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This animated video summarizes a network meta-analysis of randomized clinical trials comparing the effects of SGLT-2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors on mortality in patients with type 2 diabetes. Read the article at: https://ja.ma/2H8FpIo. Key Points: Question: How do sodium-glucose cotransporter 2 (SGLT-2) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and dipeptidyl peptidase 4 (DPP-4) inhibitors compare in reducing mortality and cardiovascular events in patients with type 2 diabetes? Findings: In this network meta-analysis that includes 236 trials with 176 310 participants, the use of SGLT-2 inhibitors or GLP-1 agonists was significantly associated with lower all-cause mortality compared with the control groups (placebo or no treatment) (hazard ratio [HR], 0.80, and HR, 0.88, respectively) and with DPP-4 inhibitors (HR, 0.78, and HR, 0.86, respectively). Meaning: In patients with type 2 diabetes, the use of SGLT-2 inhibitors or GLP-1 agonists was associated with better mortality outcomes than DPP-4 inhibitors.
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Semaglutide, a drug originally developed to treat type 2 diabetes, has gained attention in recent years for its potential as a weight loss medication. Studies have shown that when used at higher doses, semaglutide can lead to significant weight loss in individuals with obesity. However, like any medication, there are concerns about the safety of using higher doses of semaglutide for weight loss. In this article, we will explore the maximum dose of semaglutide that is considered safe for weight loss and discuss the potential risks and benefits associated with its use.
The Maximum Dose of Semaglutide for Weight Loss
Semaglutide is currently approved by the FDA for the treatment of type 2 diabetes at a maximum dose of 1.0 mg once weekly. However, studies have shown that higher doses of semaglutide, up to 2.4 mg once daily, can lead to greater weight loss in individuals with obesity. The higher doses of semaglutide used for weight loss are not currently approved by the FDA, and the safety of long-term use at these doses is still being studied.
It is important for individuals considering using semaglutide for weight loss to consult with a healthcare provider to determine the most appropriate dosage. Healthcare providers will consider factors such as the individual’s current weight, overall health, and any existing medical conditions when determining the optimal dose of semaglutide for weight loss.
Potential Risks of High Doses of Semaglutide
While higher doses of semaglutide have been shown to be more effective for weight loss, there are potential risks associated with using the medication at these doses. Some common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects may be more severe at higher doses of the medication.
In addition to gastrointestinal side effects, there have been concerns about the potential cardiovascular risks associated with using semaglutide for weight loss. Some studies have suggested that semaglutide may increase the risk of certain cardiovascular events, such as heart attacks and strokes, especially in individuals with a history of cardiovascular disease.
Potential Benefits of Using Semaglutide for Weight Loss
Despite the potential risks, semaglutide has been shown to be an effective weight loss medication for many individuals. In addition to helping individuals lose weight, semaglutide can also improve other health markers, such as blood pressure, cholesterol levels, and blood sugar control.
Some studies have even suggested that using semaglutide for weight loss may help reduce the risk of developing type 2 diabetes in individuals who are at high risk for the disease. The medication works by mimicking the effects of a hormone called GLP-1, which helps regulate blood sugar levels and promote weight loss.
Conclusion
In conclusion, while higher doses of semaglutide may be more effective for weight loss, it is important for individuals to use the medication under the guidance of a healthcare provider to minimize the potential risks. Before starting semaglutide for weight loss, individuals should discuss the benefits and risks of the medication with their healthcare provider and work together to determine the most appropriate dosage for their specific needs.
Overall, semaglutide shows promise as a weight loss medication, but more research is needed to fully understand the long-term safety and effectiveness of using the medication at higher doses. Individuals interested in using semaglutide for weight loss should stay informed about the latest research and consult with their healthcare provider to make informed decisions about their treatment plan.
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Join Certified Nutritionist and Emmy-Winning Journalist America Arias, Culinary Director at Trifecta and Executive Chef Mario Limaduran, and Board-Certified General Surgeon Dr. William Yi in this exclusive holiday webinar, "Thriving Through the Holidays." This engaging kitchen session is tailored for those taking GLP-1 medications like Semaglutide or Tirzepatide, offering actionable tips to maintain your weight loss and health goals during the festive season: Holiday Travel Tips: Learn how to plan meals, manage medications, and navigate holiday schedules with ease. Festive Gathering Strategies: Chef Mario shares high-protein recipes, mocktail demonstrations, and portion control tips to help you enjoy the celebrations without overindulging. Post-Holiday Reset: Dr. Yi offers advice on bouncing back, managing leftovers, and staying consistent with your health goals. Whether you’re traveling, hosting, or tackling holiday challenges, this webinar equips you with the tools you need to thrive. 🎥 Featuring: America Arias: Certified Nutritionist & Emmy-Winning Journalist Chef Mario Limaduran: Culinary Director at Trifecta & Executive Chef Dr. William Yi: Board-Certified General Surgeon & Medical Consultant, OrderlyMeds
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Semaglutide is a medication that has gained popularity in recent years for its effectiveness in promoting weight loss. It is often prescribed to individuals who struggle to lose weight through diet and exercise alone. Many people have experienced significant weight loss results with semaglutide, especially in the first month of treatment. Understanding what to expect in terms of average weight loss results with semaglutide can help individuals set realistic goals and track their progress effectively.
