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Are you curious how GLP-1 and GIP hormones actually help you lose weight? In this video, Dr. Daniel Obi-Ofodile, MD provides the breaks down, the science behind these powerful incretin hormones for this conversation —and how they work together to reduce appetite, slow gastric emptying, and improve insulin response. Whether you’re exploring natural supplements, new medications, or just want to understand the biology behind weight loss, this explainer covers the essentials in a simple and engaging way. What you’ll learn: • What GLP-1 and GIP are • How they regulate hunger and metabolism • How they’re used in weight loss medications • Natural ways to support GLP-1 and GIP Resources: Download the free GLP-1 & GIP natural recipe at the bottom of this description. Link for the Natural products in this recipe. Arginine/citruline https://amzn.to/4j88BNc Astragulus https://amzn.to/3XAmyLz Forskohli https://amzn.to/3XzrZu4 Inulin/mountfit https://amzn.to/3Yalcar Turmeric https://amzn.to/4l3m0aS Liposomal Berberine https://amzn.to/4hS32RV Guarana https://amzn.to/4i9ijhv Alpha Lipoic acid https://amzn.to/4l72iuU Green Tea extract https://amzn.to/3FJQhLS MCT Oil https://amzn.to/4l72g6m Resveratrol https://amzn.to/3Y6ETQi Natural GLP-1 & GIP Support Formula – Liquid & Extract Forms Designed for ease of absorption and patient-friendly compliance Key Liquid/Extract-Based Ingredients & Benefits: • Berberine Extract (liquid tincture, 500 mg/day): Supports GLP-1 secretion and insulin sensitivity. • Curcumin Phytosome or Liquid Liposomal Curcumin (500–1000 mg/day): Improves absorption, supports GLP-1 modulation. • Inulin Syrup (prebiotic fiber, 5–10 g/day): Fermentable fiber increasing GLP-1 and gut microbiome health. • Forskolin Extract (Coleus forskohlii liquid, 250 mg/day): Stimulates GLP-1 secretion via cAMP activation. • EGCG from Green Tea Extract (liquid form, 300–400 mg/day): Enhances GLP-1 response, antioxidant support. • Alpha-Lipoic Acid (liquid R-ALA, 300–600 mg/day): Improves insulin action and glucose metabolism. • Hydrolyzed Whey Protein (liquid or ready-to-drink, 10–30 g/day): Increases both GLP-1 and GIP post-meal. • MCT Oil (liquid C8/C10, 5–10 mL/day): Stimulates GLP-1 and GIP via lipid-triggered gut hormone release. • Mangiferin/Resveratrol (liquid extract blend): Natural DPP-4 inhibitors that preserve incretin hormones. Suggested Use: Take extracts in divided doses with meals. Shake well and use as directed under practitioner guidance. Product Description: A liquid and extract-based formula to support natural GLP-1 and GIP function, enhance metabolic control, and promote healthy insulin response through bioavailable, easy-to-absorb plant and protein nutrients. References: 1. Nilsson M, et al. Am J Clin Nutr. 2004. (Whey protein and incretin release) 2. Steinert RE, et al. Am J Clin Nutr. 2011. (MCTs and gut hormone secretion) 3. Huang TH, et al. Phytomedicine. 2012. (Mangiferin as natural DPP-4 inhibitor) 4. Tolhurst G, et al. Diabetes. 2012. (SCFAs and incretin secretion) 5. Anand P, et al. Mol Pharm. 2007. (Bioavailability of curcumin formulations)

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Let’s talk about something I get asked a lot—should you take semaglutide (like Ozempic or Wegovy) if you’re planning to have weight loss surgery? Short answer: No. Here’s why: Weight loss surgery—whether it’s gastric sleeve or bypass—alters your anatomy and motility. It’s already an incredibly effective method for reaching and maintaining a healthy weight. Adding semaglutide on top of that can actually be harmful. Both semaglutide and surgery affect how your stomach and intestines move. Combining them can impair nutrient absorption, increase the risk of deficiencies, and lead to complications.

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As the obesity epidemic continues to rise globally, the search for effective weight loss treatments has become more crucial than ever. Semaglutide, a medication originally used to treat type 2 diabetes, has recently gained attention for its potential to aid in weight loss. But the question remains: is Semaglutide safe for weight loss?

The Safety Profile of Semaglutide

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs work by mimicking the action of a hormone called GLP-1, which helps regulate blood sugar levels and appetite. In addition to its diabetes-lowering effects, studies have shown that Semaglutide can also lead to significant weight loss in individuals who are overweight or obese.

One of the main concerns with any weight loss medication is its safety profile. Like all medications, Semaglutide comes with potential side effects that need to be considered. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and temporary, but in some cases, they can be more severe.

In rare cases, Semaglutide has been associated with more serious side effects such as pancreatitis and thyroid tumors. However, the overall risk of these side effects is low, and they are more likely to occur in individuals with a history of pancreatitis or thyroid issues. It is essential to discuss these risks with a healthcare provider before starting treatment with Semaglutide.

Who Should Consider Semaglutide for Weight Loss?

Semaglutide is not a one-size-fits-all solution for weight loss. It is typically recommended for individuals who have a body mass index (BMI) of 30 or higher or a BMI of 27 or higher with at least one weight-related health condition, such as high blood pressure or type 2 diabetes. Before prescribing Semaglutide, healthcare providers will assess the potential benefits and risks for each individual patient.

Individuals considering Semaglutide for weight loss should also be committed to making lifestyle changes, such as adopting a healthy diet and increasing physical activity. While Semaglutide can aid in weight loss, it is not a magic pill, and long-term success is more likely when combined with lifestyle modifications.

In conclusion, Semaglutide shows promise as a safe and effective option for weight loss in individuals who are overweight or obese. However, like any medication, it is essential to weigh the potential benefits against the risks and to discuss these factors with a healthcare provider. With the right support and guidance, Semaglutide may be a valuable tool in the fight against obesity.

Frequently Asked Questions About Semaglutide for Weight Loss

1. How does Semaglutide work for weight loss?

Semaglutide works by acting on receptors in the brain that control hunger and food intake. By mimicking the action of GLP-1, Semaglutide can help reduce appetite and promote feelings of fullness, leading to decreased food consumption and, ultimately, weight loss.

2. Is Semaglutide safe for long-term use?

The safety of Semaglutide for long-term use is still being studied. While some studies have shown promising results in terms of weight loss and weight maintenance, more research is needed to determine the long-term effects of Semaglutide on overall health and well-being.

3. What are the potential side effects of Semaglutide?

Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and temporary. In rare cases, Semaglutide can also lead to more serious side effects such as pancreatitis and thyroid tumors.