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GLP-1 agonists, primarily used for the treatment of diabetes, obesity, and heart disease, have become a topic of national conversation. But how do these drugs, now commonly used for weight loss, actually work and what are the implications of their long-term use? Our public webinar, “New Weight Loss Drugs (GLP-1s) Explained: Science, Impact, Potential,” held on November 21, 2024, convened leading experts to discuss the benefits and challenges of GLP-1s, issues around access, impact on weight bias, and more. This event was part of “A Healthy Exchange,” the National Academies' quarterly webinar series designed to make timely health and medicine topics accessible to everyone—patients, families, health care professionals, students, journalists, and individuals eager to learn from top experts. Find out more: https://www.nationalacademies.org/our-work/a-healthy-exchange Expert Panelists: * Dr. Jamy Ard – Vice Dean of Clinical Research, Wake Forest University School of Medicine; Co-Director, Advocate Health Wake Forest Baptist Weight Management Center * Dr. Ania M. Jastreboff – Associate Professor, Yale School of Medicine; Director, Yale Obesity Research Center * Patty Nece, J.D. – Past Chair, National Board of Directors, Obesity Action Coalition (OAC); Chair, OAC Weight Bias Committee * Dr. Donna Ryan – Professor Emerita, Pennington Biomedical Research Center Watch the full webinar to explore how these groundbreaking medications are reshaping healthcare and society.

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When it comes to weight loss medications, Semaglutide and Ozempic are two popular options that have gained attention for their effectiveness. Both medications belong to a class of drugs known as GLP-1 receptor agonists, which work by mimicking the effects of the naturally occurring hormone GLP-1 to help regulate blood sugar levels and promote weight loss. While Semaglutide and Ozempic have similar mechanisms of action, there are some key differences between the two drugs that are worth noting. In this article, we will explore the differences between Semaglutide and Ozempic for weight loss, and help you understand which medication may be the right choice for you.

Semaglutide: The New Kid on the Block

Semaglutide is a relatively new medication compared to Ozempic, having been approved by the FDA in 2017. It is available in both injectable and oral forms, with the injectable form being marketed under the brand name Wegovy for weight management. Semaglutide has been shown to be highly effective in helping individuals lose weight, with clinical trials demonstrating significant reductions in body weight compared to a placebo. The medication works by slowing down digestion, reducing appetite, and increasing feelings of fullness, which can help individuals consume fewer calories and lose weight.

One of the key advantages of Semaglutide is its convenience and ease of use. The injectable form only needs to be administered once a week, while the oral form can be taken daily with or without food. This makes it a convenient option for individuals who may have difficulty remembering to take medications regularly.

However, Semaglutide is not without its drawbacks. Some common side effects of the medication include nausea, diarrhea, and constipation, which can be bothersome for some individuals. Additionally, Semaglutide may not be suitable for individuals with a history of pancreatitis or thyroid tumors, as the medication can increase the risk of these conditions.

Ozempic: A Trusted Option for Weight Loss

Ozempic has been on the market longer than Semaglutide, receiving FDA approval in 2017. Like Semaglutide, Ozempic is also available in injectable form and works by mimicking the effects of GLP-1 to help regulate blood sugar levels and promote weight loss. Clinical trials have shown that Ozempic is effective in helping individuals lose weight, with many patients experiencing significant reductions in body weight compared to a placebo.

One of the advantages of Ozempic is its proven track record and long history of use in the treatment of diabetes and weight management. The medication has been extensively studied in clinical trials and has been shown to be safe and effective for long-term use. Additionally, Ozempic has a lower risk of hypoglycemia compared to some other weight loss medications, making it a safer option for individuals with diabetes.No Weight Loss On Semaglutide Troubleshooting Tips

However, Ozempic also has its share of side effects, including nausea, vomiting, and diarrhea. These side effects can be mild to moderate in severity and typically improve over time as the body adjusts to the medication. Like Semaglutide, Ozempic may not be suitable for individuals with a history of pancreatitis or thyroid tumors.





Choosing the Right Medication for You

When deciding between Semaglutide and Ozempic for weight loss, it is important to consider your individual needs and preferences. Both medications have been shown to be effective in helping individuals lose weight, but they may differ in terms of convenience, side effects, and other factors. Your healthcare provider can help you make an informed decision based on your medical history, weight loss goals, and lifestyle.

If you are looking for a convenient option that only needs to be administered once a week, Semaglutide may be the right choice for you. On the other hand, if you prefer a medication with a proven track record and long history of use, Ozempic may be a better fit. Ultimately, the decision between Semaglutide and Ozempic will depend on your individual needs and preferences, so be sure to consult with your healthcare provider before starting any weight loss medication.

Regardless of which medication you choose, it is important to remember that weight loss medications are just one part of a comprehensive weight loss plan. Incorporating healthy eating habits, regular physical activity, and other lifestyle changes are essential for long-term success in achieving and maintaining a healthy weight.

Overall, Semaglutide and Ozempic are two effective options for weight loss that can help individuals achieve their weight loss goals. By understanding the differences between the two medications, you can make an informed decision about which medication may be the right choice for you. Consult with your healthcare provider to determine the best course of action for your weight loss journey.

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