Benefits of Semaglutide for Weight Loss
Semaglutide works by mimicking a hormone called glucagon-like peptide-1 (GLP-1) that is naturally produced in the body. This hormone helps to regulate blood sugar levels, control appetite, and promote weight loss. By using a synthetic version of GLP-1, semaglutide can help individuals feel full faster, eat less, and ultimately lose weight more effectively than through diet and exercise alone.
In clinical trials, semaglutide has been shown to help individuals lose an average of 10-15% of their body weight over a period of several months. This is a significant amount of weight loss that can lead to improvements in overall health and well-being. In the first month of treatment with semaglutide, many individuals experience rapid weight loss as their bodies adjust to the medication.
Potential Side Effects of Semaglutide
While semaglutide can be an effective tool for weight loss, it is important to be aware of potential side effects that may occur during treatment. Common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild and tend to improve over time as the body adjusts to the medication.
In rare cases, more serious side effects may occur, such as pancreatitis or kidney problems. It is important to talk to your healthcare provider about any concerns or symptoms you may experience while taking semaglutide. Your healthcare provider can help determine if the benefits of semaglutide outweigh the potential risks for your individual health.
Managing Expectations with Semaglutide
It is important to have realistic expectations when starting treatment with semaglutide for weight loss. While many people experience rapid weight loss in the first month of treatment, results may vary between individuals. Factors such as diet, exercise, genetics, and overall health can all impact how quickly and how much weight you may lose while taking semaglutide.
Some individuals may lose more weight than others in the first month of treatment, while some may experience slower progress. It is important to focus on making healthy lifestyle changes in addition to taking semaglutide to maximize weight loss results. Your healthcare provider can help create a personalized plan to support your weight loss goals while taking semaglutide.
Consulting with Your Healthcare Provider
Before starting treatment with semaglutide for weight loss, it is important to consult with your healthcare provider to determine if it is the right option for you. Your healthcare provider can evaluate your overall health, discuss your weight loss goals, and provide guidance on how to take semaglutide safely and effectively.
Your healthcare provider can also monitor your progress while taking semaglutide and make any necessary adjustments to your treatment plan. By working closely with your healthcare provider, you can ensure that you are on track to achieve your weight loss goals with semaglutide.
In conclusion, semaglutide can be an effective medication for promoting weight loss, especially in the first month of treatment. By understanding what to expect in terms of average weight loss results with semaglutide, managing expectations, and consulting with your healthcare provider, you can maximize the benefits of this medication for your weight loss goals.
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Bu bölümde Ayık Kafa podcast’in konuğu Dr. Sandra Kaufmann, MD. Bu, Dr. Kaufmann ile “yaşlanmama” planını konuştuğumuz sohbetin 2. bölümü, yani iki bölüm halinde yayınladığımız podcast’in devamı. Dr. Kaufmann, Johns Hopkins’te pediatrik anestezi alanında ihtisas yapmış, Joe DiMaggio Çocuk Hastanesi'nde Pediatrik Anestezi Şefi olarak görev yapmış ve The Kaufmann Anti-Aging Institute'i kurarak yaşlanma bilimi üzerine kapsamlı bir teori geliştiren ödüllü bir tıp doktorudur. Geçen hafta Yedi İlke’nin ilk 3’ünü ele almıştık; bugün seti tamamlıyoruz: 4. İlke Kalite Kontrolü: Hücreler bozuk DNA ve proteinleri nasıl onarır, otofajiyle çöpleri nasıl temizler? 5. İlke Bağışıklık Dengesi: Huysuz bir bağışıklık sistemi neden kronik iltihap, enfeksiyon ve kanser riskini artırır? 6. İlke Hücresel Özellikler: Beyin, kemik, deri gibi her hücre tipinin kendine özgü ömrü ve beslenme ihtiyacı vardır. 