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In this Metabolic Classroom lecture, Dr. Bikman explores GLP-1 receptor agonists (such as Ozempic and Mounjaro) and how to use them more effectively. Ben first explains how GLP-1 is naturally produced in the gut and helps regulate glucagon suppression, slows gastric emptying, and promotes satiety. However, he highlights research showing that individuals with obesity have a blunted GLP-1 response to carbohydrates, which may contribute to overeating. He suggests that GLP-1 drugs could be used more strategically—not just for general weight loss, but specifically to control carbohydrate cravings. While these drugs can promote rapid weight loss, they can also come with serious trade-offs, including mental health risks (depression, anxiety, and suicidal thoughts), lean mass loss (up to 40% of weight lost), diminishing effects over time, and digestive complications such as gastroparesis (stomach paralysis). He critiques the current high-dose, long-term approach to these medications, arguing that most people are not using them strategically and eventually regain lost weight—primarily as fat. Dr. Bikman proposes a better approach to using GLP-1 drugs that focuses on low-dose, short-term usage to help control carbohydrate cravings, rather than suppressing appetite completely. His four-step plan includes: (1) starting at the lowest effective dose, (2) engaging in resistance training to preserve muscle mass, (3) adopting a low-carb, high-protein diet, and (4) cycling off the drug after 3-6 months to assess whether cravings remain under control. He also discusses newer GLP-1/GIP dual agonists like Tirzepatide, which may be even more effective but still require careful usage. In closing, Ben emphasizes that GLP-1 drugs should be a tool, not a crutch. The ultimate goal should be to regain control over eating habits, build long-term dietary discipline, and use the drug only when needed. He encourages those considering these medications to work closely with their healthcare providers and approach them with a long-term metabolic health strategy in mind. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #GLP1 #WeightLoss #Ozempic #Mounjaro #Wegovy #GLP1Agonist #MetabolicHealth #FatLoss #InsulinResistance #AppetiteControl #Type2Diabetes #BloodSugarControl #Tirzepatide #ObesityTreatment #HealthyLiving #LowCarbDiet #DrBenBikman #KetogenicDiet #MuscleHealth #MetabolicFlexibility Timestamps (approximate): 00:00 - Introduction: Are We Using GLP-1 Drugs the Right Way? 01:04 - What is GLP-1 & How Does It Work? 02:16 - GLP-1’s Role in Appetite & Blood Sugar Control 05:21 - Obesity & the Blunted GLP-1 Response to Carbohydrates 06:26 - The Problem with Current High-Dose GLP-1 Use 07:40 - Mental Health Risks: Depression, Anxiety, & Suicidal Thoughts 09:54 - Muscle Loss & The Risk of Frailty on GLP-1 Drugs 11:06 - Why GLP-1 Effects Fade Over Time (Diminishing Returns) 12:07 - Digestive Risks: GLP-1 Drugs & Gastroparesis 13:16 - A Smarter Way to Use GLP-1 Drugs: Targeting Carb Cravings 14:21 - Step 1: Use the Lowest Effective Dose 15:29 - Step 2: Preserve Muscle with Resistance Training 16:37 - Step 3: Low-Carb, Protein-Focused Diet 17:47 - Step 4: Cycle Off GLP-1 After 3-6 Months 18:57 - Tirzepatide: GLP-1 & GIP Dual Agonist Overview 20:02 - Final Thoughts: Using GLP-1 Medications Wisely Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: BEN10) Ben’s favorite dress shirts and pants: https://toughapparel.com/?ref=40 (use BEN10 for 10% off) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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Weight loss can be a challenging journey for many individuals. From strict diets to rigorous exercise routines, finding a sustainable solution to shedding those extra pounds can often feel like an uphill battle. One emerging option that has gained popularity in recent years is the use of semaglutide, a medication traditionally used to treat type 2 diabetes. This drug has shown promising results in promoting weight loss, sparking interest among those looking to slim down. However, determining the right dose of semaglutide for weight loss can be a complex process that requires careful consideration and guidance from healthcare professionals.

The Science Behind Semaglutide for Weight Loss

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of a hormone produced in the gut. This hormone helps regulate blood sugar levels and appetite, leading to reduced food intake and weight loss. When used in higher doses than those typically prescribed for diabetes management, semaglutide has been found to significantly impact weight loss in individuals with obesity.





Research studies have shown that semaglutide can lead to greater weight loss compared to other weight loss medications or lifestyle interventions. In fact, clinical trials have demonstrated that individuals using semaglutide experienced an average weight loss of around 15-20% of their initial body weight over the course of a year. These results have sparked excitement within the medical community and among patients struggling with obesity.

Despite its effectiveness, semaglutide is not a magic solution for weight loss. It is essential to combine medication with healthy lifestyle habits such as balanced nutrition and regular physical activity to achieve sustainable results. Additionally, the right dosage of semaglutide varies from person to person and should be determined based on individual factors such as weight, medical history, and response to the medication.

Factors to Consider When Determining the Right Dose

When it comes to finding the right dose of semaglutide for weight loss, several factors come into play. Healthcare providers will consider the individual’s baseline weight, any existing medical conditions, and previous experiences with weight loss medications. In general, the standard starting dose of semaglutide for weight loss is 0.25 mg once weekly, with the option to increase the dosage incrementally based on the individual’s progress and tolerance.

It is crucial for patients to communicate openly with their healthcare providers about their experiences with the medication, including any side effects or challenges they may encounter. Adjustments to the dose may be necessary to optimize the benefits of semaglutide while minimizing any adverse effects. Close monitoring by a healthcare professional is essential to ensure that the medication is used safely and effectively for weight loss.

In addition to the dose of semaglutide, other lifestyle factors play a significant role in achieving successful weight loss outcomes. Engaging in regular physical activity, consuming a balanced diet rich in nutrients, and prioritizing adequate sleep and stress management are all essential components of a holistic approach to weight management. Semaglutide should be seen as a tool to support these efforts rather than a standalone solution.

Conclusion

Overall, semaglutide offers a promising option for individuals seeking to achieve meaningful weight loss and improve their overall health. Finding the right dose of semaglutide for weight loss requires careful consideration and collaboration with healthcare providers. By incorporating this medication into a comprehensive weight loss plan that includes healthy lifestyle habits, individuals can increase their chances of successful and sustainable weight loss. As with any medication, it is important to approach semaglutide with caution and seek guidance from qualified healthcare professionals to ensure safe and effective use.

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Weight loss can be a challenging journey for many individuals. From strict diets to rigorous exercise routines, finding a sustainable solution to shedding those extra pounds can often feel like an uphill battle. One emerging option that has gained popularity in recent years is the use of semaglutide, a medication traditionally used to treat type 2 diabetes. This drug has shown promising results in promoting weight loss, sparking interest among those looking to slim down. However, determining the right dose of semaglutide for weight loss can be a complex process that requires careful consideration and guidance from healthcare professionals.

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