the past few years as overweight and obese patients have sought it out for weight loss, creating a shortage of the drug for those using it to control their diabetes. Wegovy is the brand name for a form of semaglutide that has since been approved for weight loss. Semaglutide, which mimics a natural hormone called GLP-1, helps regulate blood sugar while slowing down the emptying of the stomach and signaling satiety or fullness to the brain. The OMA reports that the most common complaint among patients using semaglutide is gastrointestinal issues like nausea. Other side effects include fatigue, dizziness, headache, bloating, belching and heartburn.An American Medical Association study has also found that GLP-1 agonists are associated with an increased risk of pancreatitis, bowel obstruction, and gastroparesis. While headlines have warned about an increase in suicidal ideation with semaglutide, a January 2024 study in Nature Medicine suggested “a 49% to 73% lower risk of first-time or recurring suicidal ideations” compared with other obesity medications. Mounjaro and Zepbound Mounjaro and Zepbound are drugs known as tirzepatide. Mounjaro was approved in 2017 to treat Type 2 diabetes, while Zepbound was approved in more recent years to treat obesity. Like semaglutide, tirzepatide is a GLP-1 agonist that increases a person’s feeling of fullness and helps them maintain a weight loss diet. It causes common mild symptoms like nausea, constipation, diarrhea and bloating, but the OMA reports more serious side effects like kidney problems up to and including kidney failure, gallbladder symptoms, pancreatitis and hypoglycemia. Manufacturer Eli Lilly warns, however, that Tirzepatide may cause thyroid tumors or thyroid cancer. Patients should monitor themselves for symptoms like neck swelling, hoarseness, problems swallowing and shortness of breath. Contrave Contrave is the brand name for a medication that combines two drugs, bupropion and naltrexone. Bupropion, which is marketed under the brand name Wellbutrin, is an antidepressant that is also known to reduce a person’s appetite. Naltrexone, commonly sold under the brand names Revia and Vivitrol, is a medication used to treat drug and alcohol addiction. According to Drugs.com, naltrexone works by blocking the euphoric, intoxicated feeling of alcohol and opioids. It also helps reduce the cravings for the substances. The OMA reports that patients should not be prescribed Contrave if they suffer from a seizure disorder or if they take opioids for chronic pain. The most common side effects of the drug are nausea, vomiting, constipation, diarrhea, headache, dizziness, dry mouth and insomnia. Saxenda Saxenda is a medication containing liraglutide, a drug that mimics a person’s natural hormones affecting hunger, digestion and feelings of fullness. It was approved by the FDA in 2017 to treat obesity in people 12 and older. The most common side effects of liraglutide are nausea, vomiting, constipation, diarrhea, headache, fatigue, dyspepsia, dizziness and abdominal pain. It can also cause increased heart rate, increased lipase, which is a pancreatic enzyme, and decreased kidney function. Qsymia Qsymia is a medication that combines the drugs phentermine and topiramate. According to the OMA, phentermine has been around since 1959, making it the oldest and most widely used weight loss medication. The drug, which works in the brain as an appetite suppressant, is a stimulant similar to amphetamines and can be abused. It should not be used by patients who have suffered a stroke or who have heart disease, glaucoma or hyperthyroidism. The side effects of phentermine can be serious, including fast or irregular heart rate, headache, overstimulation, high blood pressure and tremors. It can also interact with several other drugs, including MAO inhibitors, alcohol, adrenergic neuron blockers and some anesthetic agents. When phentermine is combined with topiramate, an anticonvulsant, its effect on hunger is magnified. The side effects of the two drugs combined include dizziness, abnormal sensations, altered taste, insomnia, constipation and dry mouth. Topiramate also carries a risk of birth defects, so it should not be taken during pregnancy.

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Stigma and judgment don't allow those people in the public eye any relief from society's perception of plus-size individuals. Heather Gay shared her experience about her co-stars passing judgement on her size and wearing designer clothing. GLP-1 medications are changing the paradigm around weight loss. Ozempic, Wegovy, Mounjaro, Zepbound, Byetta, Bydureon, Victoza, Saxenda, Trulicity, and more in research are being done on these types of drugs. These drugs are typically for type 2 diabetes treatments. Still, the weight loss that has occurred has prompted the pharmaceutical industry to further develop these medications to help individuals who are obese or morbidly obese. Typically, insurance companies require a certain BMI for these drugs to be covered. Not only have these drugs shown to help with weight loss, but they are also helping with the brain's appetite centers, so they decrease cravings and increase satisfaction from meals. They slow down how fast the food leaves the stomach and create a full sensation for extended periods. These drugs help regulate blood sugar and increase energy, potentially increasing a person's metabolic rate. Now, we are seeing the emotional component of many people who have struggled all their lives with weight, deepening the understanding that weight and losing weight is a complex issue. These medications are never a simple fix and must be used with a complete lifestyle approach. Insurance companies sometimes discontinue access if you do not lose a certain percentage over time. MC is sharing her journey using Mounjaro, which she has been using since August, and she has had a 40lb weight loss. If you or someone you know is considering using one of these medications, please speak to your doctor. Beware of using imitations or medications provided by a compound pharmacy. DISCLAIMER. All of the ideas and information shared on my channel are not supported by my employer or endorsed by any company. Nor do I have any affiliates with any of the referrals listed below. Everything on my channel is shared for education and entertainment. Please speak to your doctor. The information here is not intended to replace your medical care nor to be intended for your health care. These are my experiences and what has worked or doesn't work. RESOURCES: https://www.cnn.com/2024/03/18/entertainment/oprah-winfrey-weight-loss-special/index.html https://www.womenshealthmag.com/weight-loss/a60023604/heather-gay-weight-loss/ http://main.diabetes.org/dforg/pdfs/2019/2019-cg-medications.pdf

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Use Code THOMAS for 35% off your first order of Sundays: http://sundaysfordogs.com/THOMAS Walking for Fat Loss This video does contain a paid partnership with a brand that helps to support this channel. It is because of brands like this that we are able to provide the content that we do for free. Click HERE to Subscribe: https://www.youtube.com/c/ThomasDeLauerOfficial?sub_confirmation=1 Please check out the new Shorts channel, DeLauer Clips and Workouts, here: https://www.youtube.com/channel/UCQPQImPsw74KhO0Zy2-leyA/videos Please Subscribe to my Email Newsletter Here: https://www.thomasdelauer.com/life-optimization-tactics/ Follow More of My Daily Life on Instagram: http://www.Instagram.com/ThomasDeLauer References https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241903/ https://www.nature.com/articles/s41366-018-0215-x Timestamps ⏱ 0:00 - Intro - Walking for Fat Loss 0:50 - Use Code THOMAS for 35% off your first order of Sundays! 1:31 - The Effects of Walking on Fat Loss & Inflammation 2:07 - When to Time Your Walks for Maximum Benefit