7. İlke Atık Yönetimi: Şeker kaynaklı “junk” Gelişmiş Glikasyon Son Ürünleri (AGE’ler) nasıl durdurulur? Hücreler tıkanmadan nasıl temizlenir? Kaufmann ayrıca yaygın sağlık alışkanlarının longevity üzerindeki etkilerini ve bu etkilerin nasıl azaltılabileceğini ele alıyor; mitokondrilerin enerji üretimi ve genel sağlık üzerindeki rolünü de anlatıyor. Takviye yönetiminin detaylarını da açıklayan Kaufmann, etkinlik düzeyi ve dozajın önemine de değiniyor. Sirtuinlerin hücresel sağlık ve longevity’deki kritik rolü, uyku ve sirkadiyen ritimlerin önemi ile AMP kinaz ve mTOR’un enerji düzenlemesindeki etkileşimi de konuşulan diğer başlıklar arasında yer alıyor. Ayrıca glikasyonun sağlık üzerindeki olumsuz etkileri ve vücutta etkili atık yönetiminin önemi ele alınıyor. Kaufmann, sağlığın korunmasında takviye ve ilaçların rolünü, yaşlanma mekanizmalarının anlaşılmasının gerekliliğini ve yaşam tarzı ile hedefe yönelik müdahalelerle hasarın nasıl azaltılabileceğini vurguluyor. Diyet içeceklerin etkisi, modern yaşamın toksinleriyle başa çıkma yolları, GLP-1 agonistleri kullanımı ve Kaufmann derecelendirme sistemiyle geliştirdiği özgün takviye öneri yaklaşımı da gündeme geliyor. Kaufmann, kişisel ilaç ve takviye deneyimlerini de paylaşarak sağlığa çok yönlü yaklaşımın önemini ortaya koyuyor. #EsraÇavuşoğlu #AyıkKafa #ElevatingLifeEvolvingHealth #Longevilab #DrSandraKaufmann #Longevity Dr. Sandra Kaufmann, MD: Web sitesi: https://kaufmannprotocol.com/bio Instagram: https://www.instagram.com/kaufmannlongevity/ *İş birlikleri ve Sponsorlar: https://dotshub.com/ T.C. İstanbul Gedik Üniversitesi’ne ne teşekkür ederiz. https://www.gedik.edu.tr/ *Kanalımıza üye olmak için 👉* https://www.youtube.com/@ayikkafa *Dr. Esra Çavuşoğlu, PhD* Instagram: https://www.instagram.com/esracavusoglu/ https://www.instagram.com/longevilab Web: https://www.longevilab.com/hakkimizda#esra-cavusoglu *Bize Ulaşmak İçin 👉* [email protected] *Ayık Kafa Hakkında* Dr. Esra Çavuşoğlu, PhD, kişisel tedavi deneyimlerinden başlayarak klinik psikoloji eğitimi ile devam eden çalışmalarını, yaptığı Bağımlılık odaklı doktorasını tamamlayarak bir üst aşamaya taşıdı. Ayık Kafa podcast'inde, Bağımlılık Hastalığı hakkında ilk elden bilgiler ve deneyimlerin yanı sıra son akademik çalışmalarını paylaşırken, Biohacking ve Longevity alanlarında dünyanın en yeni teknolojilerini, protokollerini, ürünlerini ve araştırmalarını ele alıyor. *Dr. Esra Çavuşoğlu, PhD Hakkında* Longevilab’in kurucusu Dr. Esra Çavuşoğlu, PhD, Amerika Birleşik Devletleri ve uluslararası düzeyde eğitimli bir klinik psikolog ve New York’ta sertifikalı bir bağımlılık terapistidir. Yale Üniversitesi Tıp Fakültesi Klinik Danışmanlık Kurulu’nda Uluslararası Gelişim Danışmanı olarak görev yapmıştır. Gaziantep Oya Bahadır Yüksel Rehabilitasyon Merkezi’nin kurucusu ve süpervizörüdür, Çavuşoğlu, Türkiye Rehabilitasyon Modeli’nin tasarımcısı ve uygulayıcısıdır. Dr. Esra Çavuşoğlu Türkiye’nin büyüyen bağımlılık sorunuyla mücadele etmek amacıyla Çağdaş Bağımlılık Çalışmaları Derneği’ni (ÇABAÇAD) kurmuştur.
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⚠️DISCLAIMER: I AM NOT A MEDICAL PHYSICIAN AND I AM NOT GIVING MEDICAL ADVICE⚠️ Hey Kuadrila! Welcome to another Vlog!! Hope you are doing great and I wish you had a lovely Christmass. I know, I know... Christmass was last week but, in my defense, festivities carry on until January 6th here in Spain, so I am still in time. LOL 🤣🎄 This is a week in my life as an actress from Bilbao (Basque Country) who is trying to make it in the industry and is going on a weight-loss journey assisted by the weight-loss medication, Mounjaro. This week I am bringing you a weight update, a full workout (actually 2), decorate for Christmass, new nails and other updates on my journey. I am still taking 5mg a week shot of the medication, which is pretty good because the progress is consistent. So there is no need to increase it yet. I may have found a nutritionist that I want to work with, but I'll have to wait until January when our first interview is scheduled. After that I'll work on bringing you more videos of what my eating looks like. I really hope you guys enjoy it! Thank you so much for watching! Please be sure to LIKE, COMMENT, SHARE and SUBSCRIBE. I would really appreciate it. Love, Amaia MY SOCIAL MEDIA: Instagram:  / a_zapirain TikTok:  / a.zapirain WHERE I GET MY MUSIC: Epidemic Sound: https://www.epidemicsound.com/music/f... Soundcloud: https://soundcloud.com/eddyjayfrompar... EQUIPMENT I USE IN THIS VIDEO: iPhone 13 Pro Max Dji Osmo Pocket 3
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Incorporating a GLP-1 probiotic into your weight loss plan can help you manage hunger, enhance fat burning, and maintain stable energy levels, all of which are crucial for successful weight management.
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